Visceral adipose tissue quality was associated with nonalcoholic fatty liver disease, independent of its quantity

Igarashi, Yusuke; Tanaka, Muhei; Okada, Hiroshi; Hashimoto, Yoshitaka; Kumagai, Muneaki; Yamaoka, Miyoko; Nishimura, Hiromi; Fukui, Michiaki

doi:10.1016/j.numecd.2022.01.009

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…Therefore, the increase in vertebral marrow fat may reflect the progression of osteoporosis. Our findings are consistent with previous studies revealing that the menopause transition is associated with increased central adiposity ( 6 , 36 , 40 ) and confirmed a higher incidence of osteoporosis in postmenopausal women than in premenopausal women.…”

Section: Discussionsupporting

confidence: 93%

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

et al. 2023

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PurposeTo assess abdominal fat deposition and lumbar vertebra with iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) and investigate their correlation with menopausal status.Materials and MethodsTwo hundred forty women who underwent routine abdominal MRI and IDEAL-IQ between January 2016 and April 2021 were divided into two cohorts (first cohort: 120 pre- or postmenopausal women with severe fatty livers or without fatty livers; second cohort: 120 pre- or postmenopausal women who were obese or normal weight). The fat fraction (FF) values of the liver (FFliver) and lumbar vertebra (FFlumbar) in the first group and the FF values of subcutaneous adipose tissue (SAT) (FFSAT) and FFlumbar in the second group were measured and compared using IDEAL-IQ.ResultsTwo hundred forty women were evaluated. FFlumbar was significantly higher in both pre- and postmenopausal women with severe fatty liver than in patients without fatty livers (premenopausal women: p < 0.001, postmenopausal women: p < 0.001). No significant difference in the FFlumbar was observed between obese patients and normal-weight patients among pre- and postmenopausal women (premenopausal women: p = 0.113, postmenopausal women: p = 0.092). Significantly greater lumbar fat deposition was observed in postmenopausal women than in premenopausal women with or without fatty liver and obesity (p < 0.001 for each group). A high correlation was detected between FFliver and FFlumbar in women with severe fatty liver (premenopausal women: r=0.76, p<0.01; postmenopausal women: r=0.82, p<0.01).ConclusionFat deposition in the vertebral marrow was significantly associated with liver fat deposition in postmenopausal women.

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Section: Discussionsupporting

confidence: 93%

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

et al. 2023

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“…The search from PubMed Central and ScienceDirect initially yielded 97,511 results altogether. After excluding duplicates and identifying records to be screened, 16,000 journals were screened by their title and abstracts for keywords before 50 full-text articles were assessed for 20 studies [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] eventually being accounted in this review.…”

Section: Search Resultsmentioning

confidence: 99%

“…It should also be noted that the association result shown for the measurement unit of the VAT increase was not constant. While one study showed the result for a per-cm increase in VAT [29], some showed a cm 2 increase [40,47], some showed a 1-SD increase in volume (L) [43], and some calculated into and used the VFA index as per 1.0 cm 2 /m 2 increase [45]. However, VAT was analyzed independently of its association with NAFLD in these studies, and the consistency of the results proved the reproducibility of the positive association between VAT and NAFLD regardless of the measurement unit.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review

Seaw,

Henry,

2023

Livers

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Imaging-based body composition analysis can quantify visceral fat, which is an important feature of lean non-alcoholic fatty liver disease (NAFLD) patients. This review assesses current evidence of the relationship between NAFLD, particularly hepatic steatosis, and visceral fat that is measured using imaging-based body composition analysis. PubMed Central and ScienceDirect were searched for studies that provided quantification of the relationship between NAFLD, hepatic steatosis and visceral fat. Twenty studies comprising 15,763 subjects were included, consisting of the relationship with NAFLD (n = 15) and the relationship with hepatic steatosis (n = 7). All studies reported a positive relationship between NAFLD and visceral fat. For hepatic steatosis regardless of severity, only one study reported no correlation with visceral fat. Further results showed that visceral fat is more related to NAFLD and hepatic steatosis in females than males. More studies including NAFLD of different stages must be performed in the future to validate the degree of association between visceral fat and NAFLD at all stages as well as this relationship difference between genders.

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“…Even without representing a clinical consensus, several studies conducted in general populations reported that hepatic steatosis [49][50][51][52] and EAT [14,15,53,54] are positively associated with VAT and have the potential to estimate intra-abdominal fat stores. To the best of our knowledge, our controlled study assessing the association between hepatic steatosis and VAT in patients with PCOS adds novelty to this area of interest.…”

Section: Discussionmentioning

confidence: 99%

Visceral Adipose Tissue, Epicardial Fat, and Hepatic Steatosis in Polycystic Ovary Syndrome: A Study of Ectopic Fat Stores and Metabolic Dysfunction

Cavalcante,

Leão,

Tavares

et al. 2024

Preprint

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Purpose: Ectopic fat accumulation remains a topic of debate in polycystic ovary syndrome (PCOS). Therefore, intra-abdominal, hepatic, and epicardial fat were compared between PCOS women and body mass index (BMI)-matched controls, and their associations with metabolic and hormonal parameters were explored. Furthermore, the performance of echocardiographic epicardial adipose tissue thickness (EATT) and hepatic steatosis measurement by transient elastography-based controlled attenuation parameter (TE-CAP) in screening abdominal visceral adipose tissue (VAT) was evaluated. Methods: Women aged 18–39 years with BMI < 35 kg/m² were recruited. PCOS was defined by the Rotterdam criteria. All participants underwent clinical and laboratory exams, dual-energy X-ray absorptiometry (DXA), TE-CAP, and echocardiography. A receiver operating characteristic curve was applied to evaluate accuracy and optimal cutoff values of TE-CAP and EATT in predicting DXA-measured VAT. Results: The study included 72 volunteers (35 with PCOS, 37 controls). PCOS women exhibited higher levels of androgens, insulin resistance (IR) parameters, LDL-cholesterol, triglycerides, VAT, and EATT. VAT correlated with IR and triglycerides, whereas EATT correlated with HDL-cholesterol. In PCOS women aged 18–29 years, the cutoff values of CAP and EATT for VAT were 198.0 and 3.07, respectively, with CAP demonstrating higher AUC. In PCOS women aged 30–39 years, the cutoff values were 209.5 and 3.36, respectively, with EATT showing higher AUC. Conclusion: VAT correlates with more metabolic parameters in PCOS than TE-CAP or EATT. TE-CAP is useful for VAT screening in PCOS patients aged 18–39 years, whereas EATT is effective and outperforms CAP in those aged 30–39 years.

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Visceral adipose tissue quality was associated with nonalcoholic fatty liver disease, independent of its quantity

Cited by 6 publications

References 23 publications

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

Quantification of lumbar vertebral fat deposition: Correlation with menopausal status, non-alcoholic fatty liver disease and subcutaneous adipose tissue

Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review

Visceral Adipose Tissue, Epicardial Fat, and Hepatic Steatosis in Polycystic Ovary Syndrome: A Study of Ectopic Fat Stores and Metabolic Dysfunction

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