Visible-light-controllable drug release from multilayer-coated microneedles

Zhang, Zhiqiang; Ye, Haixia; Wang, Juan; Zhang, TaoYe; You, Qingliang; Li, Haohuan; He, Rongxiang; Chen, Yong; Zhang, Weiying; Cao, Yiping

doi:10.1039/c7tb01546a

Cited by 15 publications

(12 citation statements)

References 27 publications

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“…Although there is a slight drop in mechanical strength after coating of LA on the surface MNs, they still have enough strength (0.47 N/needle) to penetrate into the skin (Figure S5A). 35,36 The morphology changes of microneedles can be observed visibly compared with the initial state (Figure S5B-a) after the mechanical experiment (Figure S5B-b). The tips of MNs showing a severe bending with no break indicates excellent flexibility and toughness of the LA/CaCO 3 /PVP MNs.…”

Section: Resultsmentioning

confidence: 97%

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Liu

Yang

Jiang

et al. 2018

ACS Biomater. Sci. Eng.

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This study described near-infrared (NIR) light-responsive polymer-nanodot composite microneedles (MNs) used for on-demand transdermal drug delivery. Bismuth (Bi) nanodots stabilized by poly(vinylpyrrolidone) (PVP) as a photothermal conversion agent and metformin as an antidiabetic drug were introduced into the dissolving MNs coated with lauric acid (LA). When the MNs were irradiated with NIR light, light-to-heat transduction induced by the Bi nanodots caused the LA to melt. As a result, the polymer matrix was dissolved after absorbing the interstitial fluid, enabling the encapsulated metformin release from the MNs into skin tissue. Compared with subcutaneous injection of metformin, the administration using the Bi nanodots-induced NIR responsive MNs developed in the current research exhibited a remarkable hypoglycemic effect in vivo. This work indicates that the as-fabricated Bi nanodot-induced NIR responsive and LA-coated MNs have potential applications in diabetes treatment. Additionally, these artificial MNs also present a promising platform for delivering other therapeutic drugs.

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Section: Resultsmentioning

confidence: 97%

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Liu

Yang

Jiang

et al. 2018

ACS Biomater. Sci. Eng.

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Section: Stimuli-responsive Microneedlesmentioning

confidence: 99%

“…The long-term NIR exposure can lead to tissue damage. To overcome this issue, Zheng et al developed Vis-light-responsive coated MNs to deliver drug via transdermal route in an “on–off” switchable strategy (Figure B) . The MN patch was fabricated by a layer-by-layer (LbL) coating of β-cyclodextrin-modified poly(acrylic acid) (PAA-β-CD), on which model drugs [neutral red (NR) and safranine T (ST)] were “skulked” into β-CD on a polyanion.…”

Section: Stimuli-responsive Microneedlesmentioning

confidence: 99%

Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

et al. 2022

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Microneedles are one of the most prominent approaches capable of physically disrupting the stratum corneum without devastating the deeper tissues to deliver both small molecules and macromolecules into the viable epidermis/dermis for local/systemic effects. Over the past two decades, microneedles have caught the attention of many researchers because of their outstanding advantages over oral and parenteral drug delivery systems such as self-administration, pain-free, steady-plasma concentration maintenance, avoidance of first-pass hepatic biotransformation, and so on. So far, scientists have reported various types of microneedle patches to deliver the loaded therapeutics as soon as the microneedles are inserted into the skin, regardless of the demand for therapeutics to treat a specific condition. This way of drug delivery can lead to potential risks such as poor therapeutic efficacy or drug overdose. The stimuliresponsive microneedles are the most predominant tool to achieve the on-demand/need-based drug delivery, leading to safe and effective treatment. Various natural and synthetic polymers that can undergo significant transitions such as swelling, shrinking, dissolution, or disintegration play a pivotal role in the development of stimuli-responsive microneedles. The current Review provides brief information about the history, emergence, type, and working principles of microneedles. Furthermore, it selectively discusses various exogenous and endogenous stimuli-responsive microneedles along with their mechanism of action involved in treating different disease conditions. Collaterally, the emergence of "closed-loop" combinatorial stimuli-responsive microneedle patches for precise delivery of therapeutics is meticulously canvassed. Subsequently, it covers the patents of different stimuli-responsive microneedles and further highlights the existing challenges and future perspectives concerning clinical application and large-scale production.

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“…To achieve controllable drug release, microneedlebased active drug release systems have been developed. Active drug release systems, such as iontophoresis-driven [129], thermal-driven [130], vibration-assisted [131], and light-controllable [132] microneedle drug delivery systems, have been exploited to control and accelerate drug diffusion and absorption. Li et al [133] established an iontophoresis-driven porous microneedle patch for active drug release, as shown in Table 9.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

A Review of Nano/Micro/Milli Needles Fabrications for Biomedical Engineering

Liu

Zheng

et al. 2022

Chin. J. Mech. Eng.

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Needles, as some of the most widely used medical devices, have been effectively applied in human disease prevention, diagnosis, treatment, and rehabilitation. Thin 1D needle can easily penetrate cells/organs by generating highly localized stress with their sharp tips to achieve bioliquid sampling, biosensing, drug delivery, surgery, and other such applications. In this review, we provide an overview of multiscale needle fabrication techniques and their biomedical applications. Needles are classified as nanoneedles, microneedles and millineedles based on the needle diameter, and their fabrication techniques are highlighted. Nanoneedles bridge the inside and outside of cells, achieving intracellular electrical recording, biochemical sensing, and drug delivery. Microneedles penetrate the stratum corneum layer to detect biomarkers/bioelectricity in interstitial fluid and deliver drugs through the skin into the human circulatory system. Millineedles, including puncture, syringe, acupuncture and suture needles, are presented. Finally, conclusions and future perspectives for next-generation nano/micro/milli needles are discussed.

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Visible-light-controllable drug release from multilayer-coated microneedles

Abstract: A method for the generation of visible-light-controllable drug release on microneedles is developed by host–guest chemistry. In response to visible light irradiation, model drugs encapsulated on polyelectrolyte multilayers transfer into the skin following brief microneedle application.

Cited by 15 publications

References 27 publications

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

A Review of Nano/Micro/Milli Needles Fabrications for Biomedical Engineering

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