Virucidal properties of new multifunctional fibrous N-halamine-immobilized styrene-divinylbenzene copolymers

Abstract

Virucidal properties of N-chlorosulfonamides immobilized on fibrous styrene-divinylbenzene copolymers have been studied. Corresponding materials with different functional group structures and chlorine content have been synthesized on FIBAN polymer carriers in the form of staple fibers and non-woven fabrics. The study has been conducted in general accordance with EN 14476 standard on poliovirus type-1 and adenovirus type-5. It has been found that all tested samples exhibit pronounced virucidal activity: regardless of the carrier polymer form, sodium N-chlorosulfonamides inactivated both viruses in less than 30 s, and N,N-dichlorosulfonamides—in 30–60 s. The main mechanism of action of these materials, obviously, consists in the emission of active chlorine from the functional group into the treated medium under the action of the amino groups of virus fragments and cell culture. Considering the previously described antimicrobial and reparative properties of such materials, as well as their satisfactory physical and mechanical properties, the synthesized polymers are promising for the creation of medical devices with increased resistance to microbial contamination, such as protective masks, filter elements, long-acting wound dressings, and others.

Broad-Purpose Solutions of N-Chlorotaurine: A Convenient Synthetic Approach and Comparative Evaluation of Stability and Antimicrobial Activity

“…depending on the purpose of the application, which will be the subject of our separate study. Te antimicrobial [9], virucidal [47], and reparative [29] properties of the polymers themselves, and their microbial impermeability [48], together with the data obtained in this study, open up broad prospects for the manufacture of multifunctional medical devices using such materials.…”

Layered Double Hydroxides as the Unique Product of Target Ionic Construction for Energy, Chemical, Foods, Cosmetics, Medicine and Ecology Applications

“…One of the methods for regulating the pharmacological activity of such drugs is their immobilization on various carriers, which can increase the stability of the molecule, protect it from the effects of certain factors (for example, gastric juice when administered orally), and also provide controlled release into the environment, which allows prolonging the effect. Thus, many examples of successful immobilization of antibiotics, [202,203] enzymes, [204,205] peptides, [206,207] halogen-active, [208][209][210] and peroxide [211] preparations on polymeric carriers of various nature have been described. Low toxicity, large surface area, sorption properties, and the possibility of diffusion of the intercalated anion make SDGs promising containers for various microbiocides instead of hard-to-produce polymer bases.…”

New multifunctional bromine-active polymers: synthesis, properties, and antimicrobial activity

“…Materials functionalized in this way contain a significant (up to 13 %) amount of active chlorine, are extremely stable, chemically resistant, and can be repeatedly regenerated. They have been shown to have antimicrobial [52], virucidal [53], and reparative [54] activity. Also there is the possibility of using them to obtain chlorine-active solutions [55].…”