Virological profile of hepatitis B infection in Black African HBsAg chronic carriers

Abstract

<span style="font-size:10.0pt;font-family:;" "=""><span style="font-size:12px;font-family:Verdana;">Aims: 1) Describe virological profile of patients fol</span><span style="font-size:12px;font-family:Verdana;">lowed-up for chronic Hepatitis B virus (HBV); 2) Search</span><span style="font-size:12px;font-family:Verdana;"> for a correlation between cirrhosis and virological profile of patients. Patients and Methods: Retrospective study about 75 HBsAg positive patients followed-up for at least one year in two medical structures of Abidjan. Studied parameters: clinical signs, biological check-up (serum transaminases every 3 months for at least one year, platelets count and prothrombin rate), abdominal echography, virological check-up (HBsAg, HBeAg, anti-HBe, total anti-HBc, anti-VHC and anti- HIV Ab, HBV DNA biannual quantification during at least one year). Histological or biochemical evaluation of hepatic activity and fibrosis were realized in case of transaminases elevation or HBV DNA > 2000 IU/ml. Results: The mean age of our 75 patients (54 men) was 42.1 ± 11.54 years. HBV was fortuitously discovered in most of our patients (74.7% of the cases). The HBV inactive chronic carriage was 50.7%; HBeAg-positive and HBeAg-negative chronic hepatitis represented respectively 9.3% and 40% of the cases. Mean B viral load was 327.5 IU/ml in HBV inactive chronic carriers, 44,047,663 IU/ml in HBeAg-positive chronic HBV and 20,231,822 IU/ml in HBeAg-negative chronic HBV. Cirrhosis prevalence was significantly high- er in positive or negative HBeAg chronic HBV than in HBV inactive chronic carriers (32.4% vs. 5.3%, p = 0.008; OR = 8.6). Conclusion: Our patients’ virological profile was dominated by HBeAg-negative chronic HBV and HBV inactive chronic carriage. The risk of having cirrhosis was multiplied by 8.6 in case of active chronic hepatitis compared with HBV inactive chronic carriage.</span></span

Treatment of Chronic Viral Hepatitis with Pegylated Interferon in Ivory Coast

“…The average age of our patients was 49.2 years. They were 42.3 years old for VHB which is consistent with other studies carried out in Côte d'Ivoire that found an average age of 42 years for chronic carriers of HBs Ag [9] and 40 [10], in France HBV patients had a median age of 44 years [11]. Our HCV patients were on average 51.9 years old, in line with SOMBIE et al who found an average age of 51 ± 6.9 years in HCV patients put on treatment [6] and a study in Morocco where HCV patients were on average 52 years old [12], in Tunisia the average age of HCV patients was 50 years [13] and 53.1 ± 8.1 years in Cameroon [7].…”

Serological Evidence of Hbc Igm Virus Among Febrile Patients in Rumueme, Port Harcourt, Rivers State, Nigeria

“…There are several different seromarkers used in the serological diagnosis of hepatitis B, and their presence or absence in a person has various clinical and epidemiological implications. Hepatitis B early antigen (HBeAg), hepatitis B surface antibody (anti-HBs), hepatitis B core antibody (anti-HBc IgG), hepatitis B envelope antibody (anti-HBe), and hepatitis B core IgM antibody (anti-HBc IgM) are all examples of HBV seromarkers (Kao, 2008;Attia et al, 2013;Aktar et al, 2021;Aniche et al, 2022). These markers may appear singly or in different combinations, depending totally on the infection's natural course (Towell & Cowie, 2012).…”