Visceral Injury and Systemic Inflammation in Patients Undergoing Extracorporeal Circulation During Aortic Surgery

Abstract

This study shows the development of intestinal mucosal injury during ECC with DAP or DAP and SP, indicative of insufficient intestinal perfusion. Intestinal injury was associated with a systemic pro-inflammatory response.

The role of serum intestinal fatty acid binding protein levels and D-lactate levels in the diagnosis of acute intestinal ischemia

“…Kanda T et al [17] also found that the serum I-FABP level increased in the presence of not only ischemic disease but also other small bowel disease. Hansen et al [18] reported that the blood I-FABP levels rose in patients with small bowel injury associated with extracorporeal circulation and that there was a strong correlation between such small bowel injury and the onset of the systemic inflammatory response syndrome. Guthmann et al [19] reported an elevation of serum I-FABP in children with necrotizing enterocolitis, and Wiercinska-Ddrapalo et al reported a similar elevation in patients with ulcerative colitis [10].…”

Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen: a multicenter, observer-blinded validation study

“…It is also noteworthy that abdominal surgery or decompression with a long tube was required in 47 (72.3%) of our present 65 patients with non-ischemic small bowel disease in whom the serum I-FABP level was above the cutoff level. Recently, Hanssen et al [20] reported that the blood I-FABP level rose in patients with small bowel injury associated with extracorporeal circulation and that there was a strong correlation between such small bowel injury and the onset of the systemic inflammatory response syndrome. These findings suggest that I-FABP is released into the blood by injury of the small bowel epithelium, regardless of the type of injury, and that the elevation of serum I-FABP in non-ischemic diseases may reflect the extent and seriousness of morbidity.…”

Sarcopenia is associated with an increased inflammatory response to surgery in colorectal cancer

“…Moreover, IL-6 was the predominant stimulator of most acute-phase proteins [14]. IL-6 concentrations were measured by ELISA as previously described (lower detection limit: 10 pg/mL) [15].…”