Virulence Determinants of West Nile Virus: How Can These Be Used for Vaccine Design?

Kaiser, Jaclyn A.; Barrett, Alan D.T.

doi:10.2217/fvl-2016-0141

Cited by 16 publications

(16 citation statements)

References 60 publications

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“…WNV neurovirulence and neuroinvasion are typically associated with sequence variations in the flavivirus E protein [124]; strikingly, a unique mutation at position 249 in the helicase portion of NS3 (NS3249P) has been identified in virus strains that have been responsible for major WNV outbreaks during the two last decades [125] and its role in the modulation of WNV virulence and transmission is nowadays largely debated [126,127]. TBEV and LIV TBEV is the most important human tick-borne pathogen in Europe and Asia.…”

Section: Wnvmentioning

confidence: 99%

Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?

Lecollinet

Pronost

Coulpier

et al. 2019

Viruses

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Neurological disorders represent an important sanitary and economic threat for the equine industry worldwide. Among nervous diseases, viral encephalitis is of growing concern, due to the emergence of arboviruses and to the high contagiosity of herpesvirus-infected horses. The nature, severity and duration of the clinical signs could be different depending on the etiological agent and its virulence. However, definite diagnosis generally requires the implementation of combinations of direct and/or indirect screening assays in specialized laboratories. The equine practitioner, involved in a mission of prevention and surveillance, plays an important role in the clinical diagnosis of viral encephalitis. The general management of the horse is essentially supportive, focused on controlling pain and inflammation within the central nervous system, preventing injuries and providing supportive care. Despite its high medical relevance and economic impact in the equine industry, vaccines are not always available and there is no specific antiviral therapy. In this review, the major virological, clinical and epidemiological features of the main neuropathogenic viruses inducing encephalitis in equids in Europe, including rabies virus (Rhabdoviridae), Equid herpesviruses (Herpesviridae), Borna disease virus (Bornaviridae) and West Nile virus (Flaviviridae), as well as exotic viruses, will be presented.

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Section: Wnvmentioning

confidence: 99%

Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?

Lecollinet

Pronost

Coulpier

et al. 2019

Viruses

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“…r At last, a perspective article entitled 'Virulence determinants of West Nile virus: how can these be used for vaccine design?' [7] rounds out the top three.…”

Section: Top Altmetric Articlesmentioning

confidence: 99%

Welcome to the 13th Volume of Future Virology

Thompson

Tebbens²

2018

Future Virol.

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“…Mosquitoes affect people life by inducing big impact through disease transmition such as Rift Valley Fever and West Nile virus (1,2), and their eradication difficulties are devastatingly increasing. These problems induced by different issues such as insecticide resistance (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…PCR amplification of P450 in the gut bacteria of larval mosquitoes after exposure to the BZT Bas.J.Vet.Res.Vol.16, No.2, 2017. ISI Impact Factor:3.461 DISCUSSION Mosquitoes influence the whole world by enhancing disease transmition such as Rift Valley Fever and West Nile virus(1,2). To date, the globe countries face huge obstacles in controlling these creatures.…”

mentioning

confidence: 99%

Activation of Bacterial Cytochrome P450 in the Intestine of Larval Mosquitoes an Indication of Its Role in the Insecticide Resistance

Janabi¹

2017

Bas.J.Vet.Res.

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Mosquitoes apply very important impact on people life, and their control, day by day, is getting harder and harder. This difficulty comes from different issues such as insecticide resistance. The gut microbiome (GM) in different animals has been discovered to add principle influence on the gastrointestinal tract physiology. For example, GM participates in degradation of some poisonus chemicals into safer molecules that could be handled by the animal host. Eukaryotic cytochrome P450 has been detected to inseret some degradation processes in other animal models such as zebra fish. However, these effects are not yet known in mosquitos. In order to stand on these problems and find if the prokaryotic P450 is involved, this study had been done to find out if the GM has any role in developing such resistance in mosquitos. Larvae were used in this experiment which exposed to benzothiozole (BZT) to trigger the hypothetical role of prokaryotic P450. By using polymerase chain reaction (PCR), the result indicates that the bacterial P450 was initiated and might be involved in the BZT exposure handling.

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Virulence Determinants of West Nile Virus: How Can These Be Used for Vaccine Design?

Cited by 16 publications

References 60 publications

Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?

Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe?

Welcome to the 13th Volume of Future Virology

Activation of Bacterial Cytochrome P450 in the Intestine of Larval Mosquitoes an Indication of Its Role in the Insecticide Resistance

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