Virtual Touch Tissue Quantification Using Acoustic Radiation Force Impulse Technology

Bai, Mingwen; Du, Lianfang; Gu, Jiying; Fan, Li; Jia, Xiaohong

doi:10.7863/jum.2012.31.2.289

Cited by 125 publications

(95 citation statements)

References 18 publications

(18 reference statements)

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“…The individual values differ in the various studies, but the differences are probably related to the number of cases examined, the size of the lesions and their histological type. To ensure adequate sensitivity and specificity a cut-off of 3.065 m/s has been proposed [48].…”

Section: Elastographic Criteriamentioning

confidence: 99%

Breast elastography: A literature review

Goddi¹,

Bonardi

Alessi

2012

Journal of Ultrasound

141

129

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KEYWORDS Sonoelastography; Breast elastography; Breast lesions.Abstract Breast elastography is a new sonographic imaging technique which provides information on breast lesions in addition to conventional ultrasonography (US) and mammography. Elastography provides a noninvasive evaluation of the stiffness of a lesion. Today, two technical solutions are available for clinical use: strain elastography and shear wave elastography. Initial evaluations of these techniques in clinical trials suggest that they may substantially improve the possibility of differentiating benign from malignant breast lesions thereby limiting recourse to biopsy and considerably reducing the number of benign breast biopsy diagnoses. This article reviews the basics of this technique, how to perform the examination, image interpretation and the results of major clinical studies. Although elastography is easy to perform, training and technical knowledge are required in order to obtain images permitting a correct interpretation. This paper will highlight the technique and point out common pitfalls.Sommario L'elastosonografia mammaria è una nuova tecnica di imaging a ultrasuoni che fornisce informazioni aggiuntive sulle lesioni della mammella rispetto all'ecografia e alla mammografia. Consente una valutazione non invasiva della rigidità tessutale di una lesione. Sono attualmente disponibili due soluzioni tecniche per uso clinico: l'elastografia con strain e l'elastografia shear wave. I primi studi clinici di valutazione di queste tecniche suggeriscono che esse possano migliorare la caratterizzazione delle lesioni mammarie differenziando quelle benigne dalle maligne e riducendo in modo sostanziale il numero di biopsie per lesioni benigne. Questo articolo rivisita le basi tecniche, i criteri interpretativi delle immagini, i principali studi clinici e le possibili cause di errore. Per quanto l'elastosonografia sia di facile esecuzione, richiede tuttavia un training e delle conoscenze tecniche adeguate per ottenere immagini correttamente interpretabili. ª

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Section: Elastographic Criteriamentioning

confidence: 99%

Breast elastography: A literature review

Goddi¹,

Bonardi

Alessi

2012

Journal of Ultrasound

141

129

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“…A weak negative correlation calculated in SWE, "X.XX" is displayed on the monitor [10,11]. There are various interpretations of "X.XX" [5,10,[12][13][14][15], with a major view being that "X.XX" represents the SWVs that exceed the range of 1−10 m/s for SWE [5,10,12]. In their study, Bojunga et al substituted numerical values of 8.4 m/s, when "X.XX" was displayed on the monitor [5].…”

Section: Phantom Studymentioning

confidence: 99%

Phantom experiment and clinical utility of quantitative shear wave elastography for differentiating thyroid nodules

et al. 2014

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Recently ultRasonogRaphy equipment has remarkably improved. High-resolution ultrasonography excels in the detection of thyroid lesions, and it is an essential tool for diagnosing thyroid diseases. The present of specific features on B-mode sonography, evaluation of blood flow with Doppler sonography, and the strain ratio measured by strain elastography (SE) provide predictions of tissue characteristics to a certain degree. However, ultrasonography remains suboptimal for diagnosing thyroid diseases [1,2].The novel technology of shear wave elastography (SWE), also known as virtual touch quantification For phantom study, we measured the shear wave velocities (SWVs) of the four spheres of 2-and 1-cm diameters with varying hardness. For clinical study, the SWVs of normal thyroid glands and thyroid nodules, that were classified as benign or malignant according to either cytological or pathological findings, were measured. The SWVs of each thyroid patient were compared with that of a normal thyroid and each other. In phantom study, the SWVs for the 2-cm spheres correlated with the hardness of the targets, whereas the values for the 1-cm spheres did not. In clinical study, 112 nodules identified in 167 patients and 94 normal thyroid glands were analyzed according to the criteria for the study. The nodules included 84 benign nodules, and 28 papillary carcinoma. The mean SWVs of each group were 1.64 ± 0.47 m/s for normal thyroid, 1.88 ± 0.62 m/s for benign nodules and 2.67 ± 0.76 m/s for papillary carcinoma. The SWVs of papillary carcinoma were significantly higher than those of benign nodules (P < 0.001). The area under the ROC curve was 0.809 with a cutoff value of 2.01 m/s. The sensitivity and specificity were 85.7% and 62.0% respectively. Results showed that SWE provides new information on tumor characteristics, such as hardness and larger nodules tended to provide stable measurements.

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“…Virtual touch tissue quantification (VTTQ) is a promising new implementation of acoustic radiation force impulse ultrasound imaging, which provides numerical measurements [shear wave velocity (SWV) values] of tissue stiffness. Up to date, VTTQ has been widely used to evaluate the stiffness of superficial and deep tissues in adults, such as the thyroid gland [2,3], breast [4,5], liver [6][7][8][9], kidneys [6,10], prostate [11,12], and other organs [6]. However, there are only two publications on the topic involving placental stiffness [13,14] and the application of VTTQ in fetuses has not been reported.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

Zheng

Tan

2016

Med Ultrason

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Aims: Virtual touch tissue quantification (VTTQ) has been widely used in adults, but its application in fetuses has not been reported. The purposes of this study were to describe the normal shear wave velocity (SWV) values of fetal brain, lung, and liver by VTTQ and to examine the clinical usefulness of this procedure in evaluation of gestational age-related SWV changes in the fetal brain, lung and liver. Material and methods: One hundred fetuses were enrolled in this study and were evaluated at 18 weeks (second trimester) and 35 weeks (third trimester) during pregnancy. The SWV was measured at the cerebral parenchyma, thalamus, cerebellum, choroid plexus, left lung, right lung, right and left lobe of the liver in each participant. Results: The SWV at the cerebral parenchyma were all significantly greater in the third trimesters than in the second trimesters (3.29±1.05 vs. 2.22±0.97 m/s, p<0.001), while the velocities at thalamus, cerebellum, choroid plexus, left lung, right lung, right lobe of the liver and left lobe of the liver did not differ between the second and the third trimesters (p>0.05). Moreover, the SWV at the cerebral parenchyma correlated significantly with gestational age (r=0.47, p<0.001). Conclusions: VTTQ can provide numerical measurements of fetal brain, lung and liver stiffness and can effectively and objectively indicate gestational age-related changes in cerebral parenchyma stiffness by measuring SWV values.Keywords: fetal tissues, stiffness, gestational age, shear wave velocity, virtual touch tissue quantification A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

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Virtual Touch Tissue Quantification Using Acoustic Radiation Force Impulse Technology

Abstract: Virtual Touch tissue quantification can yield reproducible and quantitative diagnostic information on solid breast masses and serve as an effective diagnostic tool for differentiation between benign and malignant solid masses.

Cited by 125 publications

References 18 publications

Breast elastography: A literature review

Breast elastography: A literature review

Phantom experiment and clinical utility of quantitative shear wave elastography for differentiating thyroid nodules

A novel approach to assessing fetal tissue stiffness using virtual touch tissue quantification.

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