Viscoelastic properties of polymerlike reverse micelles

Schurtenberger, Peter; Scartazzini, Roger; Luisi, Pier Luigi

doi:10.1007/bf01336804

Cited by 115 publications

(111 citation statements)

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“…The same structural organization has been confirmed for the lecithin organogel with water (6,7,9,36,38). Since the rheological behavior of the glycerol-and water-containing organogels has much in common with each other, this strongly suggests that glycerol induces the similar transformation of spherical micelles into polymer-like ones as water does.…”

Section: Comparison Characteristics Of Water-and Glycerolcontaining Osupporting

confidence: 65%

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Electrorheological Effects in Lecithin Organogels with Water and Glycerol

Shchipunov

Dürrschmidt

Hoffmann

1999

Journal of Colloid and Interface Science

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Section: Comparison Characteristics Of Water-and Glycerolcontaining Osupporting

confidence: 65%

“…The transition from a low-viscous nonaqueous lecithin solution demonstrating Newtonian behavior to a jelly-like one with Maxwell rheology is caused by the addition of small amounts of polar additives (3,36,37). The transparency and optical isotropy of the organogel remain as before.…”

Section: Comparison Characteristics Of Water-and Glycerolcontaining Omentioning

confidence: 90%

Electrorheological Effects in Lecithin Organogels with Water and Glycerol

Shchipunov

Dürrschmidt

Hoffmann

1999

Journal of Colloid and Interface Science

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“…The higher values of [ETA*] obtained using linear alkanes were related to the higher state of structural organization in LOs. 21,22 Similarly, Schurtenberger et al 76 found that increasing the gelator concen-tration leads to an increase in the viscosity and in turn the gel strength of a soy lecithin/IPP organogel matrix.…”

Section: Rheological Behaviormentioning

confidence: 95%

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

2005

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The purpose of this review is to give an insight into the considerable potential of lecithin organogels (LOs) in the applications meant for topical drug delivery. LOs are clear, thermodynamically stable, viscoelastic, and biocompatible jelly-like phases, chiefly composed of hydrated phospholipids and appropriate organic liquid. These systems are currently of interest to the pharmaceutical scientist because of their structural and functional benefits. Several therapeutic agents have been formulated as LOs for their facilitated transport through topical route (for dermal or transdermal effect), with some very encouraging results. The improved topical drug delivery has mainly been attributed to the biphasic drug solubility, the desired drug partitioning, and the modification of skin barrier function by the organogel components. Being thermodynamically stable, LOs are prepared by spontaneous emulsification and therefore possess prolonged shelf life. The utility of this novel matrix as a topical vehicle has further increased owing to its very low skin irritancy potential. Varied aspects of LOs viz formation, composition, phase behavior, and characterization have been elaborated, including a general discussion on the developmental background. Besides a comprehensive update on the topical applications of lecithin organogels, the review also includes a detailed account on the mechanistics of organogelling.

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“…Skin was thawed and placed on a Franz-type diffusion cell (Hanson Research Co., Chatsworth, CA, U.S.A.) with a receptor volume ranging from 7.0 to 7.3 mL and a diffusional area of 1.74 cm 2 . PBS was added to the receptor cell, which was maintained at 32°C.…”

Section: Methodsmentioning

confidence: 99%

“…These reverse worms become tangled in the oil and form a three-dimensional (3D) network throughout the solution, turning the solution into an gel-like solution (also called a lecithin organogel). [1][2][3][4][5][6] In this reverse micellar system the polar substance is the key ingredient for the formation of reverse worms. We have also identified other key ingredients that can be used as substitutes for water in the preparation of reverse worms in n-decane, such as urea, 7) sucrose fatty acid esters, 8) D-ribose, 9) 2-deoxy-D-ribose, 9) polyglycerols, 10) ascorbic acid, 11) and multivalent carboxylic acids.…”

mentioning

confidence: 99%

Skin Permeation of Testosterone from Viscoelastic Lecithin Reverse Wormlike Micellar Solution

Imai

Hashizaki

Yanagi

et al. 2016

Biological & Pharmaceutical Bulletin

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We evaluated testosterone-containing lecithin reverse wormlike micelles (reverse worms) composed of a polar substance/lecithin/isopropyl myristate for transdermal application. Water, D-ribose, or tetraglycerol were used as the polar substance and were key ingredients for forming the reverse worms. Using the reverse worms, 1 wt% of testosterone could be stably solubilized. When using D-ribose as polar substance, the maximum zero-shear viscosity of the reverse worms solution was higher than that of systems using water or tetraglycerol as the polar substance. The mechanism of skin permeation of testosterone from reverse worms solution was elucidated using skin permeation experiments with hairless mouse skin. When the structure of the reverse worms transitioned to lamellar liquid crystals at the skin/formulation interface, testosterone became supersaturated in the formulations. The structural transition occurred in systems using water or D-ribose as the polar substance, increasing the flux of testosterone. The flux of testosterone from reverse worms solution thus depends on the type of polar substance used.Key words reverse wormlike micelle; lecithin organogel; skin permeation; rheology; phase diagram; hairless mouse skin Recent advances in drug dosage forms have led to improved quality of life for patients. The transdermal dosage form, in particular, represents one of the most important drug delivery methods. Transdermal dosage forms enable avoidance of the hepatic first-pass effect, which can be problematic with oral administration. Another advantage of transdermal dosage forms is that they are easy to apply and remove from the skin. Based on these advantages, transdermal dosage forms have been adopted for a variety of medications.We investigated the possibility of using lecithin reverse wormlike micelle (called reverse worms) comprised of a polar substance/lecithin/oil as the vehicle for transdermal therapeutic application of testosterone (TES). Lecithin is an amphiphilic molecule composed of both hydrophilic and hydrophobic groups. In general, lecithin forms spherical or ellipsoidal reverse micelles when added alone to oil. When trace amounts of a polar substance (e.g., water) 1) are added to this solution, the polar substance can attach to the phosphate groups of the lecithin molecules via hydrogen bonding, widening the gap between the head groups of neighboring lecithin molecules. Thus, the value of the critical packing parameter decreases and the interface curvature of the molecular assembly subsequently induces the formation of reverse worms. As a result, phase transition from reverse spherical micelles to reverse worms takes place. These reverse worms become tangled in the oil and form a three-dimensional (3D) network throughout the solution, turning the solution into an gel-like solution (also called a lecithin organogel). [1][2][3][4][5][6] In this reverse micellar system the polar substance is the key ingredient for the formation of reverse worms. We have also identified other key ingredients that can be...

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Viscoelastic properties of polymerlike reverse micelles

Cited by 115 publications

References 20 publications

Electrorheological Effects in Lecithin Organogels with Water and Glycerol

Electrorheological Effects in Lecithin Organogels with Water and Glycerol

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

Skin Permeation of Testosterone from Viscoelastic Lecithin Reverse Wormlike Micellar Solution

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