Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo-beta-lactamase-producing isolates

Matin, Fatemeh Zanganeh; Rezatofighi, Seyedeh Elham; Ardakani, Mohammad Roayaei; Akhoond, Mohammad Reza; Mahmoodi, Fahimeh

doi:10.21203/rs.3.rs-487467/v1

Cited by 1 publication

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“…The dramatically increasing rate of multidrug-resistant strains carries a higher risk of treatment failure, entailing increased costs in health care [ 2 , 9 ]. In fact, resistance to carbapenems, a class of antibiotics used to treat some of the most severe bacterial infections, and resistance to colistin, also a last-line antibiotic, have been described in UPEC isolates [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Outer Membrane Proteins in UPEC Antimicrobial Resistance: A Systematic Review

Rodrigues

Rodrigues²,

Duarte

et al. 2022

Membranes

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Uropathogenic Escherichia coli (UPEC) are one of the most common agents of urinary tract infection. In the last decade, several UPEC strains have acquired antibiotic resistance mechanisms and some have become resistant to all classes of antibiotics. UPEC outer membrane proteins (OMPs) seem to have a decisive role not only in the processes of invasion and colonization of the bladder mucosa, but also in mechanisms of drug resistance, by which bacteria avoid killing by antimicrobial molecules. This systematic review was performed according to the PRISMA guidelines, aiming to characterize UPEC OMPs and identify their potential role in antimicrobial resistance. The search was limited to studies in English published during the last decade. Twenty-nine studies were included for revision and, among the 76 proteins identified, seven were associated with antibiotic resistance. Indeed, OmpC was associated with β-lactams resistance and OmpF with β-lactams and fluoroquinolone resistance. In turn, TolC, OmpX, YddB, TosA and murein lipoprotein (Lpp) were associated with fluoroquinolones, enrofloxacin, novobiocin, β-lactams and globomycin resistances, respectively. The clinical implications of UPEC resistance to antimicrobial agents in both veterinary and human medicine must propel the implementation of new strategies of administration of antimicrobial agents, while also promoting the development of improved antimicrobials, protective vaccines and specific inhibitors of virulence and resistance factors.

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