Viral and host factors related to the clinical outcome of COVID-19

Zhang, Xiaonan; Tan, Yun; Ling, Yun; Lu, Gang; Liu, Feng; Yi, Zhigang; Jia, Xiaofang; Wu, Min; Shi, Bisheng; Xu, Shuibao; Chen, Jun; Wang, Wei; Chen, Bing; Jiang, Lu; Yu, Shuting; Lu, Jing; Wang, Jinzeng; Xu, Mingzhu; Yuan, Zhenghong; Zhang, Qin; Zhang, Xinxin; Zhao, Guoping; Wang, Shengyue; Chen, Sai‐Juan; Lu, Hongzhou

doi:10.1038/s41586-020-2355-0

Cited by 848 publications

(948 citation statements)

References 27 publications

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“…This present study showed that COVID-19 patients with a history of traveling in Wuhan had some clinical characteristics and laboratory parameters that were different from COVID-19 patients who did not travel in Wuhan. Lymphocytopenia, including the reduced CD3 + , CD4 + and CD8 + T cell counts on hospital midterm were observed in Wuhan patients and percentage of severe to critical cases in WH patients was signi cantly higher than that in NWH patients, implying decrease in lymphocyte was related to the severity of the disease, which is in agreement with the statement by Zhang et al 8 . The observation that patients with COVID-19 with a history of traveling in Wuhan more prone to severe diseases could be explained from two aspects, rstly, SARS-CoV-2 might evolve adaptations to optimize its tness to novel hosts during human-to-human transmission, and viral adaptation may increase its transmissibility but attenuate its pathogenesis, similar pattern have also been observed in Ebola virus 9 .…”

Section: Discussionsupporting

confidence: 90%

First-Generation Corona Virus Disease 2019 (COVID-19) Patients with a Wuhan-Traveling History are Prone to More Severe Diseases

Zhang

Chen

Xiao

et al. 2020

Preprint

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Wuhan has the highest number of deaths and mortality from COVID-19 in China to date, but the reason remains unknown. Here we compared patients with COVID-19 with a history of traveling in Wuhan with those who did not travel in Wuhan in the early stage of pandemic with respect to a series of clinical characteristics and laboratory parameters. We observed that patients who had traveled in Wuhan had an increased rate of severe disease and longer viral duration along with fewer CD4+ and CD8+ T cells, although there was no significant difference in viral load between the two groups.

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Section: Discussionsupporting

confidence: 90%

First-Generation Corona Virus Disease 2019 (COVID-19) Patients with a Wuhan-Traveling History are Prone to More Severe Diseases

Zhang

Chen

Xiao

et al. 2020

Preprint

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“…Reports suggest that elderly COVID-19 patients are at higher risk of hospitalization, pulmonary complications, and death [25,28,34], as are elderly SARS and MERS patients [35,36]. The multiple origins of SARS-CoV-2 transmission into Thailand identi ed in the current study via phylogenetic analysis are similar to the pattern identi ed in Shanghai [29].…”

Section: Discussionsupporting

confidence: 68%

“…Upper respiratory infection, fever, coughing, sore throat, and runny nose were the most common symptoms in COVID-19 patients, as has been frequently previously reported [25][26][27][28]. Clinical outcomes may associated with host factors such as age, lymphocytopenia, and cytokine responsiveness rather than SARS-CoV-2 genetic factors [29]. As at 22 May 2020 only one of the forty patients involved in the present study had been admitted to the ICU, and all had been discharged from hospital.…”

Section: Discussionmentioning

confidence: 62%

Molecular epidemiology of the first wave of severe acute respiratory syndrome coronavirus 2 infection in Thailand in 2020

Puenpa

Suwannakarn

Chansaenroj

et al. 2020

Preprint

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The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major global concern. Several SARS-CoV-2 gene mutations have been reported. In the current study associations between SARS-CoV-2 gene variation and exposure history during the first wave of the outbreak in Thailand between January and May 2020 were investigated. Forty samples were collected at different timepoints during the outbreak, and parts of the SARS-CoV-2 genome sequence were used to assess genomic variation patterns. The phylogenetics of the 40 samples were clustered into L, G1, G2, O and T types. T types were predominant in Bangkok during the first local outbreak centred at a boxing stadium and entertainment venues in March 2020. Imported cases were infected with various types, including L, G1, G2 and O. In southern Thailand introductions of different genotypes were identified at different times. No clinical parameters were significantly associated with differences in genotype. The results indicated local transmission (type T, Spike protein (A829T)) and imported cases (types L, G1, G2 and O) during the first wave in Thailand. Genetic and epidemiological data may contribute to national policy formulation, transmission tracking and the implementation of measures to control viral spread.

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“…Additionally, aberrant leukocyte counts and composition were associated with increases in discrete in ammatory markers, speci cally C-reactive protein (CRP) and procalcitonin (PCT), while interleukin-6 (IL-6) has emerged as a biomarker for COVID-19 disease-course, with gradual but stark elevations associated with increased risk of death 8,9,10,11 . Likewise, plasma IL-6, IL-10, and IL-8 levels are high in many COVID-19 patients 10,12,13 .…”

Section: Introductionmentioning

confidence: 99%

Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

Haljasmägi

Salumets

Rumm

et al. 2020

Preprint

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SARS-CoV-2 infection risks developing into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require (ICU admission. Whereas essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12-15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNg, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.

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Viral and host factors related to the clinical outcome of COVID-19

Cited by 848 publications

References 27 publications

First-Generation Corona Virus Disease 2019 (COVID-19) Patients with a Wuhan-Traveling History are Prone to More Severe Diseases

First-Generation Corona Virus Disease 2019 (COVID-19) Patients with a Wuhan-Traveling History are Prone to More Severe Diseases

Molecular epidemiology of the first wave of severe acute respiratory syndrome coronavirus 2 infection in Thailand in 2020

Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

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