Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients

Lü, Qian; Cheng, Lei; Wang, Tao; Wan, Jie; Liao, Lan-Lan; Zeng, Jing; Qin, Chao; Li, Keji

doi:10.1053/j.jrn.2008.05.006

Cited by 50 publications

(41 citation statements)

References 54 publications

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“…In HD patients, abdominal fat deposition has been linked to inflammation and subsequent increases in mortality risk [33]. In PD patients, visceral fat level was an independent predictor of pulse wave velocity and brachial artery flow–mediated dilatation, and was also one of the risk factors for cardiovascular disease in this population [34]. Our previous study also revealed that larger amounts of adipose tissue were associated with higher serum levels of pro-inflammatory markers and were, therefore, related to the left ventricular diastolic dysfunction [35].…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients

Huang

Yang

et al. 2013

Cardiovasc Diabetol

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BackgroundIn the general population, metabolic syndrome (MetS) is correlated with visceral fat and a risk factor for cardiovascular disease (CVD); however, little is known about the significance of abdominal fat and its association with inflammation and medication use in peritoneal dialysis (PD) patients. We investigated the relationship of visceral fat area (VFA) with C-reactive protein (CRP) levels and medication use in PD patients and followed their clinical outcomes.MethodsIn a prospective study from February 2009 to February 2012, we assessed diabetes mellitus (DM) status, clinical and PD-associated characteristics, medication use, CRP levels, components of MetS, and VFA in 183 PD patients. These patients were categorized into 3 groups based on MetS and DM status: non-MetS (group 1, n = 73), MetS (group 2, n = 65), and DM (group 3, n = 45). VFA was evaluated by computed tomography (CT) and corrected for body mass index (BMI).ResultsPatients in group 1 had smaller VFAs than patients in groups 2 and 3 (3.2 ± 1.8, 4.6 ± 1.9, and 4.9 ± 2.0 cm2/[kg/m2], respectively, P < 0.05) and lower CRP levels (0.97 ± 2.31, 1.27 ± 2.57, and 1.11 ± 1.35 mg/dL, respectively, P < 0.05). VFA increased with the number of criteria met for MetS. After adjusting for age, body weight, and sex, CRP and albumin levels functioned as independent positive predictors of VFA; on other hand, the use of renin-angiotensin system blockers was inversely correlated with VFA in PD patients without DM. In the survival analysis, DM patients (group 3) had the poorest survival among the 3 groups, but no significant differences were found between groups 1 and 2.ConclusionThis study showed that VFA and MetS are associated with CRP levels but cannot predict survival in PD patients without DM. The complex relationship of nutritional parameters to VFA and MetS may explain these results. The type of antihypertensive medication used was also associated with the VFA. The mechanisms behind these findings warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients

Huang

Yang

et al. 2013

Cardiovasc Diabetol

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“…Since this device uses multiple frequencies (5, 50, 250 and 500 kHz) for analysis, it measures body composition with higher precision than other traditional devices using BIA. This method has been used in many studies in a range of women from children to adults , and a strong correlation has been reported between impedance and body composition values measured with dual‐energy X‐ray absorptiometry (DXA) . Furthermore, muscle mass as measured with this device, included skeletal and smooth muscle body water content: the measured value was tissue mass (composed of body weight) minus fat and bone mineral content.…”

Section: Methodsmentioning

confidence: 99%

Changes in neutrophil functions during a 10‐month soccer season and their effects on the physical condition of professional Japanese soccer players

et al. 2012

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We examined changes in neutrophil function of soccer players over a 10-month period and determined its effectiveness as an index for athlete physical condition. Subjects included 21 male professional Japanese soccer players. Data on body composition, myogenic enzymes and neutrophil function were obtained before and after 2 h of training at 3 investigation points: one week before opening season, at season mid-point, and one week before the last game of the season. As a result, change ratios of myogenic enzyme levels before and after the 2-hr training session at the third investigation point were significantly higher compared to the two other points. Reactive oxygen species production and phagocytic activity significantly increased after 2-hr training session at point 1, although the extent of the increase became smaller over time and ROS production capability decreased significantly by point 3 assessment. Fatigue, especially muscle fatigue, chronically accumulated along with a gradual decrease in neutrophil immune function over the 10-month season. Therefore, determination of neutrophil function can be used as a useful index to assess and understand an athlete's physical condition.

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“…Substantial evidence has accumulated indicating that arterial stiffness and increased baPWV are important independent predictors of CVD events (Laurent et al 2006). The amount of visceral fat is an independent predictor of PWV, and could be considered a risk factor for CVD (Lu et al 2008). Our recent study shows that the age-related increase baPWV is attenuated in men trained to row, who retained lean soft tissue mass as measured by DXA (Sanada et al 2009b).…”

Section: Relationship Between Sarcopenia and Cvd Risk Factorsmentioning

confidence: 99%

A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors

et al. 2010

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In this study of Japanese men and women, we determine reference values for sarcopenia and test the hypothesis that sarcopenia is associated with risk factors for cardiovascular disease, independent of waist circumference. A total of 1,488 Japanese men and women aged 18-85 years participated in this study. Appendicular muscle mass (AMM) was measured by dual-energy X-ray absorptiometry. Reference values for classes 1 and 2 sarcopenia (skeletal muscle index: AMM/height2, kg m-2) in each sex were defined as values one and two standard deviations below the sex-specific means of reference values obtained in this study from young adults aged 18-40 years. The reference values for class 1 and class 2 sarcopenia were 7.77 and 6.87 kg m-2 in men and 6.12 and 5.46 kg m-2 in women. In subjects both with class 1 and class 2 sarcopenia, body mass index and % body fat were significantly lower than in normal subjects. Despite whole-blood glycohaemoglobin A1c in men with class 1 sarcopenia was significantly higher than in normal subjects, and brachial-ankle pulse wave velocity in women both with class 1 and class 2 sarcopenia were significantly higher than in normal subjects, using one-way ANCOVA with adjustment for the covariate of waist circumference. Although sarcopenia is associated with thin body mass, it is associated with more glycation of serum proteins in men and with greater arterial stiffness in women, independent of waist circumference.

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Visceral Fat, Arterial Stiffness, and Endothelial Function in Peritoneal Dialysis Patients

Cited by 50 publications

References 54 publications

Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients

Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients

Changes in neutrophil functions during a 10‐month soccer season and their effects on the physical condition of professional Japanese soccer players

A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors

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