Visfatin in juvenile obesity – the effect of obesity intervention and sex

Krzystek−Korpacka, Małgorzata; Patryn, Eliza; Bednarz−Misa, Iwona; Hotowy, Katarzyna; Noczyńska, Anna

doi:10.1111/j.1365-2362.2011.02538.x

Cited by 16 publications

(14 citation statements)

References 41 publications

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“…Our results are in line with those reported for other cytokines such as leptin, IL-6 [44], or visfatin [49] in WL intervention studies with obese children from similar age ranges. Although, CT-1 is a protective cytokine, Moreno-Aliaga et al suggested that it could be increased in obesity as a compensatory mechanism to fight against this disease [13].…”

Section: Discussionsupporting

confidence: 92%

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

et al. 2013

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Fax: 0034 948 425619Word count of text (3,301), abstract (250), number of references (50), number of tables (2) and number of figures (2). CONFLICT OF INTEREST:The authors have nothing to disclose. 2 ABSTRACTObjective: Cardiotrophin-1 (CT-1) shares some similarities with other cytokines, and participates in the control of energy metabolism. Higher circulating levels are observed in obese humans, but little information is gathered in weight loss (WL) programs.Therefore, we aimed to investigate the association of serum CT-1 levels with metabolic variables and the risk of developing metabolic syndrome (MetS) after a WL program in overweight/obese children. Subjects and Methods:Forty-four overweight/obese children (mean age 11.5 yr; 50% males) undergoing a 10-week WL program were enrolled. Subjects were dichotomized at the median of Body Mass Index-Standard Deviation Score (BMI-SDS) change, as high and low responders after intervention.Results: CT-1 levels were significantly reduced (-48 fmol/mL, p=0.043) in the high responder group after the WL program. They had significantly lower body weight (-3.7 kg, p<0.001), body fat mass (-8%, p<0.001), BMI-SDS (-0.78, p<0.001) and waist circumference (-5.4 cm, p<0.001), and a significant improvement in lipid and glucose profiles (p<0.05). Interestingly, decreased CT-1 levels significantly predicted changes in total cholesterol (41%) and LDL-cholesterol (28%). Moreover, in our participants the lower the CT-1 levels, the higher the reduction in MetS risk components, after the 10-week intervention, (p-ANCOVA=0.040, p-trend=0.024). Conclusion:We showed, for the first time, a reduction in serum CT-1 levels after a WL program and this decrease in CT-1 was strongly associated with a reduction in cholesterol levels and in MetS risk factors in overweight/obese children. Our findings may suggest that CT-1 could be an indirect marker for the diagnosis of MetS in this population.

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Section: Discussionsupporting

confidence: 92%

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

et al. 2013

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“…The NAMPT is an enzyme that triggers the synthesis of nicotinamide adenine dinucleotide (NAD), which is essential for the functioning of cells β-pancreaticin insulin secretion [2]. As in both cases visfatin may promote reduction of blood glucose, a negative association is suggested between visfatin and insulin resistance [53,54], as observed in our results.…”

Section: Discussionsupporting

confidence: 73%

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Simões

Domingos

Oliveira

et al. 2018

Nutrire

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Background: The evidence that cardiovascular disease begins in childhood and adolescence, especially in the presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk, and insulin resistance with concentrations of resistin and visfatin, in children. Methods: A cross-sectional study was developed with 178 children of 6-10 years old enrolled in public city schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and visfatin with variables of interest. Results: In healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waistto-height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was negatively associated with the HOMA-IR index. Conclusions: Our study shows an association between anthropometric and biochemical variables related to visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In addition, both adipokines are strongly related to central obesity, in children.

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“…This result was in agreement with a Turkish study that reported plasma visfatin levels of 4.0 (SD 3.0) ng/mL in the obese group and 2.2 (SD 1.5) ng/mL in the non-obese group (p=0.014). 9 Similar results were also found by Araki et al in Japan, 33 plasma visfatin levels in obese children were found to be increased two-fold compared to children with normal BMI. 12 Visfatin is produced by macrophages in fat tissue, especially visceral fat tissue.…”

Section: Discussionsupporting

confidence: 79%

Visfatin levels in non-obese, obese, and insulin resistant adolescents

Ihsan

Rini

Yaswir

2017

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Background preterm infants are vulnerable to iron deficiency (ID) Background Adipose tissue is not merely a site for energy storage, but is also the largest endocrine organ, secreting various adipocytokines. plasma visfatin, an adipocytokine predominantly secreted from visceral adipose tissue, has insulin-mimetic effects, and has been closely linked to insulin resistance. Objective To compare plasma visfatin levels between obese and non-obese adolescents, as well as between obese adolecents with and without insulin resistance. Methods This cross-sectional study was conducted in students who attended three senior high schools in padang. Subjects comprised 28 obese and 28 non-obese adolescents. The age of the subjects ranged from 14-18 years. Obesity criteria were based on body mass index (BMI) measurements. Fasting serum glucose level was measured by glucose hexokinase photometry and serum insulin was measured by chemiluminesence immunoassay. plasma visfatin was measured by enzyme-linked immunosorbent assay (ELISA). The insulin resistance index was estimated from fasting serum insulin and glucose levels using the homeostatic model assessment for insulin resistance (HOMA-IR). Differences in the variables were tested using independent T-test and Mann-Whitney test, depending on the distribution of the variables. Results The mean plasma visfatin level was significantly higher in the obese than in the control group [2.55 (SD 1.54) vs. 1.61 (SD 0.64) ng/mL, respectively; (p=0.005)]. The insulin resistant group had significantly higher mean plasma visfatin level than the non-resistant group [3.61 (SD 1.59) vs. 1.96 (SD 1.18) ng/mL, respectively; (p=0.004)]. Conclusion Obese adolescents with insulin resistance have signifcantly higher plasma visfatin levels compared to those without insulin resistance.

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Visfatin in juvenile obesity – the effect of obesity intervention and sex

Abstract: Central obesity combined with HI/IR contributes to visfatin elevation. Visfatin association with metabolic/biochemical variables is gender dependent. Diet + enhanced physical activity are effective in visfatin reduction, the degree of which depends on baseline visfatin.

Cited by 16 publications

References 41 publications

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

Decreased cardiotrophin-1 levels are associated with a lower risk of developing the metabolic syndrome in overweight/obese children after a weight loss program

Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Visfatin levels in non-obese, obese, and insulin resistant adolescents

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