Visceral fat and total body fat mass correlate differently with hormones in rat

Ebal, E.; Cavalié, H.; Michaux, O.; Lac, G.

doi:10.1016/j.patbio.2007.09.002

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…In turn, some state that higher FM during infancy may track to adulthood [27] and has been associated with an increased risk of metabolic and cardiovascular consequences in adult life [28,29,30]. However, controversy exists whether leptin is secreted preferentially by subcutaneous adipocytes or by visceral adipocytes and how this relates to the risk of accumulation of FM with adverse metabolic consequences [31,32]. …”

Section: Discussionmentioning

confidence: 99%

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Poelje

Lagemaat²,

Lafeber³

et al. 2014

Horm Res Paediatr

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Background/Aims: In term subjects, fat mass (FM) is positively associated with leptin, whereas studies in preterm infants show conflicting results. However, none of these studies measured FM by dual-energy X-ray absorptiometry (DEXA). This study aims to relate FM measured by DEXA in relation to leptin and growth in preterm infants. Methods: In 139 preterm infants, weight (kg) and length (cm) were measured at birth, term age, and 6 months' corrected age (CA). FM (kg), measured by whole-body DEXA, and leptin (µg/l) were measured at term age and 6 months' CA. Results: At term age and 6 months' CA, FM was associated with leptin (β = 1.94, 95% CI: 1.51-2.36, and β = 0.37, 95% CI: 0.26-0.48, respectively; p < 0.001). Gain in weight standard deviation score (SDS) between term age and 6 months' CA was associated with FM and leptin at 6 months' CA (β = 0.24, 95% CI: 0.18-0.30, and β = 0.25, 95% CI: 0.16-0.33, respectively; p < 0.001). Conclusion: In preterm infants, FM measured by DEXA is associated with leptin, which indicates that leptin is a marker of body FM during the first 6 months after term age. Gain in weight SDS between term age and 6 months' CA results in higher FM and higher leptin at 6 months' CA.

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Section: Discussionmentioning

confidence: 99%

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Poelje

Lagemaat²,

Lafeber³

et al. 2014

Horm Res Paediatr

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“…Although rates of body weight gain tended to decrease after 56 days and beyond (Figure 1) in mice fed the purified ACNs and a high-fat diet, serum leptin was not altered in that treatment group. It is not clear whether the decreases in leptin observed with purified ACN treatments are merely a result of decreased fat mass, because leptin is secreted by adipose tissue and levels are proportional to the amount of total adipose tissue mass as well as perirenal fat mass (22) or whether the ACNs have an effect on adipose tissue cells to decrease the production of leptin in the cell. In one study (17), the ratio of leptin to adipose tissue mass, as reflected in the epididymal plus retroperitoneal fat, was decreased in the mice consuming purified blueberry ACNs, which was true whether they were fed a LF or HF diet.…”

Section: Discussionmentioning

confidence: 99%

Dietary Black Raspberry Anthocyanins Do Not Alter Development of Obesity in Mice Fed an Obesogenic High-Fat Diet

Prior

Wilkes

Rogers

et al. 2010

J. Agric. Food Chem.

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Anthocyanins (ACNs) from various foods have been shown to minimize the development of obesity in some animal models. The objective of the current study was to compare the effects of feeding purified black raspberry (BRB) ACNs or the freeze-dried whole BRB on the development of obesity. Male C57BL/6J mice (25 days of age) were assigned at random to treatments (7/treatment; 3/cage). The treatments included (1) control low-fat diet (10% calories from fat) (LF); (2) LF plus BRB juice in place of drinking water; (3) LF diet plus purified BRB ACNs in drinking water (1.25 mg/mL); (4) control high-fat diet (60% calories from fat) (HF60); (5) HF60 diet + BRB juice in place of drinking water; (6) HF60 diet + ACNs in drinking water (1.25 mg/mL); and (7) HF60 + freeze-dried whole BRB powder (21.7 g/kg of diet). Body weight gains in mice fed HF60 diet plus purified BRB ACNs tended to be lower after 56, 63, and 70 days than in mice fed HF60 alone. Body weights were increased at time of sacrifice, but heart, liver, and kidney weights as a percentage of body weight were decreased in mice fed HF60 diet compared to LF fed mice. Weights (g or g/body weight) of epididymal and retroperitoneal fat were increased in the HF60 fed mice compared to LF fed mice. Fasting serum glucose, leptin, and insulin levels as well as homeostasis assessment of insulin resistance (HOMA-IR) were elevated in mice fed the HF60 diet relative to LF-fed controls. Serum cholesterol, triglycerides, and monocyte chemoattractant protein-1 (MCP-1) were not altered by diet. Serum levels of resistin were increased in mice fed the HF60 diet compared to mice fed the LF diet. None of the responses measured were altered by whole BRB powder included in the diet relative to the HF60 control diet. Cyanidin containing di- or triglycosides in BRB was ineffective in altering the development of obesity in contrast to cyanidin-monoglycosides, which have been shown to be effective. The sugar moiety on the anthocyanidins may be an important factor in determining the response in the development of obesity.

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“…Thus, rats submitted to CMS showed an increased HOMA index, which is an insulin resistance index. Indeed, the insulin resistance observed in stressed rats fed with hypercaloric diet may be associated to increased adiposity (Ebal et al, 2008). This finding corroborate with Wagenknecht et al (2003) who reported that hepatic insulin resistance is strongly linked to abdominal fat pad.…”

Section: Sd Cms Hd Hd+cmssupporting

confidence: 85%

Efeito do estresse cronico e de dieta hipercalorica sobre o peso corporal e metabolismo de ratos

Ferreira¹,

Marcondes²

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Aos meus queridos pais, Maria e Manoel pelo seu amor, pelo seu apoio, por acreditarem sempre em mim e por terem me ensinado valiosos princípios de vida.Aos amados irmãos Reginaldo, Fernando, João Paulo e Debora, e cunhadas Daniele e Morgana, pelo apoio em todos os momentos de minha vida e por me mostrarem que distância pode separar irmãos, mas não é capaz de quebrar os laços de amor, carinho e amizade existentes.Ao meu amado e lindo sobrinho Fernando.Ao Gian pelo seu amor e todo companheirismo nos meus momentos mais difíceis e por sempre vibrar comigo nos momentos de conquistas e alegria.Às amigas, Claudia Irene, Karla, Luana, Nadia e Mariana simplesmente pela amizade sincera e verdadeira. viii grupo controle. O grupo AP, mas não o grupo ECMI, apresentou redução nas gorduras mesentérica (41%), inguinal (28%) e perirrenal (40%), menor proporção gordura total/peso corporal final (0,02±0,001 vs. 0,03±0,001) e menor porcentagem de gordura na carcaça (3,39±0,44 vs. 6,29±0,51%) comparado ao controle, sem diferença entre controle e ECMI. O efeito redutor do ECMI sobre o peso corporal não pode ser totalmente explicado pela restrição alimentar durante o estresse. A longo prazo, o ECMI e o tratamento com dieta hipercalórica têm efeitos semelhantes sobre a dislipidemia em ratos.Tais efeitos são potencializados quando combinados. O efeito redutor no peso corporal, promovido pelo ECMI, sofre influência da dieta empregada, e é revertido após o estresse.

show abstract

Visceral fat and total body fat mass correlate differently with hormones in rat

Cited by 5 publications

References 18 publications

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Relationship between Fat Mass Measured by Dual-Energy X-Ray Absorptiometry and Leptin in Preterm Infants between Term Age and 6 Months' Corrected Age

Dietary Black Raspberry Anthocyanins Do Not Alter Development of Obesity in Mice Fed an Obesogenic High-Fat Diet

Efeito do estresse cronico e de dieta hipercalorica sobre o peso corporal e metabolismo de ratos

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