Viruslike Nanoparticles with Maghemite Cores Allow for Enhanced MRI Contrast Agents

Malyutin, Andrey; Easterday, Rosemary; Lozovyy, Yaroslav; Spilotros, Alessandro; Cheng, Hu; Sanchez-Felix, Olivia R.; Stein, Barry D.; Morgan, David; Svergun, Dmitri I.; Dragnea, Bogdan; Bronstein, Lyudmila M.

doi:10.1021/cm504029j

Cited by 33 publications

(28 citation statements)

References 53 publications

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“…This is highly comparable to the clinically used MRI contrast agent such as Feridex 105 mM −1 s −1 65 , which shows noticeable changes after injecting iron oxide NPs 66 . Therefore this confirmed that the Au nanoshell around Nk did not play a role in Nk core spin 67 . But the r 2 value with Hep2 cells showed significant increment when compared to L6 cells because of gold iterations.…”

Section: Resultssupporting

confidence: 62%

Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics

Ravichandran

Oza

Velumani

et al. 2016

Sci Rep

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A multifunctional magneto-plasmonic CoFe2O4@Au core-shell nanoparticle was developed by iterative-seeding based method. This nanocargo consists of a cobalt ferrite kernel as a core (Nk) and multiple layers of gold as a functionalizable active stratum, (named as Nk@A after fifth iteration). Nk@A helps in augmenting the physiological stability and enhancing surface plasmon resonance (SPR) property. The targeted delivery of Doxorubicin using Nk@A as a nanopayload is demonstrated in this report. The drug release profile followed first order rate kinetics optimally at pH 5.4, which is considered as an endosomal pH of cells. The cellular MR imaging showed that Nk@A is an efficient T2 contrast agent for both L6 (r2-118.08 mM−1s−1) and Hep2 (r2-217.24 mM−1s−1) cells. Microwave based magnetic hyperthermia studies exhibited an augmentation in the temperature due to the transformation of radiation energy into heat at 2.45 GHz. There was an enhancement in cancer cell cytotoxicity when hyperthermia combined with chemotherapy. Hence, this single nanoplatform can deliver 3-pronged theranostic applications viz., targeted drug-delivery, T2 MR imaging and hyperthermia.

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Section: Resultssupporting

confidence: 62%

Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics

Ravichandran

Oza

Velumani

et al. 2016

Sci Rep

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“…14, 20 Additionally, fundamental understanding of the interactions involved in particle self-assembly informed the fabrication of novel imaging agents (see Section 4.1.2 ). 21, 22 Through multidisciplinary collaboration, the use of viral scaffolds as unique materials for diverse applications can be realized.…”

Section: Viruses In a Materials Worldmentioning

confidence: 99%

Design of virus-based nanomaterials for medicine, biotechnology, and energy

2016

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Virus-based nanomaterials are versatile materials that naturally self-assemble and have relevance for a broad range of applications including medicine, biotechnology, and energy. This review provides an overview of recent developments in “chemical virology.” Viruses, as materials, provide unique nanoscale scaffolds that have relevance in chemical biology and nanotechnology, with diverse areas of applications. Some fundamental advantages of viruses, compared to synthetically programmed materials, include the highly precise spatial arrangement of their subunits into a diverse array of shapes and sizes and many available avenues for easy and reproducible modification. Here, we will first survey the broad distribution of viruses and various methods for producing virus-based nanoparticles, as well as engineering principles used to impart new functionalities. We will then examine the broad range of applications and implications of virus-based materials, focusing on the medical, biotechnology, and energy sectors. We anticipate that this field will continue to evolve and grow, with exciting new possibilities stemming from advancements in the rational design of virus-based nanomaterials.

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“…Over the years a variety of protein cages, in particular viruses, have been studied for their application in nanotechnology, which has yielded knowledge about their biological, chemical, and physical properties . Due to their diversity, homogeneity, and well‐defined dimensional properties, there is increasing interest in the use of viruses or virus‐like particles (VLPs), for example, in the fields of biomedicine, materials science, and nanotechnology . Some examples of this work involve encapsulating non‐native cargo such as enzymes, polymers, or metal nanoparticles .…”

Section: Introductionmentioning

confidence: 99%

Experimental and Theoretical Determination of the pH inside the Confinement of a Virus‐Like Particle

Maassen

Schoot

Cornelissen

2018

Small

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In biology, a variety of highly ordered nanometer-size protein cages is found. Such structures find increasing application in, for example, vaccination, drug delivery, and catalysis. Understanding the physiochemical properties, particularly inside the confinement of a protein cage, helps to predict the behavior and properties of new materials based on such particles. Here, the relation between the bulk solution pH and the local pH inside a model protein cage, based on virus-like particles (VLPs) built from the coat proteins of the cowpea chlorotic mottle virus, is investigated. The pH is a crucial parameter in a variety of processes and is potentially significantly influenced by the high concentration of charges residing on the interior of the VLPs. The data show a systematic more acidic pH of 0.5 unit inside the VLP compared to that of the bulk solution for pH values above pH 6, which is explained using a theoretical model based on a Donnan equilibrium. The model agrees with the experimental data over almost two orders of magnitude, while below pH 6 the experimental data point to a buffering capacity of the VLP. These results are a first step in a better understanding of the physiochemical conditions inside a protein cage.

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Viruslike Nanoparticles with Maghemite Cores Allow for Enhanced MRI Contrast Agents

Cited by 33 publications

References 53 publications

Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics

Plasmonic/Magnetic Multifunctional nanoplatform for Cancer Theranostics

Design of virus-based nanomaterials for medicine, biotechnology, and energy

Experimental and Theoretical Determination of the pH inside the Confinement of a Virus‐Like Particle

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