Viruses and oral squamous carcinoma

Scully, Crispian

doi:10.1016/0964-1955(92)90014-r

Cited by 29 publications

(8 citation statements)

References 46 publications

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“…In the present study, no information was available with regard to the duration and changes of smoking and alcohol drinking habits. Furthermore, other possible etiological factors and cofactors mentioned in the literature, such as the state of the dentition (17,18), mouthwash use (19), nutrition (20), viral infections (21) or professional occupation (22), have not been included in the present investigation.…”

Section: Discussionmentioning

confidence: 99%

Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma

Jovanovic¹,

Schulten²,

Kostense³

et al. 1993

J Oral Pathology Medicine

100

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The aim of the present study was to evaluate the possible relationship between tobacco smoking and alcohol drinking and the anatomical sites of squamous cell carcinoma (SCC) of the lip and oral cavity. For this purpose, a case-case study has been performed in 690 patients. The study was focused on the relative risk (RR) or developing SCC at various (sub)sites, for smokers and drinkers of alcohol (divided into moderate and heavy users) relative to non-smokers and non-drinkers. Estimates of ratios of these relative risks were obtained. The relative risk associated with tobacco smoking, adjusted for the use of alcohol, appeared to be highest for SCC in the retromolar area, followed by the floor of mouth, whereas the lowest RR was found in the cheek mucosa. For alcohol drinking, adjusted for tobacco smoking, RR of SCC of the floor of mouth was significantly higher than for the tongue, whereas the RR of SCC of the cheek appeared to be lowest. Furthermore, this study suggests that the contrasts between relative risks, observed by anatomical site of oral SCC, are more pronounced for tobacco smoking than for the use of alcohol. The possible local and systemic factors responsible for these variations of susceptibility for tobacco and alcohol within the oral cavity are discussed.

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Section: Discussionmentioning

confidence: 99%

Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma

Jovanovic¹,

Schulten²,

Kostense³

et al. 1993

J Oral Pathology Medicine

100

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“…Several etiological factors-for oral cancer and for subsequent development of second tumors-have been identified, such as smoking, alcohol consumption, genetic factors, mutagen sensitivity, dietary factors, occupation and viral infections (De Vries, 1990;Schantz et al, 1990;Scully, 1992). To minimize the risk of developing MPT, all patients should be advised to quit smoking and to stop drinking alcohol, also to include consumption of fruit and vegetables in their diet.…”

Section: Discussionmentioning

confidence: 99%

Risk of multiple primary tumors following oral squamous‐cell carcinoma

Jovanoic

Tol

Schulten

et al. 1994

Intl Journal of Cancer

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The follow-up of 727 patients with squamous-cell carcinoma (SCC) of the lip and oral cavity has been used for the risk analysis of multiple primary tumors (MPTs) following SCC of the lip and oral cavity. Age-, gender- and site-specific cancer-incidence rates from the general population have been applied to the appropriate persons-years of follow-up of patients with SCC of the lip and oral cavity. The study indicates that patients with a primary SCC of the lip and oral cavity have, compared with the general population, a significantly elevated risk of developing an additional cancer of the oral cavity and/or pharynx, the risk being 74.7-fold for males and 190.4-fold for females. Furthermore, a 24.6 and 45.3 times higher risk of an additional esophageal tumor was found in males and females respectively. The risk of cancer of the lung and pharynx was less elevated compared with the risk of cancer of the upper digestive tract. No elevated risks were established in organs outside the respiratory and upper digestive tract.

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“…Other aetiological factors such as diet [46,47], oral hygiene and dentition [48,49], mouthwashes [50,51] and viral infections [52,53] have also been identi®ed but their role is inconsistent.…”

Section: Risk Factorsmentioning

confidence: 99%

Oral cancer in the UK: to screen or not to screen

1998

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Although oral squamous cell carcinoma accounts for only a small proportion of malignant neoplasms in the UK, oral cancer incidence and mortality rates have been rising in recent years. The natural history of oral cancer is not adequately understood at present and there is very little information about the epidemiology of precancerous lesions in the UK. There are also insucient data to provide ®rm evidence that the percentage of cases arising de novo is greater in the UK and the Western world as compared to the Indian subcontinent. Screening for oral cancer by visual examination is simple, inexpensive and causes little discomfort; however, there is no evidence for the eectiveness of screening for oral cancer either in reducing mortality from the disease or in reducing the incidence of invasive disease by detection and treatment of precancerous lesions. There is currently insucient evidence to recommend population screening for oral cancer in the UK. Measures aimed at primary prevention of the disease may be a more feasible method of disease control at present. #

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Viruses and oral squamous carcinoma

Cited by 29 publications

References 46 publications

Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma

Tobacco and alcohol related to the anatomical site of oral squamous cell carcinoma

Risk of multiple primary tumors following oral squamous‐cell carcinoma

Oral cancer in the UK: to screen or not to screen

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