Visualization of Local Concentration and Viscosity Distribution during Glycerol-Water Mixing in a Y-Shape Minichannel: A Proof-of-Concept-Study

Medina, Isabel Batista; Deuerling, Julian; Kumari, Pooja; Scholl, Stephan; Rädle, Matthias

doi:10.3390/mi12080940

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…It has recently been shown that microscopic pockets of different glycerol concentration (and viscosity) can form during the mixing of glycerol and water. [ 29 ] The persistence of these domains can be explained by comparatively slow movement of glycerol molecules between distinct domains of more water‐rich regions. [ 30 ] Nakagawa and Oyama concluded that, due to difference in H‐bond strength, water in water–glycerol mixtures can move faster than in bulk.…”

Section: Resultsmentioning

confidence: 99%

Single‐Particle Tracking and Trajectory Analysis of Fluorescent Nanodiamonds in Cell‐Free Environment and Live Cells

Sigaeva

Hochstetter²,

Bouyim

et al. 2022

Small

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Diamond magnetometry can provide new insights on the production of free radicals inside live cells due to its high sensitivity and spatial resolution. However, the measurements often lack intracellular context for the recorded signal. In this paper, the possible use of single‐particle tracking and trajectory analysis of fluorescent nanodiamonds (FNDs) to bridge that gap is explored. It starts with simulating a set of different possible scenarios of a particle's movement, reflecting different modes of motion, degrees of confinement, as well as shapes and sizes of that confinement. Then, the insights from the analysis of the simulated trajectories are applied to describe the movement of FNDs in glycerol solutions. It is shown that the measurements are in good agreement with the previously reported findings and that trajectory analysis yields meaningful results, when FNDs are tracked in a simple environment. Then the much more complex situation of FNDs moving inside a live cell is focused. The behavior of the particles after different incubation times is analyzed, and the possible intracellular localization of FNDs is deducted from their trajectories. Finally, this approach is combined with long‐term magnetometry methods to obtain maps of the spin relaxation dynamics (or T1) in live cells, as FNDs move through the cytosol.

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Section: Resultsmentioning

confidence: 99%

Single‐Particle Tracking and Trajectory Analysis of Fluorescent Nanodiamonds in Cell‐Free Environment and Live Cells

Sigaeva

Hochstetter²,

Bouyim

et al. 2022

Small

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“…Using optical procedures, fluorescence and near-infrared absorption spectroscopy or imaging are the dominant effects for determination of film thickness [4,13]. The fluorescence approach provides access to the local film thickness if any fluorescent material is available or added to the liquids, thus altering the composition of the liquid stream.…”

Section: Local Film Thicknessmentioning

confidence: 99%

“…Such 2D approaches as ultraviolet-visible (UV/VIS), fluorescence and near-infrared imaging provide local, molecule-sensitive and non-contact concentrations. Every 2D measurement point is a mean value over the local film thickness [4,15].…”

Section: Concentration Measurements On Trickle and Falling Filmsmentioning

confidence: 99%

“…This allows us to reduce the amount of assumptions needed and to verify those made. Therefore, this publication proposes to complement the previously established methods, in which flow resistances influence the films or scanning operations obtaining summary information via near-infrared absorptions or fluorescence detection [4,5]. Raman scanning from a large working distance has not yet been established in the world of process engineering.…”

Section: Introductionmentioning

confidence: 99%

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Liquid Mixing on Falling Films: Marker-Free, Molecule-Sensitive 3D Mapping Using Raman Imaging

Nachtmann

Feger

Wühler

et al. 2023

Sensors

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Following up on a proof of concept, this publication presents a new method for mixing mapping on falling liquid films. On falling liquid films, different surfaces, plain or structured, are common. Regarding mixing of different components, the surface has a significant effect on its capabilities and performance. The presented approach combines marker-free and molecule-sensitive measurements with cross-section mapping to emphasize the mixing capabilities of different surfaces. As an example of the mixing capabilities on falling films, the mixing of sodium sulfate with tap water is presented, followed by a comparison between a plain surface and a pillow plate. The method relies upon point-by-point Raman imaging with a custom-built high-working-distance, low-depth-of-focus probe. To compensate for the long-time measurements, the continuous plant is in its steady state, which means the local mixing state is constant, and the differences are based on the liquids’ position on the falling film, not on time. Starting with two separate streams, the mixing progresses by falling down the surface. In conclusion, Raman imaging is capable of monitoring mixing without any film disturbance and provides detailed information on liquid flow in falling films.

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“…Medina et al determined the local concentration and viscosity of glycerol/water mixtures in microchannels with near-infrared imaging using a near-infrared camera and LEDs in this range [69].…”

Section: Introductionmentioning

confidence: 99%

Film Thickness and Glycerol Concentration Mapping of Falling Films Based on Fluorescence and Near-Infrared Technique

2022

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Falling film evaporation processes involve high fluid velocities with continuous variations in local film thickness, fluid composition, and viscosity. This contribution presents a parallel and complementary film thickness and concentration mapping distribution in falling films using a non-invasive fluorescence and near-infrared imaging technique. The experiments were performed with a mixture of glycerol/water with a mass fraction from 0 to 0.65 gglycgtotal−1 and operating ranges similar to evaporation processes. The measurement system was designed by integrating two optical measurement methods for experimental image analysis. The film thickness was evaluated using a VIS camera and high-power LEDs at 470 nm. The local glycerol concentration gglycgtotal−1 was determined using a NIR camera and high-power LEDs at 1050, 1300, 1450 and 1550 nm. A multiwavelength analysis with all NIR wavelengths was implemented with a better correlation for falling films at low flow velocity. The results show an improvement in the analysis of falling films with high flow velocities up to almost 500 mm/s by using only the 1450 nm wavelength and the fluorescence measurement. Simultaneous imaging analysis of film thickness and concentration in falling films provides further insight into understanding mass and heat transport and thus supports the optimization of falling film evaporators.

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Visualization of Local Concentration and Viscosity Distribution during Glycerol-Water Mixing in a Y-Shape Minichannel: A Proof-of-Concept-Study

Cited by 5 publications

References 31 publications

Single‐Particle Tracking and Trajectory Analysis of Fluorescent Nanodiamonds in Cell‐Free Environment and Live Cells

Single‐Particle Tracking and Trajectory Analysis of Fluorescent Nanodiamonds in Cell‐Free Environment and Live Cells

Liquid Mixing on Falling Films: Marker-Free, Molecule-Sensitive 3D Mapping Using Raman Imaging

Film Thickness and Glycerol Concentration Mapping of Falling Films Based on Fluorescence and Near-Infrared Technique

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