Germfree Research 1973
DOI: 10.1016/b978-0-12-340650-7.50079-9
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VIRAL ENTERIC INFECTION AND LOCAL IgA ANTIBODY: STUDIES IN GERMFREE MICE THYMECTOMIZED AND/OR INFECTED WITH A MOUSE ADENOVIRUS

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Cited by 4 publications
(3 citation statements)
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“…Adenovirus strain K87 (8)(9)(10), originally isolated and identified by Hashimoto and his colleagues from the feces of a healthy inbred mouse, strain DK1 (28), grows well in mouse kidney tissue culture (9). Either oral or parenteral administration of K87 to mice results in replication of the viral antigens exclusively in the bowel but produces no symptoms in the infected animals (19).…”
mentioning
confidence: 99%
“…Adenovirus strain K87 (8)(9)(10), originally isolated and identified by Hashimoto and his colleagues from the feces of a healthy inbred mouse, strain DK1 (28), grows well in mouse kidney tissue culture (9). Either oral or parenteral administration of K87 to mice results in replication of the viral antigens exclusively in the bowel but produces no symptoms in the infected animals (19).…”
mentioning
confidence: 99%
“…It has been reported by Hashimoto et al (2,4,11) that oral administration of mouse adenovirus strain K87 to conventional DK1 and germfree ICR mice results in viral proliferation in the intestinal tract at weeks 1 and 2 followed by the appear anceof antiviral resistance in the intestinal tract from around week 3. Challenging BALB/c nu/+ mice with adenovirus yielded very similar infection characteristics in this current experiment.…”
Section: Discussionmentioning
confidence: 98%
“…5 at 6 weeks pi, and over long-term obser vation(data not shown), no antibody was detected in either sera, intestinal wall, or intestinal content. Hashimoto et al (4) have reported that in challenging neo natallythymectomized germfree ICR mice with mouse adenovirus, longer periods of virus proliferation and cases showing delay in NT-Ab production were seen in comparison to data obtained from unoperated germfree ICR mice, as well as cases in which no NT-Ab was detected. Furthermore, there were cases from among the NT-Ab-negative mice from which no virus could be detected in feces at around 5 weeks pi.…”
Section: Discussionmentioning
confidence: 99%