Visceral adiposity index as a predictor of <scp>NAFLD</scp>: A prospective study with 4‐year follow‐up

Xu, Chaonan; Ma, Zufu; Wang, Yunfeng; Liu, Xiangtong; Tao, Lixin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua

doi:10.1111/liv.13941

Cited by 42 publications

(33 citation statements)

References 27 publications

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“…Proinflammatory cytokines and chemokines produced by infiltrated macrophages could exacerbate IR and recruit more immune cells to the inflamed adipocytes [61]. It was reported in NAFLD patients that liver necroinflammation and fibrosis increased significantly with visceral fat in a dose-dependent manner [62]. Meanwhile, the adipose tissue from NAFLD patients were found with an increased expression of genes that regulate inflammation, and the adipose tissue macrophages produced increased levels of inflammatory cytokines, compared with control [63].…”

Section: Adipose Tissue and Nafldmentioning

confidence: 99%

Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease

Wang

2020

Cell Biosci

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Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver disease worldwide and the anticipated health burden is huge. There are limited therapeutic approaches for NAFLD now. It’s imperative to get a better understanding of the disease pathogenesis if new treatments are to be discovered. As the hepatic manifestation of metabolic syndrome, this disease involves complex interactions between different organs and regulatory pathways. It’s increasingly clear that brain, gut and adipose tissue all contribute to NAFLD pathogenesis and development, in view of their roles in energy homeostasis. In the present review, we try to summarize currently available data regarding NAFLD pathogenesis and to lay a particular emphasis on the inter-organ crosstalk evidence.

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Section: Adipose Tissue and Nafldmentioning

confidence: 99%

Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease

Wang

2020

Cell Biosci

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“…This cohort was built using data from the Health Management Cohort (BHMC). The BHMC is a large-scale longitudinal cohort study that investigates the development of metabolic disorders in healthy individuals from urban areas of Beijing [8,9]. There were 11,585 participants who were recruited to undergo a physical examination in 2012.…”

Section: Study Populationmentioning

confidence: 99%

Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study

Kang

et al. 2020

J Transl Med

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Background: It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of nonalcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are associated with the risk of new-onset NAFLD. Methods:We explored the relationship between SUA trajectories and NAFLD in a cohort including 3822 participants. Individual's SUA trajectories from 2012 to 2014 were defined using group-based trajectory modeling analysis in four distinct patterns: trajectory 1 (n = 991, 25.93%), trajectory 2 (n = 1421, 37.18%), trajectory 3 (n = 1156, 30.22%), and trajectory 4 (n = 254, 6.67%). The logistic regression model was used to evaluate the association between SUA changing trajectories and subsequent NAFLD until 2016. Dose-response relationship between SUA changing trajectories and NAFLD risk was evaluated through the testing of trajectory groups as a continuous variable. Results:The 2-year incidence of NAFLD was 13.27%. Compared with trajectory 1, the adjusted odds risk for NAFLD development was in a dose-response relationship as follows: 1.27 (95% CI 0.91-1.78) for trajectory 2, 1.89 (95% CI 1.29-2.75) for trajectory 3, and 2.34 (95% CI 1.43-3.83) for trajectory 4. And this dose-response relationship was not affected by age, sex, and abdominal obesity. Conclusions:Higher SUA changing trajectory is a risk factor for NAFLD. This finding highlights the importance of paying attention to SUA changing trajectory on the detection and prevention of NAFLD.

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“…There were substantial researches exploring the associations of VAI with chronic diseases in human, which proved that VAI was negatively associated with insulin sensitivity [16,17] and identified as a powerful indicator for pre-diabetes or diabetes [18][19][20], and positively associated with the risk of hyperuricemia [21] and nonalcoholic fatty liver disease (NAFLD) [22]. Additionally, the results of several epidemiological studies [9,15,23] exploring the association between visceral adiposity and risk of hypertension showed that VAI was positively associated with the risk of hypertension in Chinese adult population [9] or Japanese Americans [24], and baseline scores of VAI could predict hypertension and CVD incident in prehypertension or healthy population [15,23], whereas others reported no association [25] or an association in women but not men [26].…”

Section: Introductionmentioning

confidence: 99%

The Visceral Adipose Index in Relation to Incidence of Hypertension in Chinese Adults: China Health and Nutrition Survey (CHNS)

Xue

Dai

et al. 2020

Nutrients

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Hypertension is the most crucial single contributor to global burden of disease and mortality, while weight loss as a non-pharmacological strategy is recommended to reduce blood pressure. This study aims to examine the association between visceral adipose index (VAI) and hypertension in Chinese adults. Data were collected from the China Health and Nutrition Survey (CHNS), consisting of 8374 apparently healthy participants aged ≥18 years in the 2009 CHNS for cross-sectional analysis, and 4275 participants at entry from 2009 to 2011 for cohort analysis. Height, weight, waist circumference, blood pressure (BP), and blood lipid were measured. Information of population characteristics, smoking status, alcohol consumption, physical activity, and diet were determined by validated questionnaire. Higher VAI scores were significantly associated with higher BP levels and higher risk of hypertension after adjustment with potential confounders (all p-trend < 0.001). The adjusted hazard ratio of hypertension was 1.526 (95%CI: 1.194, 1.952; p-trend < 0.01) for participants in the highest quartile of VAI scores when compared with those in the lowest quartile after adjustment for age, physical activity, antihypertensive medication, total energy intake, salt intake, and other major lifestyle factors. VAI scores were significantly, longitudinally associated with hypertension development among apparently healthy Chinese adults.

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Visceral adiposity index as a predictor of NAFLD: A prospective study with 4‐year follow‐up

Abstract: Our findings suggest that the VAI level is an independent risk factor of NAFLD and there is a dose-response relationship between VAI level and NAFLD risk.

Cited by 42 publications

References 27 publications

Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease

Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease

Changing trajectories of serum uric acid and risk of non-alcoholic fatty liver disease: a prospective cohort study

The Visceral Adipose Index in Relation to Incidence of Hypertension in Chinese Adults: China Health and Nutrition Survey (CHNS)

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