Visit-to-Visit Variability of Lipids Measurements and the Risk of Stroke and Stroke Types: A Prospective Cohort Study

Abstract

Background and Purpose Previous studies suggested increased visit-to-visit variability of total cholesterol (TC) is associated with stroke. This study aimed to investigate the associations of various lipids measurements variability and the risk of stroke and stroke type (ischemic and hemorrhagic stroke).Methods Fifty-one thousand six hundred twenty participants in the Kailuan Study without history of myocardial infarction, stroke, and cancer who underwent three health examinations during 2006 to 2010 were followed for incident stroke. Variability in TC, triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) measurements were measured using the coefficient of variation (CV), standard deviation (SD), variability independent of the mean (VIM), and average real variability (ARV).Results During a median of 6.04 years of follow-up, 1,189 incident stroke (1,036 ischemic and 160 hemorrhagic stroke) occurred. In the multivariable-adjusted model, the hazard ratio (HR) comparing participants in the highest versus lowest quartile of CV of HDL-C were 1.21 (95% confidence interval [CI], 1.02 to 1.45; <i>P</i> for trend=0.013) for ischemic stroke. The highest quartile of CV of LDL-C was associated with 2.17-fold risk of hemorrhagic stroke (HR, 2.17; 95% CI, 1.25 to 3.75; <i>P</i> for trend=0.002) compared with the lowest quartile. We did not observe any significant association between TC and triglycerides variability with any of stroke. Consistent results were obtained when calculating variability index using SD, VIM, or ARV.Conclusions These findings suggest the high visit-to-visit HDL-C and LDL-C variability were associated with an increased incidence of ischemic and hemorrhagic stroke, respectively.

Prevalência da Síndrome Metabólica e seus componentes na população adulta brasileira

“…We believe it is a significant advance for health assessment at the national level since many metabolic disorders have a prolonged sub-clinical phase, and delayed diagnoses can be inconvenient in preventing more severe events. For example, it is noteworthy that dyslipidemias underpinning MetS are related to a higher risk of cardiovascular diseases (CVD), including stroke 28,29 . Studies with laboratory data allow estimating the prevalence of health problems in subclinical stages and populations with less access to health services, and therefore, still without diagnosis and treatment.…”

Triglyceride-glucose index and the risk of stroke and its subtypes in the general population: an 11-year follow-up

“…The Kailuan Study is a prospective cohort study conducted in the Kailuan community in Tangshan City, China [ 9 ]. The detailed design of the Kailuan study have been described previously [ 10 ].…”

“…The outcome was the first occurrence of stroke, including ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage according to the World Health Organization criteria [ 13 ]. Adjudication of incident stroke in the Kailuan Study was described previously [ 9 ]. In brief, participants were followed up at biennial routine medical examinations until December 31, 2017.…”

Serviço farmacêutico: rastreamento da síndrome metabólica em servidores de uma Universidade Pública em Belém-PA

“…Pois o uso de dados laboratoriais permite que se obtenha resultados fiéis à condição de saúde do indivíduo, e possibilitam avaliar a prevalência de danos à saúde em estágios iniciais, subclínicos, sem diagnóstico e tratamento. A identificação de distúrbios cardiometabólicos em tempo oportuno permite a prevenção de eventos mais graves como a SM (Lee et al, 2017;Wang et al, 2020).…”