Virus Particles in Epithelial Cells of Duodenal Mucosa From Children With Acute Non-Bacterial Gastroenteritis

Bishop, R. F.; Davidson, Garry J.; Holmes, Ian; Ruck, B. J.

doi:10.1016/s0140-6736(73)92867-5

Cited by 887 publications

(446 citation statements)

References 14 publications

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“…After the publication of Bishop et al (1973), showing the presence of rotavirus-like particles in stools of infants with acute gastrAnteritis, many publications have shown considerable evidence that this virus is the aetiologic agent involved in a large proportion ofthe diarrhoea of infants and children (Albrey & Murphy, 1976;Hieber et al 1978;Pickering et al 1978). Rotavirus has also been shown to occur in adults (WHO, 1981;Bonsdorff et at.…”

Section: Discussionmentioning

confidence: 99%

An outbreak of gastroenteritis caused by both rotavirus andShigella sonneiin a private school in Rio de Janeiro

Sutmoller

Azeredo

Lacerda

et al. 1982

J. Hyg.

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SUMMARYIn May 1980 an extensive outbreak ofgastroenteritis occurred in a private school in the city of Rio de Janeiro. Examination of faeces and paired sera showed that this outbreak was caused by both rotavirus and a virulent strain of Shigella sonnei.In the first 19 stool samples collected seven (37 %) had rotavirus only, six (32 %) had Sh. sonnei only, while four (21 %) had both agents. Examination of the second and third stool collections revealed only the presence of Sh. sonnei. The 18 paired sera showed seroconversion for rotavirus in four cases (22 %) and in seven cases (39 %) for Sh. sonnei. The overall attack rate ofthe disease was approximately 75 %, the nursery and kindergarten having higher attack rates. Students in all grades became sick at the same time, and the unimodal curve of the onset dates of symptoms indicates a common source outbreak. Evidence suggested a contaminated water supply.

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Section: Discussionmentioning

confidence: 99%

An outbreak of gastroenteritis caused by both rotavirus andShigella sonneiin a private school in Rio de Janeiro

Sutmoller

Azeredo

Lacerda

et al. 1982

J. Hyg.

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“…Bishop and her colleagues first reported the observation of rotavirus particles (referred to as reovirus, reovirus-like, duovirus and orbivirus by previous workers) in the duodenal mucosa of children with non-bacterial enteritis (Bishop et al 1973). The virus is now recognized as a major cause of diarrhoea in man and animals.…”

Section: Discussionmentioning

confidence: 99%

Virus diarrhoea associated with pale fatty faeces

Thomas

Luton

Mortimer

1981

J. Hyg.

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SUMMARYSteatorrhoea was a significant feature in an outbreak of rotavirus gastroenteritis which affected adults and infants in hospital. Fat globules or fatty acid crystals were obvious by light microscopy (LM) in faeces from 14 of 25 patients examined. Ten of the fatty stools and two of the remainder were very pale. By electron microscopy (EM) a rotavirus was seen in 11 of the 14 fatty faeces and in only two of 11 specimens without visible fat.In a further study of pale or fatty faeces 20 such specimens sent for laboratory examination from patients not involved in the hospital outbreak were compared microbiologically with a similar number which were neither pale nor fatty. Viruses were found by EM in 11 (55 %) of the pale or fatty stools; eight rotaviruses, two astroviruses and an uncultivable adenovirus were seen; one further patient had acute jaundice. In contrast, no viruses were seen by EM in the twenty specimens which were normally pigmented and without evident fat.Steatorrhoea was significantly associated with rotavirus infection of the alimentary tract which usually presented as a fatty enteritis. We conclude that rotaviruses certainly, and other viruses possibly, can impede both the digestion of fat and the pigmentation of the faeces. Inspection and LM of faeces are easy. In acute enteritis a fatty or pale stool is an indication for virological examination.

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“…After 37 generations, the LLR vaccine has proved to consist of monovalent serotype of (P [12]G [10]), group A [5]. This RV vaccine was licensed formally for gastroenteritis prevention (group A rotavirus) among children in China in 2000.…”

Section: Llrmentioning

confidence: 99%

“…Abundant viral particles were identified in the epithelial cells lining the upper villous surface [12]. The virus was identified as being reovirus-like/orbivirus-like, with a close resemblance to viruses already implicated as cause of diarrhea in neonatal mice [1], and in calves [54].…”

Section: Introductionmentioning

confidence: 99%

Rotavirus Infection: A Perspective on Epidemiology, Genomic Diversity and Vaccine Strategies

Mukherjee

Chawla‐Sarkar

2011

Indian J. Virol.

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Virus Particles in Epithelial Cells of Duodenal Mucosa From Children With Acute Non-Bacterial Gastroenteritis

Cited by 887 publications

References 14 publications

An outbreak of gastroenteritis caused by both rotavirus andShigella sonneiin a private school in Rio de Janeiro

An outbreak of gastroenteritis caused by both rotavirus andShigella sonneiin a private school in Rio de Janeiro

Virus diarrhoea associated with pale fatty faeces

Rotavirus Infection: A Perspective on Epidemiology, Genomic Diversity and Vaccine Strategies

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