Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine

Lee, Chaeyeon; Jeong, Jong Hwa; Lee, Taeheon; Zhang, Wei; Xu, Li; Choi, Ji Eun; Park, Ji Hyun; Song, Jae Kwang; Jang, Sinae; Eom, Chi-Yong; Shim, Kyu–Hwan; Soo, A.An Seong; Kang, Young‐Sun; Kwak, Minseok; Jeon, Hae Jeong; Go, Jeung Sang; Suh, Yung Doug; Jin, Jun‐O; Paik, Hyun‐jong

doi:10.1016/j.biomaterials.2018.08.036

Cited by 21 publications

(12 citation statements)

References 42 publications

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“…Morgan et al (2016) [100] suggest that in swine, local lung immunity plays an important role in the protection against influenza. Additionally, Lee et al (2018) [102] developed a polymer-templated protein nanoball with direction-oriented hemagglutinin1 on the surface (H1-NB) as a new influenza vaccine on mice. The authors showed that H1-NB efficiently stimulated H1-specific immune activation, which subsequently prevented H1N1 virus infection in mice.…”

Section: Influenza Antigens Encapsulated In Plga Npsmentioning

confidence: 99%

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

et al. 2021

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The field of veterinary medicine needs new solutions to address the current challenges of antibiotic resistance and the need for increased animal production. In response, a multitude of delivery systems have been developed in the last 20 years in the form of engineered nanoparticles (ENPs), a subclass of which are polymeric, biodegradable ENPs, that are biocompatible and biodegradable (pbENPs). These platforms have been developed to deliver cargo, such as antibiotics, vaccines, and hormones, and in general, have been shown to be beneficial in many regards, particularly when comparing the efficacy of the delivered drugs to that of the conventional drug applications. However, the fate of pbENPs developed for veterinary applications is poorly understood. pbENPs undergo biotransformation as they are transferred from one ecosystem to another, and these transformations greatly affect their impact on health and the environment. This review addresses nanoparticle fate and impact on animals, the environment, and humans from a One Health perspective.

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Section: Influenza Antigens Encapsulated In Plga Npsmentioning

confidence: 99%

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

et al. 2021

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“…By mimicking different modular components of viruses, a multicomponent virus-mimetic nanoparticle was prepared, in which membrane-disrupting peptides, nucleic acid binding components, a protective layer, together with an outer targeting ligand were incorporated for programmed gene delivery (Soliman et al, 2012). Recently, a polymer-templated protein nanoball with well-controlled displaying of HA1 on its surface was prepared as a novel influenza virus-mimetic nanoparticle (Lee et al, 2018). Using silica-based nanoparticles, nonviral nanoparticles mimicking virus surface topography were successfully synthesized by Yu and coworkers, which showed enhanced cellular delivery of small interfering RNA (siRNA) (Niu et al, 2013).…”

Section: Different Biomimetic Nanoparticles Developed For the Treatmementioning

confidence: 99%

“…Intranasal vaccination with this HA-loaded nanodisc elicited a strong anti-HA IgA response, conferring protection against challenge with the influenza (H1N1) virus, with efficacy comparable to that of the commercial vaccines Fluzone and FluMist. In a recent study, a polymer-templated protein nanoball was constructed, displaying HA1 on its surface with controlled orientation and density (Lee et al, 2018). Vaccination with this virus-mimetic polymer nanoparticle protected mice from H1N1 challenge, in the absence of adjuvant.…”

Section: Vaccines Based On Bioinspired Nanoparticlesmentioning

confidence: 99%

Bioinspired and Biomimetic Nanotherapies for the Treatment of Infectious Diseases

2019

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There are still great challenges for the effective treatment of infectious diseases, although considerable achievement has been made by using antiviral and antimicrobial agents varying from small-molecule drugs, peptides/proteins, to nucleic acids. The nanomedicine approach is emerging as a new strategy capable of overcoming disadvantages of molecular therapeutics and amplifying their anti-infective activities, by localized delivery to infection sites, reducing off-target effects, and/or attenuating resistance development. Nanotechnology, in combination with bioinspired and biomimetic approaches, affords additional functions to nanoparticles derived from synthetic materials. Herein, we aim to provide a state-of-the-art review on recent progress in biomimetic and bioengineered nanotherapies for the treatment of infectious disease. Different biomimetic nanoparticles, derived from viruses, bacteria, and mammalian cells, are first described, with respect to their construction and biophysicochemical properties. Then, the applications of diverse biomimetic nanoparticles in anti-infective therapy are introduced, either by their intrinsic activity or by loading and site-specifically delivering various molecular drugs. Bioinspired and biomimetic nanovaccines for prevention and/or therapy of infectious diseases are also highlighted. At the end, major translation issues and future directions of this field are discussed.

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“…HA is a highly conserved surface protein found in various influenza virus strains. Such repetitive HAs mimic the natural structure of influenza virus, resulting in cross-protection and effective prevention from influenza infections [57] .…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Advanced drug delivery systems can assist in managing influenza virus infection: A hypothesis

Chan

Mehta

et al. 2020

Medical Hypotheses

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Outbreaks of influenza infections in the past have severely impacted global health and socioeconomic growth. Antivirals and vaccines are remarkable medical innovations that have been successful in reducing the rates of morbidity and mortality from this disease. However, the relentless emergence of drug resistance has led to a worrisome increase in the trend of influenza outbreaks, characterized by worsened clinical outcomes as well as increased economic burden. This has prompted the need for breakthrough innovations that can effectively manage influenza outbreaks. This article provides an insight into a novel hypothesis that describes how the integration of nanomedicine, with the development of drugs and vaccines can potentially enhance body immune response and the efficacies of anti-viral therapeutics to combat influenza infections.

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Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine

Cited by 21 publications

References 42 publications

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Bioinspired and Biomimetic Nanotherapies for the Treatment of Infectious Diseases

Advanced drug delivery systems can assist in managing influenza virus infection: A hypothesis

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