Visceral Kaposi's sarcoma with intracranial metastasis: A rare complication of renal transplantation

Abstract

The incidence of Kaposi's sarcoma (KS) has increased in solid organ transplantation recipients. This type of KS tends to be aggressive, involving lymph nodes, mucosa and visceral organs in about half of patients, sometimes in the absence of skin lesions. Brain involvement of KS has rarely been reported. A 16-yr-old Turkish boy underwent renal transplantation from his mother. The immunosuppressive regimen included prednisolone, cyclosporin A and azathioprine. Fourteen months later the azathioprine was changed to cyclophosphamide (3 mg/kg/day) because of the development of a nephrotic syndrome. After 12 weeks, the cyclophosphamide was changed to mycophenolate mofetil (MMF) to control the nephrotic syndrome. At this time his serum creatinine level rose to 2.1 mg/dL. Polyclonal or monoclonal antibodies were never given. Multiple intra-abdominal lymphadenopathy was detected on abdominal tomography at the 32nd month after renal transplantation. Kaposi's sarcoma was diagnosed via laparotomy and biopsy. He had a generalized tonic and clonic seizure and contrast enhanced cranial tomography showed two intracranial masses which had an abundant vascular component which caused a mild shift. One of the masses was removed via a burr-hole with the aim of diagnosis and treatment of the shift. A pathologic examination of the intracranial lesion was also reported as Kaposi's sarcoma. Herpes virus-8 DNA was detected by PCR in the intracranial lesion.

Kaposi sarcoma of the musculoskeletal system

“…Although we identified several publications in which transplantation recipients presented with widespread and often fatal KS, 42,43 we encountered only 1 such case in which bone involvement by KS was reported (Case 1 in Table 4). In a reported cohort of 542 kidney allograft recipients, 21 patients (4%) had KS, 6 of whom developed visceral KS.…”

Skin Cancers Following Pediatric Organ Transplantation

“…Contrasting with adults, (Table 3). [27][28][29][30][31][32] Among the eight reported cases, most were kidney transplant recipients. The age at KS occurrence varied from 5 to 17 years.…”

Skin cancer in children after organ transplantation

“…It may appear from about 5 months to 17 years after the transplantation but it is most commonly observed several months after the organ transplantation. Similarly to adults, there is a proven link between an infection with HHV 8 and later development of Kaposi's sarcoma [36,37].…”