Visual working memory impairments for single items following medial temporal lobe damage

Goodrich, Robin I.; Baer, Trevor L.; Quent, Jörn Alexander; Yonelinas, Andrew P.

doi:10.1016/j.neuropsychologia.2019.107227

Cited by 29 publications

(34 citation statements)

References 76 publications

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“…In our exploratory analyses, we found that storyline reinstatement increased with functional connectivity to hippocampus in mPFC both across participants and across segments (Figure 9), for several (but not all) parameter settings for the analysis. This finding fits with the idea that the hippocampus, which is known to be involved with the reinstatement of episodic memories over days, may also be involved with the reinstatement of recently accumulated memories over shorter lags (for additional evidence in support of this view, see, e.g., Goodrich, Baer, Quent, & Yonelinas, 2019;Hannula & Ranganath, 2009;Staresina & Davachi, 2009;Ezzyat & Olson, 2008;Olson, Moore, Stark, & Chatterjee, 2006). Notably, the degree of interparticipant functional connectivity between hippocampus and cortex did not reliably predict neural reinstatement triggered by motifs in Part C. One possible explanation is that the interparticipant functional connectivity method involves averaging over multiple time points; this may make it less useful for detecting brief reinstatement events triggered by motifs.…”

Section: Discussionsupporting

confidence: 87%

Relating the Past with the Present: Information Integration and Segregation during Ongoing Narrative Processing

Chang

Lazaridi

Yeshurun

et al. 2021

Journal of Cognitive Neuroscience

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This study examined how the brain dynamically updates event representations by integrating new information over multiple minutes while segregating irrelevant input. A professional writer custom-designed a narrative with two independent storylines, interleaving across minute-long segments (ABAB). In the last (C) part, characters from the two storylines meet and their shared history is revealed. Part C is designed to induce the spontaneous recall of past events, upon the recurrence of narrative motifs from A/B, and to shed new light on them. Our fMRI results showed storyline-specific neural patterns, which were reinstated (i.e., became more active) during storyline transitions. This effect increased along the processing timescale hierarchy, peaking in the default mode network. Similarly, the neural reinstatement of motifs was found during Part C. Furthermore, participants showing stronger motif reinstatement performed better in integrating A/B and C events, demonstrating the role of memory reactivation in information integration over intervening irrelevant events.

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Section: Discussionsupporting

confidence: 87%

Relating the Past with the Present: Information Integration and Segregation during Ongoing Narrative Processing

Chang

Lazaridi

Yeshurun

et al. 2021

Journal of Cognitive Neuroscience

View full text Add to dashboard Cite

show abstract

“…In our exploratory analyses, we found that storyline reinstatement increased with functional connectivity to hippocampus in mPFC both across subjects and across segments (Figure 9), for several (but not all) parameter settings for the analysis. This finding fits with the idea that the hippocampus, which is known to be involved with the reinstatement of episodic memories over days, may also be involved with the reinstatement of recently accumulated memories over shorter lags (for additional evidence in support of this view, see, e.g., Ezzyat & Olson, 2008;Goodrich, Baer, Quent, & Yonelinas, 2019;Hannula & Ranganath, 2009;Olson, Ingred, Sledge, Marianna, & Anjan, 2006). Notably, the degree of inter-subject functional connectivity between hippocampus and cortex did not reliably predict neural reinstatement triggered by motifs in part C. One possible explanation is that the inter-subject functional connectivity method involves averaging over multiple time points; this may make it less useful for detecting brief reinstatement events triggered by motifs.…”

Section: Discussionsupporting

confidence: 86%

Relating the past with the present: Information integration and segregation during ongoing narrative processing

Chang

Lazaridi

Yeshurun

et al. 2020

Preprint

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Real-life events unfold continuously over multiple minutes. In this study, in order to examine how the brain continuously integrates information while segregating the accumulated information from irrelevant inputs, a professional writer actively designed a narrative. Two unrelated storylines were interleaved across 30 one-minute segments (ABAB) and merged in a last (C) part, where narrative motifs unique to the A or B storylines recurred to induce reinstatement. Our fMRI results showed neural reinstatement of storylines and motifs in regions with long processing timescale, including the default mode network, suggesting that past information can be segregated from irrelevant inputs in an inactive state for minutes. The reactivated storyline representation was updated by integrating new segments, as reflected by the increasing neural differentiation between storylines. Furthermore, we found a positive correlation between neural reinstatement of motifs and behavioral performance in relating separated events connected by motifs, again demonstrating information integration during continuous processing.

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“…Finally, compared with nsPE patients, sPE patients showed increased activity in AUD and decreased activity in DMN. The temporal gyrus is considered to play a key role in the process of visual and auditory‐related information, 45,46 such as working memory and facial emotion processing 47‐50 . The temporal lobe is also associated with the inhibitory control of ejaculation and the recognition of the visual sexual stimuli 30 .…”

Section: Discussionmentioning

confidence: 99%

“…The temporal gyrus is considered to play a key role in the process of visual and auditory-related information, 45,46 such as working memory and facial emotion processing. [47][48][49][50] The temporal lobe is also associated with the inhibitory control of ejaculation and the recognition of the visual sexual stimuli. 30 In addition, increased activity was found in the temporal lobe of healthy male individuals after ejaculation.…”

Section: Correlations Between Brain Regions With Altered Reho and Pmentioning

confidence: 99%

Aberrant default mode network and auditory network underlying the sympathetic skin response of the penis (PSSR) of patients with premature ejaculation: A resting‐state fMRI study

Chen

Xiang

et al. 2020

Andrology

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Introduction Hyperactivity of the sympathetic nervous system is considered as an important component involved in the pathological mechanisms of premature ejaculation (PE). However, the neural mechanisms of PE with high sympathetic activity are still not well understood. Methods The activity of the sympathetic innervations in the penis was evaluated by the sympathetic skin response of the penis (PSSR) with an electromyograph and evoked potential equipment. Resting‐state functional magnetic resonance imaging (fMRI) data were acquired from 18 PE patients with high sympathetic activity (sPE), 17 PE patients with normal sympathetic activity (nsPE), and 24 healthy controls (HC). We investigated the neural basis of sPE based on the measure of regional homogeneity (ReHo). Moreover, the correlations between brain regions with altered ReHo and PEDT scores and PSSR latencies in the patient group were explored. Results Altered ReHo values among three groups were found in the temporal, cingulated, and parietal cortex in the default mode network (DMN), as well as the temporal cortex in the auditory network (AUD). Compared with HC, Patients with sPE had increased ReHo values of brain regions in DMN, AUD, and decreased ReHo values of brain regions in DMN. In addition, increased ReHo values were found in DMN of patients with nsPE, while decreased ReHo values were found in DMN and the attention network (AN). Moreover, sPE patients had increased ReHo values in AUD and decreased ReHo values in DMN when compared with nsPE patients. Finally, altered ReHo values of brain regions in DMN and AUD were associated with PEDT scores and PSSR latencies in the patient group. Conclusion Our results suggested that PE patients had abnormal ReHo values in DMN, AUD, and AN. Patients with sPE were characterized by increased neuronal activity in AUD and decreased activity in DMN. This highlighted the significances of DMN, AUD, and AN in the pathophysiology of PE and also provided potential neuroimaging biomarkers for distinguishing sPE from nsPE and HC.

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Visual working memory impairments for single items following medial temporal lobe damage

Cited by 29 publications

References 76 publications

Relating the Past with the Present: Information Integration and Segregation during Ongoing Narrative Processing

Relating the Past with the Present: Information Integration and Segregation during Ongoing Narrative Processing

Relating the past with the present: Information integration and segregation during ongoing narrative processing

Aberrant default mode network and auditory network underlying the sympathetic skin response of the penis (PSSR) of patients with premature ejaculation: A resting‐state fMRI study

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