Visual evoked cortical potentials and pattern electroretinograms in Parkinson's disease and control subjects.

Nightingale, Sophie; Mitchell, Keith; Howe, J W

doi:10.1136/jnnp.49.11.1280

Cited by 112 publications

(54 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VEPs have been shown to be a highly sensitive but not especially specific test for optic neuritis. A unilateral substantially delayed VEP with minimal amplitude reduction is highly suggestive of a demyelinating optic neuropathy, for example, recovered MSON or subclinical involvement of the optic nerve in MS. VEP abnormalities will also be seen in patients with refractive errors, pure retinal dysfunction, compressive lesions of the optic nerve, Parkinson disease 99 or migraine. 100 Normality of both the ERG and VEP supports the differential diagnosis of nonorganic aetiology if performed after other investigations failed to yield a diagnosis.…”

Section: Visual Evoked Potentialsmentioning

confidence: 99%

The investigation of acute optic neuritis: a review and proposed protocol

et al. 2014

View full text Add to dashboard Cite

| Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

show abstract

Section: Visual Evoked Potentialsmentioning

confidence: 99%

The investigation of acute optic neuritis: a review and proposed protocol

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In the retina, dopamine is the predominant catecholamine and functions as a neurotransmitter and neuromodulator involved in light-adaptive retinal processes (Denis et al, 1993). Abnormalities in visual processing in Parkinson's disease, including deficient contrast sensitivity and abnormalities in visually evoked potentials, appear linked to deficiencies in retinal dopamine systems (Nightingale et al, 1986;Harnois and Di Paolo, 1990;Price et al, 1992;Djamgoz et al, 1997). Disturbances of digestive function, such as constipation, are common in Parkinson's disease and may be related to defects in gastrointestinal dopamine systems now also identified in the disorder Singaram et al, 1995).…”

Section: Eisenhofer Et Almentioning

confidence: 99%

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

2004

View full text Add to dashboard Cite

“…Tyrosine hydroxylase immunoreactivity (N'Guyen Legros, 1988) and dopamine concentrations (Harmois, 1990) are also lower in retina of parkinsonians as compared with control subjects. Abnormalities of pattern-VEP and ERG have also been demonstrated in parkinsonians (Bodis-Wollner et al, 1987;Ellis et al, 1987;Nightingale et al, 1986;Stanzione et al, 1989 VEP abnormalities depend on the spatial and temporal frequencies of the visual stimulus (Bodis-Wollner et al, 1986) and are reversed by levodopa treatment (BodisWollner, 1990;Bodis-Wollner et al, 1986). Moreover, thioridazine, a neuroleptic, alters ERG in normal subjects (Filip & Balik, 1978), and chlorpromazine, another dopaminergic blocker, induces alterations of VEP and ERG which are dependent on the spatial frequency of stimulation (Bartel et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Selective effects of low doses of apomorphine on spatiotemporal contrast sensitivity in healthy volunteers: a double‐blind placebo‐ controlled study.

Blin¹,

Mestre²,

Masson³

et al. 1991

Brit J Clinical Pharma

View full text Add to dashboard Cite

1. Apomorphine (1 and 5 micrograms kg‐1) and placebo were given to nine normal volunteers, using a Latin‐square design and double‐blind procedures. The visual perception of static and moving patterns (static and motion contrast sensitivity) was evaluated before and 15 min after the dose administration. 2. Apomorphine (1 and 5 micrograms kg‐1), as compared with placebo, led to a significant overall reduction of the visual perception of movement. This effect was dose‐related, and apomorphine (5 micrograms kg‐1) induced a more pronounced decrease in the visual perception of movement than apomorphine (1 microgram kg‐1). With apomorphine (5 micrograms kg‐1), the reduction was more pronounced for low spatial frequencies, and was linearly inversely correlated to the spatial frequency for a temporal frequency of 3 Hz. Finally, no significant effect of apomorphine was observed for sensitivity to static patterns. 3. Several non exclusive hypotheses may be suggested: The effects of apomorphine may result from stimulation of retinal D1‐ and/or D2‐dopaminergic receptors. Apomorphine may increase the surround inhibition of ganglion cells' receptive‐fields. This modification of the centre‐surround balance may explain the decrease in contrast sensitivity for low spatial frequencies. The specific effects of apomorphine on the visual perception of movement support the hypothesis that apomorphine preferentially affects the magnocellular pathway which mediates sensitivity to moving patterns.

show abstract

Visual evoked cortical potentials and pattern electroretinograms in Parkinson's disease and control subjects.

Cited by 112 publications

References 21 publications

The investigation of acute optic neuritis: a review and proposed protocol

The investigation of acute optic neuritis: a review and proposed protocol

Catecholamine Metabolism: A Contemporary View with Implications for Physiology and Medicine

Selective effects of low doses of apomorphine on spatiotemporal contrast sensitivity in healthy volunteers: a double‐blind placebo‐ controlled study.

Contact Info

Product

Resources

About