Visual and visuomotor interhemispheric transfer time in older adults

Scally, Brian; Burke, Melanie Rose; Bunce, David; Delvenne, Jean‐François

doi:10.1016/j.neurobiolaging.2018.01.005

Cited by 9 publications

(8 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This release from corticocortical alignment of representation maps is referred to as anisomorphic cortical reorganization, which may alter interhemispheric temporal synchrony through modulation of callosal functional connectivity. Interhemispheric asynchrony in NH reflects transfer time ( Henshall et al 2012 ; Scally et al 2018 ) for a signal to cross from contralateral to ipsilateral auditory cortex via modular callosal connections ( Code & Winer 1986 ; Rouiller et al 1991 ). In an excitatory model of corpus callosum function, where information reinforcement and hemispheric integration are critical features ( Kinsbourne 1970 ; Guiard 1980 ; Yazgan et al 1995 ; Bloom & Hynd 2005 ; van der Knaap & van der Ham 2011 ), these transcallosal signals may assist with decision-making on uncertain sound objects, such as those embedded in noise.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss

et al. 2021

View full text Add to dashboard Cite

Objectives: Auditory cortical activation of the two hemispheres to monaurally presented tonal stimuli has been shown to be asynchronous in normal hearing (NH) but synchronous in the extreme case of adult-onset asymmetric hearing loss (AHL) with single-sided deafness. We addressed the wide knowledge gap between these two anchoring states of interhemispheric temporal organization. The objectives of this study were as follows: (1) to map the trajectory of interhemispheric temporal reorganization from asynchrony to synchrony using magnitude of interaural threshold difference as the independent variable in a cross-sectional study and (2) to evaluate reversibility of interhemispheric synchrony in association with hearing in noise performance by amplifying the aidable poorer ear in a repeated measures, longitudinal study. Design: The cross-sectional and longitudinal cohorts were comprised of 49 subjects (AHL; N = 21; 11 male, 10 female; mean age = 48 years) and NH (N = 28; 16 male, 12 female; mean age = 45 years). The maximum interaural threshold difference of the two cohorts spanned from 0 to 65 dB. Magnetoencephalography analyses focused on latency of the M100 peak response from auditory cortex in both hemispheres between 50 msec and 150 msec following monaural tonal stimulation at the frequency (0.5, 1, 2, 3, or 4 kHz) corresponding to the maximum and minimum interaural threshold difference for better and poorer ears separately. The longitudinal AHL cohort was drawn from three subjects in the cross-sectional AHL cohort (all male; ages 49 to 60 years; varied AHL etiologies; no amplification for at least 2 years). All longitudinal study subjects were treated by monaural amplification of the poorer ear and underwent repeated measures examination of the M100 response latency and quick speech in noise hearing in noise performance at baseline, and postamplification months 3, 6, and 12. Results: The M100 response peak latency values in the ipsilateral hemisphere lagged those in the contralateral hemisphere for all stimulation conditions. The mean (SD) interhemispheric latency difference values (ipsilateral less contralateral) to better ear stimulation for three categories of maximum interaural threshold difference were as follows: NH (≤ 10 dB)—8.6 (3.0) msec; AHL (15 to 40 dB)—3.0 (1.2) msec; AHL (≥ 45 dB)—1.4 (1.3) msec. In turn, the magnitude of difference values were used to define interhemispheric temporal organization states of asynchrony, mixed asynchrony and synchrony, and synchrony, respectively. Amplification of the poorer ear in longitudinal subjects drove interhemispheric organization change from baseline synchrony to postamplification asynchrony and hearing in noise performance improvement in those with baseline impairment over a 12-month period. Conclusions: Interhemispheric temporal organization in AHL was anchored between states of asynchrony in NH and synchrony in single-sided deafness. For asymmetry magn...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Thus, different callosal sections are embedded in different functional interhemispheric networks and the here observed differences in trajectories likely reflect the development of these network. For example, it can be speculated that the splenium's role in basic perception processes, rather than in higher cognition, protects it longer from detectable decline in older age (Madden et al, 2009;Scally, Burke, Bunce, & Delvenne, 2018). On the other hand, histological analyses of the corpus callosum suggest that subsections also differ substantially in their axon composition.…”

Section: Discussionmentioning

confidence: 99%

Lifespan trajectories of relative corpus callosum thickness: regional differences and cognitive relevance.

Danielsen¹,

Pineiro²,

Mowinckel³

et al. 2020

Preprint

View full text Add to dashboard Cite

The cerebral hemispheres are specialized for different cognitive functions and receive divergent information from the sensory organs, so that the interaction between the hemispheres is a crucial aspect of perception and cognition. At the same time, the major fiber tract responsible for this interaction, the corpus callosum, shows a structural development across the lifespan which is over-proportional. That is, compared to changes in overall forebrain volume, the corpus callosum shows an accentuated growth during childhood, adolescence, and early adulthood, as well as pronounced decline in older age. However, this over-proportionality of growth and decline along with potential consequences for cognition, have been largely overlooked in empirical research. In the present study we systematically address the proportionality of callosal development in a large mixed cross-sectional and longitudinal sample (1867 datasets from 1014 unique participants), covering the human lifespan (age range 4 to 93 years), and examine the cognitive consequences of the observed changes. Relative corpus callosum thickness was measured at 60 segments along the midsagittal surface, and lifespan trajectories were clustered to identify callosal subsections of comparable lifespan development. While confirming the expected inverted u-shaped lifespan trajectories, we also found substantial regional variation. Compared with anterior clusters, posterior sections exhibited an accentuated growth during development which extends well into the third decade of life, and a protracted decline in older age which is delayed by about 10 years (starting mid to late 50s). We further showed that the observed longitudinal changes in relative thickness of the mid splenium significantly mediates age-related changes in tests assessing verbal knowledge and non-verbal visual-spatial abilities across the lifespan. In summary, we demonstrate that analyzing the proportionality of callosal growth and decline offers valuable insight into lifespan development of structural connectivity between the hemispheres, and suggests consequences for the cognitive development of perception and cognition.

show abstract

“…The capacity for information transfer between hemispheres progressively improves until around the age of 10-14 years, when it reaches performance levels typical of adulthood. Starting around the sixth decade of life, there is a progressive decline in performance (Boyson, 2013;Reuter-Lorenz & Stanczak, 2000;Scally, Burke, Bunce, & Delvenne, 2018). For example, significant differences have been reported between adults aged 35-45 and 55-60 years (Bellis & Wilber, 2001).…”

Section: Introductionmentioning

confidence: 99%

Music Playing and Interhemispheric Communication: Older Professional Musicians Outperform Age-Matched Non-Musicians in Fingertip Cross-Localization Test

Piccirilli

Palermo²,

Germani

et al. 2020

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Objective: Numerous investigations have documented that age-related changes in the integrity of the corpus callosum are associated with age-related decline in the interhemispheric transfer of information. Conversely, there is accumulating evidence for more efficient white matter organization of the corpus callosum in individuals with extensive musical training. However, the relationship between making music and accuracy in interhemispheric transfer remains poorly explored. Methods: To test the hypothesis that musicians show enhanced functional connectivity between the two hemispheres, 65 professional musicians (aged 56–90 years) and 65 age- and sex-matched non-musicians performed the fingertip cross-localization test. In this task, subjects must respond to a tactile stimulus presented to one hand using the ipsilateral (intra-hemispheric test) or contralateral (inter-hemispheric test) hand. Because the transfer of information from one hemisphere to another may imply a loss of accuracy, the value of the difference between the intrahemispheric and interhemispheric tests can be utilized as a reliable measure of the effectiveness of hemispheric interactions. Results: Older professional musicians show significantly greater accuracy in tactile interhemispheric transfer than non-musicians who suffer from age-related decline. Conclusions: Musicians have more efficient interhemispheric communication than age-matched non-musicians. This finding is in keeping with studies showing that individuals with extensive musical training have a larger corpus callosum. The results are discussed in relation to relevant data suggesting that music positively influences aging brain plasticity.

show abstract

Visual and visuomotor interhemispheric transfer time in older adults

Cited by 9 publications

References 66 publications

Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss

Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss

Lifespan trajectories of relative corpus callosum thickness: regional differences and cognitive relevance.

Music Playing and Interhemispheric Communication: Older Professional Musicians Outperform Age-Matched Non-Musicians in Fingertip Cross-Localization Test

Contact Info

Product

Resources

About