Virological characterization of an infection with a dual-tropic, multidrug-resistant HIV-1 and further evolution on antiretroviral therapy

Masquelier, Bernard; Capdepont, Sophie; Néau, Didier; Peuchant, Olivia; Taupin, Jean‐Luc; Coakley, Eoin; Lie, Yolanda; Carpentier, Wassila; Dabis, François; Fleury, Hervé

doi:10.1097/qad.0b013e3280117053

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…There were a variety of factors which had effects on MMT retention rate [15]. The longer patients stayed in MMT clinic and no longer dependent on opioids, and receiving more supportive services, the more likely for patients to get better treatment outcome [9,16]. …”

Section: Discussionmentioning

confidence: 99%

Predictors of retention in community-based methadone maintenance treatment program in Pearl River Delta, China

Yang

Lin

et al. 2013

Harm Reduction Journal

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BackgroundThe aims were to identify predictors of treatment retention in methadone maintenance treatment (MMT) clinics in Pearl River Delta, China.MethodsRetrospective longitudinal study. Participants: 6 MMT clinics in rural and urban area were selected. Statistical analysis: Stratified random sampling was employed, and the data were analyzed using Kaplan-Meier survival curves and life table method. Protective or risk factors were explored using Cox’s proportional hazards model. Independent variables were enrolled in univariate analysis and among which significant variables were analyzed by multivariate analysis.ResultsA total of 2728 patients were enrolled. The median of the retention duration was 13.63 months, and the cumulative retention rates at 1,2,3 years were 53.0%, 35.0%, 20.0%, respectively. Multivariate Cox analysis showed: age, relationship with family, live on support from family or friends, income, considering treatment cost suitable, considering treatment open time suitable, addiction severity (daily expense for drug), communication with former drug taking peer, living in rural area, daily treatment dosage, sharing needles, re-admission and history of being arrested were predictors for MMT retention.ConclusionsMMT retention rate in Guangdong was low and treatment skills and quality should be improved. Meanwhile, participation of family and society should be encouraged.

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Section: Discussionmentioning

confidence: 99%

Predictors of retention in community-based methadone maintenance treatment program in Pearl River Delta, China

Yang

Lin

et al. 2013

Harm Reduction Journal

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“…In 2004, the Chinese government pilot tested eight MMT clinics to address the dual epidemics of HIV and drug use (Pang et al, 2007). Based on results showing a reduction in heroin use, intravenous injection, and drug-related crime, the national MMT program was scaled up rapidly.…”

Section: Introductionmentioning

confidence: 99%

Factors related to client satisfaction with methadone maintenance treatment in China

Comulada

Lin

et al. 2017

Journal of Substance Abuse Treatment

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Background This study examined clients’ treatment satisfaction with the services provided by methadone maintenance treatment (MMT) in China and explored relevant factors that are directly or indirectly associated with treatment satisfaction. Methods The study used baseline data from a randomized controlled trial conducted among 2,448 clients from 68 MMT clinics in five provinces of China. The participants reported their demographic characteristics, treatment-related factors, depressive symptoms, treatment progression, counseling rapport, and treatment satisfaction. Structural equation modeling (SEM) was used to test the direct and indirect relationships among various factors and treatment satisfaction. Results Clients’ demographic characteristics, such as older age, had both a direct effect on treatment satisfaction and an indirect effect mediated by counseling rapport. Depressive symptoms and a lack of social support had a direct negative impact on treatment satisfaction and an indirect effect mediated by treatment progression and counseling rapport. Both mediators: treatment progression (estimate=0.227, p<0.01) and counseling rapport (estimate=0.229, p<0.01), showed positive associations with treatment satisfaction. Conclusion The findings reiterate the complex nature of MMT clients’ treatment satisfaction and its interrelationship with multidimensional factors. The study has implications for evaluating the quality of care provided by MMT programs and suggests several strategies that can potentially improve MMT clients’ level of treatment satisfaction.

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“…R5 variants predominate during acute and early infection and generally persist throughout the entire course of HIV-1 infection (Berger, Murphy, and Farber, 1999). In contrast, CXCR4-using variants (dual and, to a lesser extent, X4 viruses) are detected infrequently in recent infections (Eshleman et al, 2007; Huang et al, 2009; Markowitz et al, 2005; Masquelier et al, 2007), but gradually increase in prevalence as chronic infection ensues (Berger, Murphy, and Farber, 1999; Connor et al, 1997; Melby et al, 2006; Schuitemaker et al, 1992; Wilkin et al, 2007). Generally, CXCR4-using variants are found in approximately 20% of antiretroviral (ARV) treatment-naïve individuals, characterized by higher CD4+ T-cell counts (Brumme et al, 2005; Moyle et al, 2005), and approximately 50% of highly treatment-experienced patients, characterized by low CD4+ T-cell counts (Coakley et al, 2006; Demarest et al, 2004; Hunt et al, 2006; Melby et al, 2006; Wilkin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1

Huang¹,

Frantzell²,

Toma³

et al. 2011

Virology

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To examine mutational pathways that lead to CXCR4 use of HIV-1, we analyzed the genotypic and phenotypic characteristics of envelope sequences from a large panel of patient virus populations and individual clones containing different V3 mutations. Basic amino acid substitutions at position 11 were strong determinants of CXCR4-mediated entry, but required multiple compensatory mutations to overcome associated reductions in infectivity. In contrast, basic amino acid substitutions at position 25, or substitutions at position 6–8 resulting in the loss of a potential N-linked glycosylation site, contributed to CXCR4-mediated entry, but required additional substitutions acting cooperatively to confer efficient CXCR4 use. Our assumptions, based upon examination of patient viruses, were largely confirmed by characterizing the coreceptor utilization of five distinct panels of isogenic envelope sequences containing V3 amino acid substitutions introduced by site-directed mutagenesis. These results further define the mutational pathways leading to CXCR4 use and their associated genetic barriers.

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Virological characterization of an infection with a dual-tropic, multidrug-resistant HIV-1 and further evolution on antiretroviral therapy

Cited by 13 publications

References 12 publications

Predictors of retention in community-based methadone maintenance treatment program in Pearl River Delta, China

Predictors of retention in community-based methadone maintenance treatment program in Pearl River Delta, China

Factors related to client satisfaction with methadone maintenance treatment in China

Mutational pathways and genetic barriers to CXCR4-mediated entry by human immunodeficiency virus type 1

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