Virtual Screening SNP-Polymorphisms of Genes Determining the High Level of General Non-Specific Reactivity of Organism

Abstract

As a result of a bioinformatic search using resources of NCBI PubMed Central, PDB, KEGG, and SNP authors have developed a database of genes associated with phenotypic manifestations of general non-specific reactivity level (GNRL). Out of 164 genes primarily relevant by search criteria for a detailed analysis there are selected 23 genes, divided into four groups: genes associated with the synthesis and reception of neurotransmitters (1); genes associated with membrane transport of electrolytes (2); genes associated with the synthesis of interleukins (3); and genes associated with certain metabolic response (4). After studying the SNP-polymorphisms annotations in the database NCBI-SNP, 10 genes and 20 SNP-polymorphisms were identified as the most likely candidates for the potential formation of phenotypic manifestations for GNRL. Further analysis of the degree of influence the conformational variability of amino acid chains in forming the secondary structure of proteins on their likely functional properties allows to select as promising the next 6 SNP: rs1851048 and rs 6777055 in the cacna2d3 gene, encoding the voltage gated Ca 2+ channels; rs2562456 in znf-ld gene of zinc-containing transcriptional regulator of DNA methylation; rs6923492 and rs362962 in grm1 gene of metabotropic glutamate receptor; and rs6314 in htr2a gene, coding for serotonin receptor type 2A.