Viral hepatitis and immigration: A challenge for the healthcare system

Cuenca-Gómez, José Ángel; Salas-Coronas, Joaquín; Soriano-Pérez, Manuel Jesús; Vázquez-Villegas, José; Cabezas-Fernández, M.T.

doi:10.1016/j.rceng.2016.02.002

Cited by 12 publications

(7 citation statements)

References 11 publications

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“…In contrast to southern Europe, HDV prevalence has recently begun to rise again in other European countries, such as France, Germany, Spain, and the United Kingdom, due to immigration from endemic areas (mainly from Africa, eastern Europe, and Turkey) (2,(14)(15)(16)(17)(18)(19). With on-going globalization and the influx of immigrants from less-developed endemic countries, where HBV is not controlled through vaccination and screening, regular epidemiological surveillance of HDV prevalence in Slovenia is also recommended in the near future.…”

Section: Discussionmentioning

confidence: 99%

“…As a result of vaccination against HBV, mandatory testing of blood donors, improvements in sanitation, and behavioral changes, HDV prevalence has decreased in the last 20 years in the majority of European countries, especially in southern Europe (13). However, it has recently begun rising again in some European countries, such as France, Germany, Spain, and the United Kingdom, due to immigration from endemic areas (mainly from Africa, eastern Europe, and Turkey) (2,(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review

Jelen

Hošnjak

Stunf

et al. 2016

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review

Jelen

Hošnjak

Stunf

et al. 2016

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…31 The pattern of decreasing domestic and increasing migrant HDV infections is being observed in all high-income countries. [32][33][34] In the US, HDV infection is not perceived to be of significant concern. In the 1999-2012 National Health and Nutrition Examination Survey (NHANES), 35 only 0.02% of 52,209 individuals with the HBsAg or with the anti-HBc antibody were positive for anti-HD.…”

Section: Hdv Infection In Europe and The Usmentioning

confidence: 99%

The changing context of hepatitis D

Rizzetto

Salehiniya

Negro

2021

Journal of Hepatology

115

117

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The global epidemiology of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent the end stage of the natural history of HDV, and of a younger generation of immigrants from endemic countries who account for the majority of new infections. As observed in Europe in the 1980s, the distinctive clinical characteristic of chronic hepatitis D in endemic countries is the accelerated progression to cirrhosis and hepatocellular carcinoma. Despite some recent progress, the therapeutic management of HDV remains unsatisfactory, as most patients are not cured of HDV with currently available medicines. This review article describes the current epidemiology and clinical features of chronic hepatitis D, based on the literature published in the last 10 years.

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“…5 The epidemiological landscape of chronic hepatitis D (CHD) has also changed in the last decade, with shift of the high-risk groups in high-income countries. [6][7][8] Previously, the highest risk for CHD was found among people using intravenous drugs (PWID), followed by other risk groups such as recipients of haemodialysis or multiple blood transfusions, men who have sex with men and commercial sex workers. 1,2 Concomitant of declining domestic populations of CHD, increasing dominant cases by immigrants with often younger ages have been observed.…”

Section: Introductionmentioning

confidence: 99%

“…A declining trend of HDV prevalence was reported in several countries including Italy, Spain, Turkey and Taiwan in the 1990s, owing to hepatitis B virus (HBV) vaccination as well as improvement of other protective measures 5 . The epidemiological landscape of chronic hepatitis D (CHD) has also changed in the last decade, with shift of the high‐risk groups in high‐income countries 6–8 . Previously, the highest risk for CHD was found among people using intravenous drugs (PWID), followed by other risk groups such as recipients of haemodialysis or multiple blood transfusions, men who have sex with men and commercial sex workers 1,2 .…”

Section: Introductionmentioning

confidence: 99%

Natural history of untreated HDV patients: Always a progressive disease?

Kamal

Aleman

2022

Liver International

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A severe course has been described in early studies on chronic hepatitis D (CHD), with faster pace towards liver cirrhosis with subsequent high liver‐related morbidity and mortality in the majority of patients. Earlier studies have included risk groups as people using intravenous drugs (PWID) or those with multiple co‐morbidities. During the last decade, the epidemiological landscape of CHD has changed with domestic cases decreasing while increasing cases of CHD consisting of younger persons immigrating from endemic regions to low‐endemic regions. Recently, further insights into the spectrum of the disease with an indolent disease course in a substantial proportion of persons with CHD have been gained. At diagnosis, ≥30%–50% had already established liver cirrhosis. Older age, liver cirrhosis, co‐infection with HIV and lack of interferon (IFN) therapy are the main predictors of worse clinical outcome. The newly introduced and upcoming antivirals against CHD are highly anticipated, considering the historically low virological response rates to antiviral therapy. Further knowledge is needed to fully comprehend the natural course and the spectrum of this severe form of viral hepatitis. This is also to be able to evaluate the long‐term effects of the new antivirals on disease progression.

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Viral hepatitis and immigration: A challenge for the healthcare system

Cited by 12 publications

References 11 publications

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review

Hepatitis D virus infection in Slovenian patients with chronic hepatitis B virus infection: a national prevalence study and literature review

The changing context of hepatitis D

Natural history of untreated HDV patients: Always a progressive disease?

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