Viruses, Polymerases, and Cancer

Baltimore, David

doi:10.1126/science.57644

Cited by 51 publications

(7 citation statements)

References 77 publications

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“…This distinguishes between double-stranded DNA viruses, single-stranded DNA viruses, positive-sense double-stranded RNA viruses, negative-sense single-stranded RNA viruses (the genome of RNA viruses can be coded in two different directions: either in the 5’–3’ direction, like messenger RNA, corresponding to positive-sense, or in the reverse direction corresponding to negative-sense) and retroviruses [4] . One of the smallest known viruses measures 10 nanometres and its genome contains only one gene: hepatitis delta virus (which, moreover, is considered to be a satellite virus of the hepatitis B virus, as it can only replicate in a patient already infected with hepatitis B virus or in the presence of simultaneous contamination with hepatitis B virus and hepatitis D virus) [5] .…”

Section: Structure Of Viral Particlesmentioning

confidence: 99%

Viruses and viral epidemics in the metabolic theory of evolution

Jankowski

2020

European Annals of Otorhinolaryngology, Head and Neck Diseases

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Viruses, including the SARS-CoV-2 virus responsible for the current COVID-19 epidemic, are a key to the understanding of life and evolution. Cells may have arisen from aqueous sequestration inside a lipid envelope studded with chromophores capable of capturing solar photons. Nitrogen incorporation in the primordial cell chemistry allowed synthesis of amino acids and nucleic acids, a prelude to RNA and subsequently DNA. Metagenomics provides access to nucleoprotein sediments synthesised by a googol of metabolically differentiated cells that have marked the evolution of life. Replication of a virus, a nucleoprotein particle, occurs passively in competent cells. Viruses are only identified in the context of the epidemic that they induce as a result of transmission from one host to another. By breaking down the viral particle, the host cell appears to resurrect the metabolic function of the nucleic acid, which synthesises its components without any form of control. Viral products undergo self-assembly and are exported by either exocytosis or cytolysis. In the absence of cells, viruses appear to be inert. However, intracellular contamination of a virus does not always result in replication: the viral genome can disappear, remain latent, wake up, remain embedded in the cellular genome, become an oncogene or induce auto-immunity. The presence of endogenous retroviruses in eukaryotic cells raises the question of their possible role in evolution.

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Section: Structure Of Viral Particlesmentioning

confidence: 99%

Viruses and viral epidemics in the metabolic theory of evolution

Jankowski

2020

European Annals of Otorhinolaryngology, Head and Neck Diseases

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“…This ran against the prevailing dogma that DNA led to RNA and thence to proteins. Temin and Baltimore (14, 15) went on to independently demonstrate that this occurred through the intermediary of reverse transcriptase.…”

Section: Drug Development and The Application Of Sciencementioning

confidence: 99%

Drug evaluation, drug development and pharmacogenetics: celebrating 30 years of progress

2005

J Clin Pharm Ther

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“…It is reasonable to wonder why reverse transcriptase was not discovered earlier. In their Nobel Prize lectures, Baltimore 22 and Temin 23 acknowledged that the existence of a DNA polymerase could have been deduced in 1967 or 1968.…”

Section: Commentarymentioning

confidence: 99%

Viral RNA‐dependent DNA polymerase RNA‐dependent DNA polymerase in virions of Rous sarcoma virus

Weiss

1998

Rev. Med. Virol.

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Viruses, Polymerases, and Cancer

Cited by 51 publications

References 77 publications

Viruses and viral epidemics in the metabolic theory of evolution

Viruses and viral epidemics in the metabolic theory of evolution

Drug evaluation, drug development and pharmacogenetics: celebrating 30 years of progress

Viral RNA‐dependent DNA polymerase RNA‐dependent DNA polymerase in virions of Rous sarcoma virus

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