Vis-NIR spectroscopic and clinical evaluations of the response of spider leg veins to a high-powered pulsed-diode-laser (810 nm) therapy

Schmidt, W.; Konrad, H; Scheibe, Armin; Haroske, Gunther; Zimmermann, Gabriele; Astafyeva, L. G.; Wollina, Uwe; Faßler, D.

doi:10.1117/12.499150

Cited by 3 publications

(5 citation statements)

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“…There is a good correlation between the change of remission spectra and microcirculation. [27][28][29] The relative oxygen saturation (SpO 2 ) can be calculated according to Mannheimer et al 27,28 and expressed as a percentage:…”

Section: Wollina Et Almentioning

confidence: 99%

Some Effects of a Topical Collagen-Based Matrix on the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations

Wollina

Schmidt²,

Krönert

et al. 2005

The International Journal of Lower Extremity Wounds

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The microcirculation of the wound bed is a key parameter for improving granulation tissue formation and, hence, wound healing. The aim of this study was to determine whether a wound dressing comprising collagen/oxidized regenerated cellulose has effects over a short term on wound healing. Wounds were evaluated using a clinical wound score; pain associated with wounds was measured using a visual analogue scale. Wound microcirculation was evaluated using a technique based on noncontact remission spectroscopy. A prospective trial was performed in 40 patients with chronic venous leg ulcers (mean age 74 years; range, 43-93 years; 25 females and 15 males). Patients in group A were treated with PROMOGRAN Matrix (Johnson& Johnson, New Brunswick, NJ) combined with "good" ulcer care for 2 weeks. Control group B consisted of 10 patients who received only good ulcer care. The authors measured a favorable clinical response in 76.9% (group A) versus 66.7% (group B). The mean reduction of ulcer area was statistically significant in group A (P < .05). The wound score improved in group A from 2.28 +/- 1.24 (before treatment) increasing to 3.72 +/- 1.57 (after 1 week; P < .00023) and 4.92 +/- 1.68 (after 2 weeks; P < .000027). In group B, the score improved from 1.44 +/- 1.33 (before treatment) to 3.22 +/- 1.30 (after 1 week; P < .0077). The mean visual analogue pain score before treatment was 8.72 (group A) and 7.88 (group B) (ns, P > .05). After 1 week of treatment, the score dropped to 5.76 (group A) and 6.66 (group B). In the second week, group A patients had a mean pain score of 3.84 compared with the pain score before treatment (P < .05). After 1 week of treatment, in group A there was a decrease in remission spectroscopy, which is considered to reflect an improvement in microcirculation.

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Section: Wollina Et Almentioning

confidence: 99%

Some Effects of a Topical Collagen-Based Matrix on the Microcirculation and Wound Healing in Patients With Chronic Venous Leg Ulcers: Preliminary Observations

Wollina

Schmidt²,

Krönert

et al. 2005

The International Journal of Lower Extremity Wounds

Self Cite

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“…The deeper vessels show a substantially decreased maximum heating temperature. Increase of the vessel size lead initially to an increase of the maximum temperature inside but from a radius of about 0.3 mm, the maximum heating temperature becomes stable 18,19 …”

Section: Theoretical Considerationsmentioning

confidence: 99%

“… 18,43,44 As demonstrated by histological examinations, the inflammatory reaction is very limited which might be responsible for the excellent safety profile. Remission spectroscopy studies in vivo have demonstrated an immediate disappearance of the vascular signal 18,19 …”

Section: Theoretical Considerationsmentioning

confidence: 99%

“…Increase of the vessel size lead initially to an increase of the maximum temperature inside but from a radius of about 0.3 mm, the maximum heating temperature becomes stable. 18,19 Irreversible laser coagulation needs an intravascular temperature between 45 ° C and 100 ° C. In vitro studies suggest a three-phase model consisting of a heating phase, primary coagulation and secondary coagulation. Denaturation of haemoglobin and formation of smallsized Mie particles is observed during the first phase.…”

Section: Pulse Durationmentioning

confidence: 99%

“…Remission spectroscopy studies in vivo have demonstrated an immediate disappearance of the vascular signal. 18,19 The pulsed diode lasers have been shown to be very effective but with lesser pain than Nd:YAG laser in recent studies. Better results are obtained with 0.8-2 mm spider leg veins.…”

Section: Pulsed Diode Lasermentioning

confidence: 99%

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