Viral reactivation in the lungs of patients with severe pneumonia is associated with increased mortality, a multicenter, retrospective study

Huang, Lili; Zhang, Xuan; Pang, Lisha; Sheng, Peng; Wang, Yanqiu; Yang, Fan; Yu, Huili; Huang, Xiaohan; Zhu, Yue; Zhang, Ning; Cai, Hongliu; Tang, Liansheng; Fang, Xianyong

doi:10.1002/jmv.28337

Cited by 26 publications

(17 citation statements)

References 21 publications

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“…The patient’s peripheral blood did not reveal pathogens other than parvovirus B19 detected by metagenomic next-generation sequencing as described before ( 27 , 28 ). Also, whole exome sequencing did not identify any HLH-associated mutations.…”

Section: Case Presentationmentioning

confidence: 80%

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

et al. 2023

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Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated with intravenous immune globulin (IVIG) and the features of HLH were remission. This instance emphasizes the significance of parvovirus B19 monitoring in transplant patients with anemia; if HLH complicates the situation, IVIG may be an adequate remedy. Finally, a summary of the development in diagnosing and managing parvovirus B19 infection complicated by HLH is provided.

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Section: Case Presentationmentioning

confidence: 80%

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

et al. 2023

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“…However, results from observational studies suggest that infection with a PVL‐positive S. aureus does not predict a poor clinical outcome for pneumonia 3 . Additionally, Herpesvirus is the most common reactivated virus in the lower respiratory tract of patients with severe pneumonia, and the incidence of viral reactivation increases with a longer disease duration 4 . Therefore, testing positive for Herpesvirus is associated with viral reactivation later in the course of the disease.…”

Section: Figurementioning

confidence: 99%

A left‐sided destroyed lung in a 11‐year‐old girl: A rare sequela after Mycoplasma pneumoniae infection

Zuo,

Wang,

Zhu

2024

Pediatric Pulmonology

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Mycoplasma pneumoniae infection is one of the most common causes of community‐acquired pneumonia in children, usually experiencing a favorable prognosis.Cases of M. pneumoniae infection resulting in respiratory failure, severe pulmonary or extrapulmonary sequelae, and death are relatively rare.Currently, no cases related to a destroyed lung with Mycoplasma‐associated infection have been reported.Therefore, we report a case of a destroyed lung in an 11‐year‐old girl with Mycoplasma‐associated infection.

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“…No clear relationship has been shown between the development of HHVs reactivations and deleterious consequences regarding morbidity (prolonged mechanical ventilation, bacterial superinfection and/or hospital stay) and mortality. Therefore, there is no definitive answer to the question whether viral reactivation is only one of the hallmarks of the severity of an underlying disease or it is directly responsible for organ disease such as pneumonia [ 1 – 4 ] and colitis [ 5 ] .…”

Section: Introductionmentioning

confidence: 99%

Epstein–Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19

Mattei,

Schiavoni,

Riva

et al. 2024

ICMx

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Objectives To assess the incidences of Herpes Simplex-1 and 2 (HSV-1, HSV-2), Cytomegalovirus (CMV), Epstein–Barr Virus (EBV) reactivations in critically ill COVID-19 patients. To determine the association between viral reactivation and in-hospital mortality, Intensive Care Unit Bloodstream infection (ICU–BSI), ventilator-associated pneumonia (VAP). Design Observational retrospective cohort study. Setting COVID-19 Intensive Care Unit. Patients From November 2020 to May 2021, one hundred and twenty patients with COVID-19 severe pneumonia were enrolled and tested for HSV-1, HSV-2, CMV and EBV at the admission in ICU and weekly until discharge or death. The presence of VAP and ICU–BSI was evaluated according to clinical judgement and specific diagnostic criteria. Measurements and main results One hundred and twenty patients were enrolled. Multiple reactivations occurred in 75/120 (63%) patients, single reactivation in 27/120 patients (23%). The most reactivated Herpesvirus was EBV, found in 78/120 (65%) patients. The multivariate analysis demonstrated that viral reactivation is a strong independent risk factor for in-hospital mortality (OR = 2.46, 95% CI 1.02–5.89), ICU–BSI (OR = 2.37, 95% CI 1.06–5.29) and VAP (OR = 2.64, 95% CI 1.20–5.82). Conclusions Human Herpesviruses reactivations in critically ill patients with COVID-19 severe Pneumonia are associated with mortality and with a higher risk to develop both VAP and ICU–BSI.

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Viral reactivation in the lungs of patients with severe pneumonia is associated with increased mortality, a multicenter, retrospective study

Cited by 26 publications

References 21 publications

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

A left‐sided destroyed lung in a 11‐year‐old girl: A rare sequela after Mycoplasma pneumoniae infection

Epstein–Barr virus, Cytomegalovirus, and Herpes Simplex-1/2 reactivations in critically ill patients with COVID-19

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