Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review

Asadi, Kamran; Gholami, Ahmad

doi:10.1016/j.ijbiomac.2021.04.005

Cited by 72 publications

(49 citation statements)

References 90 publications

(45 reference statements)

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“…Several other biomimetic strategies are emerging in nanovaccines design for combating infection and cancer. Virosome is a lipidic unilamerllar nanocarriers (60–200 nm) utilized the liposome concept but has structure similar to an enveloped virus with removed nucleocapsid 141 . Virosome is an emerging biomimetic nanoparticle for the development of nanovaccine against viral infections.…”

Section: Administration Strategiesmentioning

confidence: 99%

Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Feng

Ferdows

et al. 2022

Acta Pharmaceutica Sinica B

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Looking retrospectively at the development of humanity, vaccination is an unprecedented medical landmark that saves lives by harnessing the human immune system. During the ongoing coronavirus disease 2019 (COVID-19) pandemic, vaccination is still the most effective defense modality. The successful clinical application of the lipid nanoparticle-based Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines highlights promising future of nanotechnology in vaccine development. Compared with conventional vaccines, nanovaccines are supposed to have advantages in lymph node accumulation, antigen assembly, and antigen presentation; they also have, unique pathogen biomimicry properties because of well-organized combination of multiple immune factors. Beyond infectious diseases, vaccine nanotechnology also exhibits considerable potential for cancer treatment. The ultimate goal of cancer vaccines is to fully mobilize the potency of the immune system as a living therapeutic to recognize tumor antigens and eliminate tumor cells, and nanotechnologies have the requisite properties to realize this goal. In this review, we summarize the recent advances in vaccine nanotechnology from infectious disease prevention to cancer immunotherapy and highlight the different types of materials, mechanisms, administration methods, as well as future perspectives.

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Section: Administration Strategiesmentioning

confidence: 99%

Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Feng

Ferdows

et al. 2022

Acta Pharmaceutica Sinica B

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“…Two unique influenza envelope proteins, haemagglutinin and neuraminidase, are important for virosome reconstitution and endow virosomes with excellent adjuvant properties for the production of various vaccines [ 154 , 155 ]. Virosomes can be modified by different types of antigen epitopes and can target different kinds of host cells [ 156 ]. Virosome-based vaccine delivery systems have been successfully developed against hepatitis A viruses and influenza viruses, but in vivo applications are limited due to their high immunogenicity [ 129 ].…”

Section: Pathogen-based Npsmentioning

confidence: 99%

Bioinspired and Biomimetic Nanomedicines for Targeted Cancer Therapy

Jin

2022

Pharmaceutics

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Undesirable side effects and multidrug resistance are the major obstacles in conventional chemotherapy towards cancers. Nanomedicines provide alternative strategies for tumor-targeted therapy due to their inherent properties, such as nanoscale size and tunable surface features. However, the applications of nanomedicines are hampered in vivo due to intrinsic disadvantages, such as poor abilities to cross biological barriers and unexpected off-target effects. Fortunately, biomimetic nanomedicines are emerging as promising therapeutics to maximize anti-tumor efficacy with minimal adverse effects due to their good biocompatibility and high accumulation abilities. These bioengineered agents incorporate both the physicochemical properties of diverse functional materials and the advantages of biological materials to achieve desired purposes, such as prolonged circulation time, specific targeting of tumor cells, and immune modulation. Among biological materials, mammalian cells (such as red blood cells, macrophages, monocytes, and neutrophils) and pathogens (such as viruses, bacteria, and fungi) are the functional components most often used to confer synthetic nanoparticles with the complex functionalities necessary for effective nano-biointeractions. In this review, we focus on recent advances in the development of bioinspired and biomimetic nanomedicines (such as mammalian cell-based drug delivery systems and pathogen-based nanoparticles) for targeted cancer therapy. We also discuss the biological influences and limitations of synthetic materials on the therapeutic effects and targeted efficacies of various nanomedicines.

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“…A virosome structure like a virus is enveloped without nucleocapsid. Due to their attractive features, virosome-based vaccines have been approved in more than 45 countries (Asadi and Gholami, 2021). The virosome-based vaccine, Transvac-2 (by European MI Matric company), was developed for COVID-19.…”

Section: Virosome-based Nanovaccinesmentioning

confidence: 99%

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Debnath

Srivastava

2022

Front. Nanotechnol.

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a contagious virus that spreads exponentially across the world, resulting in serious viral pneumonia. Several companies and researchers have put their tremendous effort into developing novel vaccines or drugs for the complete eradication of COVID-19 caused by SARS-CoV-2. Bionanotechnology plays a vital role in designing functionalized biocompatible nanoparticulate systems with higher antiviral capabilities. Thus, several nanocarriers have been explored in designing and delivering drugs and vaccines. This problem can be overcome with the intervention of biomaterials or bionanoparticles. The present review describes the comparative analysis of SARS infection and its associated etiological agents. This review also highlighted some nanoparticles that have been explored in the treatment of COVID-19. However, these carriers elicit several problems once they come in contact with biological systems. Often, the body’s immune system treats these nanocarriers as foreign particles and antigens. In contrast, some bionanoparticles are highlighted here with their potential application in SARS-CoV-2. However, bionanoparticles have demonstrated some drawbacks discussed here with the possible outcomes. The scope of bioinspired nanoparticles is also discussed in detail to explore the new era of research. It is highly essential for the effective delivery of these nanoparticles to the target site. For effective management of SARS-CoV-2, different delivery patterns are also discussed here.

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Virosome-based nanovaccines; a promising bioinspiration and biomimetic approach for preventing viral diseases: A review

Cited by 72 publications

References 90 publications

Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Bioinspired and Biomimetic Nanomedicines for Targeted Cancer Therapy

Potential Application of Bionanoparticles to Treat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

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