Visible-light-driven selective difluoroalkylation of α-CF₃ alkenes to access CF₂-containing gem-difluoroalkenes and trifluoromethylalkanes

Abstract

A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem-difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.

Visible-light-induced hydroxycarboxylation of α-trifluoromethylstyrenes to construct densely functionalized α-CF3 tertiary alcohols

“…7 d ,8 In addition, α-trifluoromethylstyrenes have always been important structural units 9 and are widely used to synthesize various fluorinated compounds with diverse structures. In the past few years, many transformations of α-trifluoromethylstyrenes have been developed, such as alkylation, 10 arylation, 11 benzylation, 12 ammonification 13 gem -difluoroalkylation, 14 etc. (Scheme 1d).…”