Visual Impairment, Age-Related Eye Diseases, and Cognitive Function

Ong, Shin Yeu; Cheung, Carol Y.; Li, Xiang; Lamoureux, Ecosse L.; Ikram, M. Kamran; Ding, Jie; Cheng, Ching‐Yu; Haaland, Benjamin; Saw, Seang Mei; Venketasubramanian, Narayanaswamy; Chen, Christopher; Wong, Tien Yin

doi:10.1001/archophthalmol.2012.152

Cited by 121 publications

(119 citation statements)

References 48 publications

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“…Individuals with severe visual impairment who had a Grade 1 (0.01 or less visual acuity in bilateral eyes) or Grade 2 ([1] monocular blindness and 0.02 or less vision in the other eye, or [2] 0.02 or less vision in bilateral eyes) disability were recruited for the study. Of 61 affiliated organizations, 60 agreed to cooperate in the study.…”

Section: Visually Impaired Individualsmentioning

confidence: 99%

“…[1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment. [1][2][3][4][5][6][7][8][9] Therefore, those individuals might be at risk for lower health-related quality of life (QOL). [7][8][9][10] Sleep-related problems have been observed frequently in visually impaired individuals.…”

Section: Introductionmentioning

confidence: 99%

“…Considering the issues described above, the aims of this questionnaire-based cross-sectional study were to (1) estimate the prevalence of sleep-related problems among Japanese visually impaired people, particularly addressing the presence/ absence of LP, and to (2) explore the association between sleep-related problems and physical/mental QOL among this population.…”

Section: Introductionmentioning

confidence: 99%

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A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Tamura

Sasai-Sakuma

Morita

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objectives: This questionnaire-based cross-sectional study was conducted (1) to estimate the prevalence of sleep-related problems, and (2) to explore factors associated with lower physical/mental quality of life (QOL), particularly addressing sleep-related problems among Japanese visually impaired people. Methods: This nationwide questionnaire-based survey was administered to visually impaired individuals through the Japan Federation of the Blind. Visually impaired individuals without light perception (LP) (n = 311), those with LP (n = 287), and age-matched and gender-matched controls (n = 615) were eligible for this study. Study questionnaires elicited demographic information, and information about visual impairment status, sleep-related problems, and health-related quality of life. Results: Visually impaired individuals with and without LP showed higher prevalence rates of irregular sleep-wake patterns and difficulty maintaining sleep than controls (34.7% and 29.4% vs. 15.8%, 60.1% and 46.7% vs. 26.8%, respectively; p < 0.001). These sleep-related problems were observed more frequently in visually impaired individuals without LP than in those with LP. Non-restorative sleep or excessive daytime sleepiness was associated with lower mental/physical QOL in visually impaired individuals with LP and in control subjects. However, visually impaired individuals without LP showed irregular sleepwake pattern or difficulty waking up at the desired time, which was associated with lower mental/physical QOL. Conclusions: Sleep-related problems were observed more frequently in visually impaired individuals than in controls. Moreover, the rates of difficulties were higher among subjects without LP. Sleep-related problems, especially circadian rhythm-related ones, can be associated with lower mental/physical QOL in visually impaired individuals without LP. Keywords: circadian rhythm sleep-wake disorder, health-related quality of life, light perception, prevalence, sleep-related problems, visual impairment I NTRO DUCTI O NVisually impaired individuals are likely to have any of several comorbid mental/physical disorders including diabetes mellitus, hypertension, cognitive impairment, and depression/ anxiety. [1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment.1-9 Therefore, those individuals might be at risk for lower health-related quality of life (QOL). 7-10Sleep-related problems have been observed frequently in visually impaired individuals.11-15 Reportedly, especially in people without light perception (LP), inhibited transmission of light signals to the suprachiasmatic nuclei might cause sleeprelated problems because of external desynchronization of the biological clock. 16,17 Indeed, the rate of circadian-related sleepwake disorders is likely to be higher among visually impaired individuals without LP than among those with LP.12 In Japan, no large nationwide study of this subject has ever been reported. The actual prevalence of sleep-related problems amon...

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Section: Visually Impaired Individualsmentioning

confidence: 99%

“…[1][2][3][4][5][6] The severity of these mental/physical disorders is reportedly correlated with visual impairment.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

Tamura

Sasai-Sakuma

Morita

et al. 2016

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

show abstract

“…[2][3][4] Neurodegenerative disease, psychotropic medications, and psychological factors may all manifest with or exacerbate symptoms of visual dysfunction. [5][6][7][8][9][10][11][12][13][14] Such multifactorial visual complaints are difficult to diagnose, and may be best approached by a multidisciplinary team. 3 The Visual Perception Clinic in the Newcastle Eye Centre provides such a multidisciplinary service.…”

Section: Introductionmentioning

confidence: 99%

A novel, multidisciplinary clinic for complex visual problems in older people

Han

Jefferis

Archibald

et al. 2012

Eye

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Background Visual symptoms in older people can be complex and inadequately explained by eye pathology alone. Psychological and neurodegenerative processes may manifest as complex visual symptoms, and thus some patients may be poorly served by a purely ophthalmic approach. We have developed a novel multidisciplinary clinic with input from neurology, ophthalmology, and psychiatric specialists. Here, we describe the patient population, disease prevalence, and potential impact of this new clinic. Methods A retrospective audit of paper and electronic records from June 2010 to February 2012 and selected case reports. Results Between June 2010 and February 2012 48 patients attended the clinic. Notes were available for 47 (98%). Mean age was 76.2 (range 48-92). The main presenting complaints were hallucinations, followed by nonspecific visual deficit, double vision, blurred vision, and visuospatial deficit. Cognitive impairment was noted in 68% (32/47) of patients, of which 16/32 (50%) were new diagnoses. We were able to give a diagnosis to 98% (46/47) of patients; of these, 74% (35/46) were new diagnoses. A total of 6% (3/47) were felt to have presentations attributable to eye pathology alone, whereas 89% (42/47) were felt to have a neuropsychiatric component. Management included referral to other clinics for continuing care in 43% (20/47) and initiation of therapy in 36% (17/47). The three case reports demonstrate cases, where our multidisciplinary approach aided diagnosis and management of patients with complex visual symptoms. Conclusion A combined clinic with neurological, ophthalmic, and psychiatric

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Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

et al. 2020

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IMPORTANCE With the rapidly aging population, the burden of visual impairment (VI) and cognitive decline is expected to increase. Previous cross-sectional studies suggest an association between these 2 health outcomes. However, few longitudinal reports have examined this association, and to our knowledge, no studies have been performed in Asian populations. Further investigation on this association may help to better identify individuals at risk of cognitive decline. OBJECTIVE To examine the longitudinal association between VI and decline in cognitive function in a multiethnic Asian population. DESIGN, SETTING, AND PARTICIPANTSIn this longitudinal, population-based, prospective cohort study, Chinese, Indian, and Malay adults 60 years or older at baseline were recruited from the Singapore Epidemiology of Eye Diseases (SEED) study. At baseline, participants from the SEED study were recruited under 3 studies: the Singapore Malay Eye Study (SiMES;, the Singapore

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Visual Impairment, Age-Related Eye Diseases, and Cognitive Function

Abstract: Older persons with visual impairment, particularly those with visual impairment due to cataract, were more likely to have cognitive dysfunction. Furthermore, among the major age-related eye diseases, only diabetic retinopathy was associated with cognitive dysfunction.

Cited by 121 publications

References 48 publications

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

A Nationwide Cross-Sectional Survey of Sleep-Related Problems in Japanese Visually Impaired Patients: Prevalence and Association with Health-Related Quality of Life

A novel, multidisciplinary clinic for complex visual problems in older people

Association Between Visual Impairment and Decline in Cognitive Function in a Multiethnic Asian Population

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