Virenscarotins A–M, thirteen undescribed carotane sesquiterpenes from the fungus Trichoderma virens

Yu, Liang; Li, Dongyan; Zheng, Yuyi; Shen, Yong; Li, Qin; Wei, Mengsha; Yang, Huazhong; Ye, Saiyi; Chen, Chunmei; Zhu, Hucheng; Zhang, Yonghui

doi:10.1016/j.phytochem.2022.113368

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…A series of carotane sesquiterpenes were characterized from fermentation products of T. virens, including 13 new compounds, virenscarotins A−M (63−75). 62 Notably, virenscarotins A and B are particularly interesting, as they are the first examples of carotane sesquiterpenes formed through aldol condensation of 4-hydroxy-3-isopentenyl-benzaldehyde with two hydroxyl groups in ring A, deviating from the typical structure of carotane sesquiterpenes. The structures of these carotane sesquiterpenes 52−75 and the representative bioactive compounds are shown in Figure S3 and Figure 2, respectively.…”

Section: Cycloneranementioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Guo,

Shi,

Wang

et al. 2023

J. Agric. Food Chem.

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Trichoderma, a genus with more than 400 species, has a long history of use as an industrial bioreactor, biofertilizer, and biocontrol agent. It is considered a significant source of secondary metabolites (SMs) that possess unique structural features and a wide range of bioactivities. In recent years, numerous secondary metabolites of Trichoderma, including terpenoids, polyketides, peptides, alkaloids, and steroids, have been identified. Most of these SMs displayed antimicrobial, cytotoxic, and antifungal effects. This review focuses on the structural diversity, biological activities, and structure–activity relationships (SARs) of the SMs isolated from Trichoderma covered from 2018 to 2022. This study provides insights into the exploration and utilization of bioactive compounds from Trichoderma species in the agriculture or pharmaceutical industry.

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Section: Cycloneranementioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Guo,

Shi,

Wang

et al. 2023

J. Agric. Food Chem.

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“…In a continuation of our efforts to identify bioactive secondary metabolites from Trichoderma , 12 new polyketides and 6 known analogues were isolated from T. koningiopsis , a rhizosphere fungus obtained from the medicinal plant Polygonum paleaceum . Their planar structures were established by detailed spectroscopic analyses, and their relative and absolute configurations were determined by a combination of single-crystal X-ray diffraction, the modified Mosher’s method, chemical derivatization, the octant rule, and 13 C NMR and ECD calculations.…”

mentioning

confidence: 99%

Polyketides with Anti-Inflammatory Activity from Trichoderma koningiopsis, a Rhizosphere Fungus from the Medicinal Plant Polygonum paleaceum

Liping

Wei

et al. 2023

J. Nat. Prod.

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Twelve new fungal polyketides, koningiopisins I–P (1–8) and trichoketides C–F (9–12), together with six known congeners (13–18), were isolated from Trichoderma koningiopsis, a rhizosphere fungus obtained from the medicinal plant Polygonum paleaceum. Their structures and absolute configurations were established by spectroscopic analysis, single-crystal X-ray diffraction, the modified Mosher’s method, chemical derivatization, the octant rule, and 13C NMR and ECD calculations. Compounds 1–5 are tricyclic polyketides possessing an octahydrochromene framework with a 6,8-dioxabicyclo[3.2.1]octane core. Compounds 7 and 8 contain a unique ketone carbonyl group at C-7 and differ from other members of this group of compounds with the ketone carbonyl group at C-1. Compounds 1, 2, and 13 showed inhibitory activity on LPS-induced BV-2 cells on NO production with IC50 values of 14 ± 1, 3.0 ± 0.5, and 8.9 ± 2.7 μM, respectively.

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Virenscarotins A–M, thirteen undescribed carotane sesquiterpenes from the fungus Trichoderma virens

Cited by 2 publications

References 38 publications

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

Polyketides with Anti-Inflammatory Activity from Trichoderma koningiopsis, a Rhizosphere Fungus from the Medicinal Plant Polygonum paleaceum

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