Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Leta, Valentina; Urso, Daniele; Batzu, Lucia; Lau, Yue Hui; Mathew, Donna; Boura, Iro; Raeder, Vanessa; Falup-Pecurariu, Cristian; van Wamelen, Daniel; Ray Chaudhuri, K.

doi:10.1007/s00702-022-02536-y

Cited by 37 publications

(32 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The currently available evidence on viral-induced Parkinsonism with a focus on potential pathophysiological mechanisms and clinical features and the evidence of viral infections as a risk factor for developing PD has recently been reviewed by Chaudhuri and co-workers (Leta et al 2022 ). It is conceivable that particular agents (among them probably neurotropic viruses) could initiate neurodegenerative disorders of protein aggregation, including PD.…”

Section: Discussionmentioning

confidence: 99%

The heterogeneity of Parkinson’s disease

et al. 2023

View full text Add to dashboard Cite

The heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design. We outline several pathophysiological concepts, pathways and mechanisms, including the presumed roles of α-synuclein misfolding and aggregation, Lewy bodies, oxidative stress, iron and melanin, deficient autophagy processes, insulin and incretin signaling, T-cell autoimmunity, the gut–brain axis and the evidence that microbial (viral) agents may induce molecular hallmarks of neurodegeneration. The hypothesis is discussed, whether PD might indeed be triggered by exogenous (infectious) agents in susceptible individuals upon entry via the olfactory bulb (brain first) or the gut (body-first), which would support the idea that disease mechanisms may change over time. The unresolved heterogeneity of PD may have contributed to the failure of past clinical trials, which attempted to slow the course of PD. We thus conclude that PD patients need personalized therapeutic approaches tailored to specific phenomenological and etiologic subtypes of disease.

show abstract

Section: Discussionmentioning

confidence: 99%

The heterogeneity of Parkinson’s disease

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The immediate response is thought to be mediated by direct or indirect effects of viral infection including immunopathological damage, whereas para-infectious parkinsonism might have its origin in pathogen-induced autoimmunity, possibly involving B cell activation. 11 Given our patient's autoimmune predisposition, autoimmune mediation seemed possible but no evidence of an autoimmune etiology was detected. Moreover, autoimmune parkinsonism appears less likely given the lack of response to steroids and the preexisting complete B cell depletion due to rituximab.…”

Section: Discussionmentioning

confidence: 81%

Parkinsonism due to Coxsackie B Virus Infection—Case Report and Literature Review

Vlad,

Jelcic,

Balint

2023

Movement Disord Clin Pract

View full text Add to dashboard Cite

“…The correlation between the frequency of influenza episodes and the chance of having parkinsonism suggests that influenza-correlated brain damage could be an accumulating inflammatory process [ 51 ]. People with a vulnerable genetic constitution could have mitochondrial damage caused immunologically and neural oxidative stress [ 52 ].…”

Section: Infectious Risk Variablesmentioning

confidence: 99%

Infectious Microorganisms Seen as Etiologic Agents in Parkinson’s Disease

Stroe

Jurja

Mehedinți

et al. 2023

Life

View full text Add to dashboard Cite

Infections represent a possible risk factor for parkinsonism and Parkinson’s disease (PD) based on information from epidemiology and fundamental science. The risk is unclear for the majority of agents. Moreover, the latency between infection and PD seems to be very varied and often lengthy. In this review, the evidence supporting the potential involvement of infectious microorganisms in the development of Parkinson’s disease is examined. Consequently, it is crucial to determine the cause and give additional treatment accordingly. Infection is an intriguing suggestion regarding the cause of Parkinson’s disease. These findings demonstrate that persistent infection with viral and bacterial microorganisms might be a cause of Parkinson’s disease. As an initiating factor, infection may generate a spectrum of gut microbiota dysbiosis, engagement of glial tissues, neuroinflammation, and alpha-synuclein accumulation, all of which may trigger and worsen the onset in Parkinson’s disease also contribute to its progression. Still uncertain is the primary etiology of PD with infection. The possible pathophysiology of PD infection remains a matter of debate. Furthermore, additional study is required to determine if PD patients develop the disease due to infectious microorganisms or solely since they are more sensitive to infectious causes.

show abstract

Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Cited by 37 publications

References 138 publications

The heterogeneity of Parkinson’s disease

The heterogeneity of Parkinson’s disease

Parkinsonism due to Coxsackie B Virus Infection—Case Report and Literature Review

Infectious Microorganisms Seen as Etiologic Agents in Parkinson’s Disease

Contact Info

Product

Resources

About