Visible‐Light‐Mediated Synthesis of Bicalutamide by Regioselective Hydroxysulfonylation of Acrylamides

Abstract

Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N‐arylacrylamide is described. This approach involves a one‐pot hydroxysulfonylation reaction via a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows the access to a broad range of α‐hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process.