Visual Dysfunction Associated with Diabetic Retinopathy

Jackson, Gregory R.; Barber, Alistair J.

doi:10.1007/s11892-010-0132-4

Cited by 82 publications

(84 citation statements)

References 39 publications

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“…A similar behavior has occurred in DM2 (Humphrey et al, 1994). Readers are referred to recent reviews on this topic (Jackson & Barber, 2010;Ockrim & Yorston, 2010).…”

Section: Microangiophatic Complications 231 Diabetic Retinopathy (Dr)supporting

confidence: 60%

Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

Garcı́a¹,

Wolff²,

Araya³

et al. 2011

Medical Complications of Type 2 Diabetes

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“…A similar behavior has occurred in DM2 (Humphrey et al, 1994). Readers are referred to recent reviews on this topic (Jackson & Barber, 2010;Ockrim & Yorston, 2010).…”

Section: Microangiophatic Complications 231 Diabetic Retinopathy (Dr)supporting

confidence: 60%

Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

Garcı́a¹,

Wolff²,

Araya³

et al. 2011

Medical Complications of Type 2 Diabetes

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“…Eye diseases, such as uveitis, age-related macular degeneration and diabetic retinopathy involved the posterior segment (retina, choroids and vitreous) can lead to irreversible visual impairments (Congdon et al, 2004;Durrani et al, 2004;Jackson & Barber, 2010). These diseases have a chronic nature and need long-time therapy.…”

Section: Introductionmentioning

confidence: 99%

A study of the dexamethasone sodium phosphate release properties from a periocular capsular drug delivery system

et al. 2014

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The aim of this study was to investigate whether a periocular capsular drug delivery system (DDS) can release dexamethasone sodium phosphate (DEXP) in vitro and in vivo to the posterior segment of rabbit's eye. In vitro, the periocular capsular DDS containing 2 mg/ml or 5 mg/ml DEXP was immersed in modified Franz diffusion cell. Four-hundred microliters of liquid was aspirated at 0.5, 1, 2, 4, 8, 24 and 48 h for determination. In vivo, the DEXP-filled periocular capsular DDS was implanted into the sub-Tenon's sac of the New Zealand rabbit. DEXP concentration at the serum aqueous humor, cornea, iris, lens, ciliary body, vitreous, retina, choroids and sclera was quantified at 1, 3, 7, 14, 28 and 56 d after implantation. The DEXP concentration was determined by ultra-performance liquid chromatography-tandem mass spectrometry. In vitro, the periocular capsular DDS released the DEXP in time-dependent manner from 1/2 to 48 h. In vivo, the concentrations of the DEXP at the retina, choroids, ciliary body and iris were 123.11 (91.23, 732.61) ng/g, 362.46 ± 330.46 ng/g, 71.64 (71.35, 180.21) ng/g and 192.50 ± 42.66 ng/g, respectively, at 56 d after implantation. Minimal DEXP was found in the aqueous, serum and vitreous. Our results demonstrated that DEXP could be sustained released from the periocular capsular DDS, which indicated that the periocular capsular DDS might be a potential candidate of transscleral drug delivery for the management of posterior segment diseases.

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“…3 Several forms of retinal and visual dysfunction, however, are evident before the onset of clinical indicators. 4 Some of these early deficits include slow dark adaptation, 5 elevated rod and cone thresholds, [6][7][8] diminished photopic contrast sensitivity, 9 and impaired electroretinographic (ERG) responses. 6,10,11 The wide variety of retinal and visual deficits show as a potential consequence of diabetes acting at multiple stages of the visual pathway.…”

mentioning

confidence: 99%

Loss of Scotopic Contrast Sensitivity in the Optomotor Response of Diabetic Mice

Umino

Solessio

2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Diabetes reduces retinal and visual sensitivity to dim light flashes. However, the impact of diabetes on contrast sensitivity in dim light is unknown. Based on the lowered visual sensitivity previously observed, we hypothesized that contrast sensitivity would similarly be reduced. We therefore examined scotopic contrast sensitivity of the optomotor response in the Ins2 Akita/+ mouse model of type 1 diabetes. METHODS.A longitudinal study of spatial and temporal contrast sensitivity in Ins2 Akita/+ mice and wild-type Ins2 +/+ littermates was conducted. Contrast sensitivity of the optomotor response to rotating gratings of various spatial and temporal frequencies was measured at a dim luminance level (2.6 Á 10 À5 cd/m 2 ) known to elicit rod-but not cone-driven responses.RESULTS. An early, progressive loss in scotopic contrast sensitivity was observed in Ins2Akita/+ mice that was absent from Ins2 +/+ littermate controls. The loss in contrast sensitivity developed over a 3-to 4-month period after the onset of hyperglycemia. Ins2Akita/+ mice exhibited a nonselective 40% loss in sensitivity to all spatial frequencies and a selective loss in sensitivity to fast but not to slow varying gratings (temporal frequencies >0.1 Hz or, equivalently, speeds >3 deg/s). Such losses in sensitivity were prevented by glycemic control with insulin treatment.CONCLUSIONS. An association between a model of type 1 diabetes and scotopic contrast sensitivity of the optomotor response is indicated. Ins2Akita/+ mice exhibit a uniform loss in optomotor contrast sensitivity to all spatial frequencies that, unexpectedly, can be explained as being secondary to a retinal or central loss in sensitivity to high temporal frequencies.

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Visual Dysfunction Associated with Diabetic Retinopathy

Cited by 82 publications

References 39 publications

Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

Genetics of Endothelial Damage Associated to Diabetes Mellitus Type 2

A study of the dexamethasone sodium phosphate release properties from a periocular capsular drug delivery system

Loss of Scotopic Contrast Sensitivity in the Optomotor Response of Diabetic Mice

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