Visceral fat accumulation and metabolic syndrome in children: the impact of <scp>T</scp>rp64<scp>A</scp>rg polymorphism of the beta3‐adrenergic receptor gene

Oguri, Kazuta; Tachi, Toshiki; Matsuoka, Takeshi

doi:10.1111/apa.12149

Cited by 12 publications

(13 citation statements)

References 28 publications

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“…This inversion explains ∼40% of the population-attributable risk for joint susceptibility to obesity and asthma. Additional genes including the β2-adrenergic receptor gene (ADRB2), 148,149 the TNF gene, 150,151 and the lymphotoxin-α (LTA) gene 152,153 have been associated in both obesity and asthma in children. However, the limited number of these studies highlights the paucity of data on genetic susceptibility for obesity-related asthma.…”

Section: Genetics Of Obesity-related Asthmamentioning

confidence: 99%

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

2016

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The burden of obesity-related asthma among children, particularly among ethnic minorities, necessitates an improved understanding of the underlying disease mechanisms. Although obesity is an independent risk factor for asthma, not all obese children develop asthma. Several recent studies have elucidated mechanisms, including the role of diet, sedentary lifestyle, mechanical fat load, and adiposity-mediated inflammation that may underlie the obese asthma pathophysiology. Here, we review these recent studies and emerging scientific evidence that suggest metabolic dysregulation may play a role in pediatric obesity-related asthma. We also review the genetic and epigenetic factors that may underlie susceptibility to metabolic dysregulation and associated pulmonary morbidity among children. Lastly, we identify knowledge gaps that need further exploration to better define pathways that will allow development of primary preventive strategies for obesity-related asthma in children.

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Section: Genetics Of Obesity-related Asthmamentioning

confidence: 99%

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

2016

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“…Unfortunately, a number of factors make intervention studies difficult to compare: differences in dietary changes (caused both by recommendations and patient compliance); the intensity and frequency of physical activity; the pre-selection of participants; and the relatively low number of individuals included (often less than 100 participants). Therefore, it is not surprising that most of the studies published to date have recorded inconclusive results and are difficult to replicate (8)(9)(10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Suchánek¹,

Lánská²,

Hubáček³

2015

Cent Eur J Public Health

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“…In the coding region of this AR subtype a common missense mutation resulting in the substitution of arginine for tryptophan at codon 64 (Trp64Arg) has been reported to be significantly associated with whole body obesity, visceral fat accumulation and other metabolic syndrome components or their cluster [54][55][56][57]. Unfortunately, as previously observed in adults' studies, the association between Trp64Arg and BP levels in obese children was found significant in some studies [54,58] and not significant in others [51,53]. The inconsistencies between these different children's populations have led some investigators to conclude that the Trp64Arg variant plays a small role in human obesity and its related conditions such as hypertension [53].…”

Section: α-And β-Adrenergic Receptors (Adra and Adrb) Genesmentioning

confidence: 98%

Searching for genes involved in hypertension development in special populations: children and pre-eclamptic women. Where are we standing now?

Danese¹,

Montagnana²,

Fava³

2013

Clinical Chemistry and Laboratory Medicine (CCLM)

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Primary hypertension is a very common disorder particularly in the aging population but hypertensive disorders can appear earlier in life, especially when obesity and unhealthy lifestyle are present. Also pregnant women can be at risk of developing gestational hypertension and/or pre-eclampsia, which causes complications in nearly 7% of pregnancies. These "special" populations could be regarded as natural models suited to reveal mechanisms of hypertension development which are either common to other forms of hypertension, including primary hypertension or specific to these populations. Recent studies in the field of genetics of primary hypertension have used new powerful tools, such as genome-wide association studies (GWAS) and sequencing, but studies about hypertension during childhood and in pregnancy have seldom used high-throughput technologies and the knowledge in this field comes mostly from the candidate gene approach. In this review we summarize some interesting results from genetic studies conducted in childhood and adolescence and during pregnancy and underline the need to apply modern technologies in these potentially very fruitful populations.

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Visceral fat accumulation and metabolic syndrome in children: the impact of Trp64Arg polymorphism of the beta3‐adrenergic receptor gene

Abstract: Trp64Arg polymorphism of the ADRB3 gene may affect VF accumulation and be associated with MS, a cluster of conditions involving aggravated lipid metabolism and higher blood pressure, in Japanese children.

Cited by 12 publications

References 28 publications

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

Pediatric Obesity-Related Asthma: The Role of Metabolic Dysregulation

Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Searching for genes involved in hypertension development in special populations: children and pre-eclamptic women. Where are we standing now?

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