2003
DOI: 10.1016/s0074-7742(03)01001-8
|View full text |Cite
|
Sign up to set email alerts
|

Virus Vectors for use in the Central Nervous System

Abstract: For many years it has been virtually impossible to transfer genes into brain cells either to study or manipulate molecular, cellular, or, in vivo, behavioral processes. In addition to the physical barriers that protect the brain (bone and three layers of meninges), the earliest gene delivery systems, the retroviral vectors, require cell division to integrate the transgenes into their genomes to express any transgenes. Thus they limited transduction to dividing cells of the nervous system, e.g., astrocytes and … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2005
2005
2020
2020

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 8 publications
(1 citation statement)
references
References 320 publications
(222 reference statements)
0
1
0
Order By: Relevance
“…We used high titer purified adenovirus to express the cytoFTMT gene under a strong CMV promoter in vivo . AdV does not integrate into the host chromosomes, and its episomal plasmid propagation can deliver very high levels of transgene expression due to a high copy number of plasmid per cell [27]. In addition, AdV is known to preferentially target the olfactory epithelium [28].…”
Section: Discussionmentioning
confidence: 99%
“…We used high titer purified adenovirus to express the cytoFTMT gene under a strong CMV promoter in vivo . AdV does not integrate into the host chromosomes, and its episomal plasmid propagation can deliver very high levels of transgene expression due to a high copy number of plasmid per cell [27]. In addition, AdV is known to preferentially target the olfactory epithelium [28].…”
Section: Discussionmentioning
confidence: 99%