Visceral Adiposity Is an Independent Predictor of Incident Hypertension in Japanese Americans

Hayashi, Tomoshige; Boyko, Edward J.; Leonetti, Donna L.; McNeely, Marguerite J.; Newell‐Morris, Laura; Kahn, Steven E.; Fujimoto, Wilfred Y.

doi:10.7326/0003-4819-140-12-200406150-00008

Cited by 248 publications

(206 citation statements)

References 36 publications

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“…Indeed, independent of subcutaneous fat, visceral fat is a strong predictor of dyslipidemia (20,21), glucose tolerance (22,23), insulin resistance (24) and systemic inflammation (25), as well as incidence of hypertension (26), CVD (7), type 2 diabetes (27) and all-cause mortality (28). These observations underscore the notion that both WC and visceral fat should be primary targets for strategies designed to reduce obesity and related CVD risk.…”

Section: Wc Visceral Obesity and Cardiometabolic Riskmentioning

confidence: 97%

Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?

Ross

Janiszewski

2008

Canadian Journal of Cardiology

101

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Section: Wc Visceral Obesity and Cardiometabolic Riskmentioning

confidence: 97%

Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?

Ross

Janiszewski

2008

Canadian Journal of Cardiology

101

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“…Abdominal adiposity is associated with numerous health risk in the pediatric (Bacha et al, 2003;Weiss et al, 2003) and adult populations (Ross et al, 2002;Hayashi et al, 2004). In adults, emerging evidence suggests that cardiorespiratory fitness (CRF) is associated with lower visceral and abdominal subcutaneous adipose tissue (AT) Janssen et al, 2004) independent of body mass index (BMI).…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory fitness and abdominal adiposity in youth

Lee

Arslanian

2006

Eur J Clin Nutr

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The purpose of this study was to determine whether cardiorespiratory fitness (CRF) is associated with lower abdominal adiposity in youth. Subjects included healthy 61 African-American and 52 white children and adolescents (age: 8-17 years). Body composition was measured by dual-energy X-ray absorptiometry and computed tomography. CRF (VO 2max ) was assessed using a graded maximal treadmill test. CRF was inversely related (Po0.05) to total adiposity, waist circumference, and visceral and abdominal subcutaneous adipose tissue (AT) independent of race. These findings remained significant (Po0.05) after adjusting for age, gender and pubertal status. Multiple regression analyses revealed that CRF is an independent contributor (Po0.05) of waist circumference, and visceral and abdominal subcutaneous AT after accounting for age, pubertal status, gender and body mass index percentile. Our observation suggest that in youth, CRF is associated with lower visceral and abdominal subcutaneous AT, and reinforces the notion that youth should engage in regular physical activity to improve aerobic fitness and reduce abdominal adiposity.

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“…One, a link mediated by insulin resistance. [57][58][59] Indeed, adjustment for fasting plasma insulin level by Hayashi et al 60 did not remove a significant relationship between abdominal adiposity and incident hypertension. Two, as endocrine glands, abdominal adipocytes often secret various peptide and nonpeptide compounds such as leptin, angiotensin II, interleukin 6, adiponectin, plasminogen-activator inhibitor, and resistin.…”

Section: Discussionmentioning

confidence: 97%

Regional fat localizations and racial/ethnic variations in odds of hypertension in at-risk American adults

et al. 2006

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The objective of this study was to determine the contribution of regional fat localizations defined as abdominal (AO) or truncal (TO) obesity in racial/ethnic differences to the prevalence odds of hypertension in overweight American adults. Data (n ¼ 5694) from the 1999-2002 US National Health and Nutrition Examination Survey were utilized for this analysis. Abdominal obesity was defined as waist circumference X102 and X88 cm for men and women, respectively. Truncal obesity was defined using ratio of subscapular to triceps skinfold thickness and were X2.24 and X1.32, for men and women, respectively. Prevalence odds ratios from gender-specific logistic regression models were used to evaluate the contribution of regional fat localizations to racial/ethnic variation in hypertension. Statistical adjustment was made for age, education, alcohol intake and body mass index. In both men and women, coexistence of AO and TO was associated with much higher prevalence odds of hypertension than association due to each of the regional fat localizations. In men, coexistence of AO and TO was associated with 1.99, 2.47 and 2.10 increased prevalence odds of hypertension in Whites, Blacks and Mexican Americans, respectively. The corresponding values in women were 2.83, 4.07 and 3.61 in Whites, Blacks and Mexican Americans, respectively. The coexistence of AO and TO appears to be the culprit that contributes to high blood pressure on top of body mass index. Weight reduction programs that are targeted toward abdominal and truncal regions in at-risk populations and along racial/ethnic lines may help to alleviate racial/ethnic disparity in risk of hypertension.

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Visceral Adiposity Is an Independent Predictor of Incident Hypertension in Japanese Americans

Abstract: Greater visceral adiposity increases the risk for hypertension in Japanese Americans.

Cited by 248 publications

References 36 publications

Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?

Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?

Cardiorespiratory fitness and abdominal adiposity in youth

Regional fat localizations and racial/ethnic variations in odds of hypertension in at-risk American adults

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