Visceral/epicardial adiposity in nonobese and apparently healthy young adults: Association with the cardiometabolic profile

Larochellière, Elianne De; Côté, Johanne; Gilbert, Guillaume; Bibeau, Karine; Ross, Marie‐Kristelle; Dion-Roy, V.; Pîbarot, Philippe; Després, Jean‐Pierre; Larose, Éric

doi:10.1016/j.atherosclerosis.2014.01.053

Cited by 47 publications

(48 citation statements)

References 36 publications

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“…In addition, a cross-sectional study in French Canadian young adults found that MRI-measured visceral adipose tissue had a positive and stronger association with markers of cardiovascular health, including systolic and diastolic blood pressures, than other adipose depots. 28 …”

Section: Discussionmentioning

confidence: 99%

Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans

et al. 2015

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In Japanese Americans, intra-abdominal fat area measured by computed tomography is positively associated with the prevalence and incidence of hypertension. Evidence in other populations suggests that other fat areas may be protective. We sought to determine whether a change in specific fat depots predicts the development of hypertension. We prospectively followed 286 subjects (mean age 49.5 yrs, 50.4% male) from the Japanese American Community Diabetes Study for 10 years. At baseline subjects did not have hypertension (defined as blood pressure ≥140/90 mmHg) and were not taking blood pressure or glucose-lowering medications. Mid-thigh subcutaneous fat area, abdominal subcutaneous fat area, and intra-abdominal fat area were directly measured by computed tomography at baseline and 5 years. Logistic regression was used to estimate odds of incident hypertension over 10 years in relation to a 5-year change in fat area. The relative odds of developing hypertension for a 5-year increase in intra-abdominal fat was 1.74 (95% CI 1.28–2.37), after adjusting for age, sex, BMI, baseline intra-abdominal fat, alcohol use, smoking status and weekly exercise energy expenditure. This relationship remained significant when adjusted for baseline fasting insulin and 2-hour glucose levels or for diabetes and prediabetes classification. There were no significant associations between baseline and change in thigh or abdominal subcutaneous fat areas and incident hypertension. In conclusion, in this cohort of Japanese Americans, the risk of developing hypertension is related to the accumulation of intra-abdominal fat rather than the accrual of subcutaneous fat in either the thigh or abdominal areas.

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Section: Discussionmentioning

confidence: 99%

Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans

et al. 2015

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“…32,[46][47][48] Epicardial fat has also been linked to an increased systemic inflammatory status in type 2 diabetes patients with acute myocardial infarction, and in patients with a higher EAT thickness it was associated with an enhanced left ventricular remodeling process and lower ejection fraction at six months. 49 Further studies are needed to elucidate the effect of a reduction of EAT on risk diminution, although some researchers have proved that the regression of EF can be achieved with weight loss measures, dietary modifications, regular physical exercise, and lipid-lowering therapies with statins and ezetimibe.…”

Section: Discussionmentioning

confidence: 99%

Original research. The Assessment of Epicardial Adipose Tissue in Acute Coronary Syndrome Patients. A Systematic Review

Benedek

Raț

Hodaş³

et al. 2017

Journal of Cardiovascular Emergencies

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“…According to a recently reported data, even in nonobese and apparently healthy young population, visceral adipose tissue and other regional adipose tissue such as epicardial adipose tissue carried significant correlations with all markers of cardiometabolic risk. [21] Accordingly, a 4-year changes in visceral adiposity and the resulting effect on proteinuria development was evaluated with 2393 members of the Korean general population in this study.…”

Section: Discussionmentioning

confidence: 99%

Four-Year Changes in Visceral Fat Mass and the Risk of Developing Proteinuria in the General Population

et al. 2015

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BackgroundPrevious cross-sectional studies demonstrated the close relationship between visceral obesity and the increased prevalence of proteinuria. But, little is known about the role of changes in visceral fat mass (∆VFM) over several years in the development of proteinuria. In this longitudinal cohort study with the general population, the changes in ∆VFM as well as baseline VFM on proteinuria development were evaluated.MethodsHealthy individuals (n = 2393) who participated in two health screening exams were analyzed. Subjects were divided into three groups based on gender-specific tertiles of baseline VFM and ∆VFM. Each patient was tested for proteinuria using a dipstick, and proteinuria was defined as 1+ or greater.ResultsThe mean age was 51.9±7.7 years, and the incidence of proteinuria was 3.9% (n = 93). During the 4 years, 52.5% of the subjects experienced a decline in ∆VFM. However, subjects who developed proteinuria exhibited a significant increase in ∆VFM. Even after adjustment for age, smoking, systolic and diastolic BP, serum creatinine, and hs-CRP levels, the highest tertiles for baseline VFM [men, odds ratio (OR) 3.43, 95% confidence interval (CI) 1.22–9.67; women, OR 2.01, 95% CI 1.05–4.15] and ∆VFM (men, OR 2.92, 95% CI 1.22–6.99; women, OR 3.16, 95% CI 1.56–6.39) were independent predictors of proteinuria development. Following adjustment of both parameters, subjects in the highest baseline VFM and ∆VFM tertiles exhibited the greatest risk of proteinuria development, which suggested the additive harmful effects of the two factors.ConclusionsBaseline VFM and greater increase in ∆VFM were both important risk factors for developing proteinuria in the general population. Appropriate education and interventions to prevent accumulation of VFM should be the major focus of preemptive strategies.

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Visceral/epicardial adiposity in nonobese and apparently healthy young adults: Association with the cardiometabolic profile

Cited by 47 publications

References 36 publications

Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans

Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese Americans

Original research. The Assessment of Epicardial Adipose Tissue in Acute Coronary Syndrome Patients. A Systematic Review

Four-Year Changes in Visceral Fat Mass and the Risk of Developing Proteinuria in the General Population

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