Visual processing of emotional dynamic faces in 22q11.2 deletion syndrome

Franchini, Martina; Schaer, Marie; Glaser, Bronwyn; Kott-Radecka, Monika; Debanné, M.; Schneider, Maude; Menghetti, Sarah; Sander, David; Eliez, Stéphan

doi:10.1111/jir.12250

Cited by 17 publications

(26 citation statements)

References 43 publications

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“…A–F). These results are in line with previous studies that reported impaired reaction time in patients with 22q11DS during different cognitive tasks [Franchini et al, ; Howley et al, ]. In this study, we further observed that the slower performance of patients with 22q11DS on the CPT task was related to impaired within and between CEN connectivity.…”

Section: Discussionsupporting

confidence: 93%

Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions

Padula

Schaer

Scariati

et al. 2017

Human Brain Mapping

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Large-scale brain networks play a prominent role in cognitive abilities and their activity is impaired in psychiatric disorders, such as schizophrenia. Patients with 22q11.2 deletion syndrome (22q11DS) are at high risk of developing schizophrenia and present similar cognitive impairments, including executive functions deficits. Thus, 22q11DS represents a model for the study of neural biomarkers associated with schizophrenia. In this study, we investigated structural and functional connectivity within and between the Default Mode (DMN), the Central Executive (CEN), and the Saliency network (SN) in 22q11DS using resting-state fMRI and DTI. Furthermore, we investigated if triple network impairments were related to executive dysfunctions or the presence of psychotic symptoms. Sixty-three patients with 22q11DS and sixty-eighty controls (age 6-33 years) were included in the study. Structural connectivity between main nodes of DMN, CEN, and SN was computed using probabilistic tractography. Functional connectivity was computed as the partial correlation between the time courses extracted from each node. Structural and functional connectivity measures were then correlated to executive functions and psychotic symptom scores. Our results showed mainly reduced structural connectivity within the CEN, DMN, and SN, in patients with 22q11DS compared with controls as well as reduced between-network connectivity. Functional connectivity appeared to be more preserved, with impairments being evident only within the DMN. Structural connectivity impairments were also related to executive dysfunctions. These findings show an association between triple network structural alterations and executive deficits in patients with the microdeletion, suggesting that 22q11DS and schizophrenia share common psychopathological mechanisms. Hum Brain Mapp 38:2177-2189, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 93%

Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions

Padula

Schaer

Scariati

et al. 2017

Human Brain Mapping

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“…Patients with 22q11.2DS spent more time on the principal regions of interest and neglected the smaller peripheral figures compared with healthy controls. These results are commensurate with previous evidence showing abnormal scanning of visual stimuli in 22q11.2DS (Franchini et al 2016;McCabe et al 2011;Glaser et al 2010). Additionally, in accordance with the study of McCabe et al (2011), our results provide further evidence that differential visual scanning of individuals with 22q11.2DS is not limited to faces.…”

Section: Discussionsupporting

confidence: 93%

“…These results are commensurate with previous evidence showing abnormal scanning of visual stimuli in 22q11.2DS (Franchini et al . ; Campbell et al . ; McCabe et al .…”

Section: Discussionmentioning

confidence: 99%

“…; Franchini et al . ). The stimuli were divided into three regions of interest (ROIs): ROI total, ROI principal figures and ROI peripheral figures (Fig.…”

Section: Methodsmentioning

confidence: 97%

“…A 5-points calibration procedure was performed before initialising the C-BVRT to ensure that participants' movements were recordable at all distinct points on the screen for both eyes. Per Tobii system and in accordance with previous studies, fixations were defined by a gaze durations of at least 100 ms within a circle measuring 30 pixels in diameter (Glaser et al 2010;Franchini et al 2016). The stimuli were divided into three regions of interest (ROIs): ROI total, ROI principal figures and ROI peripheral figures (Fig.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Does differential visual exploration contribute to visual memory impairments in 22q11.2 microdeletion syndrome?

Bostelmann

Glaser

Zaharia

et al. 2017

J intellect Disabil Res

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What do error patterns in processing facial expressions, social interaction scenes and vocal prosody tell us about the way social cognition works in children with 22q11.2DS?

Peyroux

Babinet

Cannarsa

et al. 2019

Eur Child Adolesc Psychiatry

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Visual processing of emotional dynamic faces in 22q11.2 deletion syndrome

Abstract: These results suggest that individuals with 22q11DS may need either more time or more pronounced emotional cues to correctly label facial expressions.

Cited by 17 publications

References 43 publications

Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions

Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions

Does differential visual exploration contribute to visual memory impairments in 22q11.2 microdeletion syndrome?

What do error patterns in processing facial expressions, social interaction scenes and vocal prosody tell us about the way social cognition works in children with 22q11.2DS?

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