Viral hepatitis and proteinuria in an area endemic for hepatitis B and C infections: another chain of link?

Huang, Jee‐Fu; Chuang, Wan‐Long; Dai, Chia‐Yen; Ho, Chi-Kung; Hwang, Shang‐Jyh; Chen, S.-C.; Wang, L.-Y.; Chang, Wen‐Yu; Yu, Ming‐Lung

doi:10.1111/j.1365-2796.2006.01686.x

Cited by 89 publications

(68 citation statements)

References 31 publications

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“…Two studies did not account for important potential confounders in their analyses (20,21). Nine studies (22)(23)(24)(25)(26)(27)(28)(29)(30) fulfilled the inclusion criteria. The complete list of articles is available on request.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Four longitudinal reports (613,368 unique patients) addressed the incidence of low eGFR in HCVinfected patients (24,25,27,28), and four cross-sectional surveys (93,919 unique patients) reported on the effect of HCV on proteinuria (22,26,29,30). The list of the 486 references is available from the authors on request.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Four cross-sectional studies provided data on the relationship between proteinuria and anti-HCV serologic status (Table 1) (22,26,29,30). Two studies defined proteinuria by standard dipstick urinalysis (26,30).…”

Section: Summary Estimates Of Outcomesmentioning

confidence: 99%

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Hepatitis C Virus Infection and Kidney Disease

Fabrizi

Martin

Dixit

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Hepatitis C virus (HCV) infection and kidney disease are both highly prevalent diseases. The association between HCV and GN has been supported by previous research but little is known about the relationship between HCV and kidney disease.Design, setting, participants, & measurements A systematic review of the published medical literature was conducted to determine if HCV is associated with increased likelihood of kidney disease in the general population. A random-effects model was used to generate a summary estimate of the relative risk for kidney disease, defined as an estimated GFR ,60 ml/min per 1.73 m 2 or proteinuria, with HCV across the published studies.Results Nine clinical studies (817,917 unique individuals) were identified. Pooling of study results demonstrated the absence of a relationship between HCV seropositive status and reduced estimated GFR (adjusted relative risk, 1.12; 95% confidence interval, 0.91, 1.38; P=0.28) according to the random-effects model. HCV seropositive serology was an independent and significant risk factor for proteinuria (defined by urine dipstick test or spot urine albumin/creatinine ratio) in the general population, with a summary estimate for adjusted relative risk of 1.47 (95% confidence interval, 1.12, 1.94; P=0.006). Significant heterogeneity was observed between studies (Ri=0.82; P value by Q test, ,0.001).Conclusions This meta-analysis shows that HCV is independently associated with proteinuria but not with reduced GFR in the general population. Substantial heterogeneity occurred.

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Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

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Hepatitis C Virus Infection and Kidney Disease

Fabrizi

Martin

Dixit

et al. 2012

Clinical Journal of the American Society of Nephrology

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“…It is possible that the use of urinary albumin-to-creatinine ratio as a screening tool, and the stratification of patients according to age, might have increased the significance of this study's results. In our group's previous large-scale surveys, patients with hepatitis C, but not those with hepatitis B, had a higher risk for CKD (27,28). According to international consensus, changes in albuminuria can be used for contemporary CKD staging and prediction of clinical outcome (29).…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with CKD in the Elderly and Nonelderly Population

Lin

Chiu

Lee³

et al. 2013

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives The risk factors for CKD in different age groups remain unknown. This communitybased study aimed to identify the risk factors for CKD in elderly and nonelderly patients.Design, setting, participants, & measurements A multistage sampling survey for CKD was conducted in 2007 in Kaohsiung County, an area with the highest prevalence of dialysis in the world. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR (eGFR) of ,60 ml/min per 1.73 m 2 . The factors for CKD in elderly and nonelderly patient groups were identified (with age 60 years as a cutoff value).Results The analyses included 3352 participants, of whom 687 had CKD. The weighted prevalence of CKD was 19.4% (95% confidence interval [CI], 18.0%-20.7%). Elderly patients typically presented with low eGFR and nonelderly patients, with proteinuria. Age, annual income, use of oral analgesics, metabolic syndrome, hyperuricemia, and hemoglobin were risk factors for CKD in both age groups. In elderly patients, risk factors were medical history of diabetes mellitus, CKD, stroke, and not using analgesic injection (odds ratios [

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“…Huang et al also conducted a prospective community-based study enrolling 10,975 subjects to compare the prevalence of proteinuria among adult population in another HBV (13.1%) and HCV (6.5%) endemic area of southern Taiwan Yu et al, 2001;Yu et al, 2001;Huang et al, 2006). Setting proteinuria as urine dipstick test ≥1+, the prevalence of proteinuria among subjects seropositive for anti-HCV was significantly higher than HBV carriers and those negative controls.…”

Section: Nephropathymentioning

confidence: 99%