Visualization of Prostate Cancer with 11C-Choline Positron Emission Tomography

Jong, Igle J. de; Pruim, Jan; Elsinga, Philippus; Vaalburg, W; Mensink, H. J. A.

doi:10.1016/s0302-2838(02)00129-x

Cited by 157 publications

(71 citation statements)

References 15 publications

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“…The tmr declined from 7.4 ± 0.6 (n = 11) before ebrt to 6.1 ± 0.4 (n = 11, nonsignificant) during week 8 of ebrt, to 5.6 ± 0.03 (n = 11, p < 0.05) at 2 months after ebrt, and to 4.4 ± 0.4 (n = 11, p < 0.001) at 12 months after ebrt. 16,17 . Uptake of [ 11 C]-choline correlates with increased levels of prostate-specific antigen (psa) in some studies, but that finding is not consistent in the literature 1 .…”

Section: Resultsmentioning

confidence: 99%

Analysis of Intraprostatic Therapeutic Effects in Prostate Cancer Patients Using [11C]-Choline pet/ct after External-Beam Radiation Therapy

et al. 2013

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ConclusionsOur study demonstrated that intraprostatic [ 11 C]-choline uptake in the 11 analyzed prostate cancer patients significantly declined during and after ebrt. The pet parameters SUV max and tmr also declined significantly. These effects can be detected during radiation therapy and up to 1 year after therapy. The prognostic value of these early and statistically significant changes in intraprostatic

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Section: Resultsmentioning

confidence: 99%

Analysis of Intraprostatic Therapeutic Effects in Prostate Cancer Patients Using [11C]-Choline pet/ct after External-Beam Radiation Therapy

et al. 2013

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“…Promising results for staging patients with prostate carcinoma have been reported with labelled choline compounds. Some studies have used carbon-11 labelled choline [4,5,6], whose clinical usefulness is limited by the short half-life of 11 C. This problem is overcome by 18 F-labelled choline (FCH), which has recently been introduced and has also shown promising results in the evaluation of patients with prostate cancer [7,8,9,10]. For every tumour imaging compound it is important to know the accumulation characteristics in non-tumorous lesions, of which inflammatory/infectious foci are among the most important.…”

Section: Introductionmentioning

confidence: 99%

18 F-choline in experimental soft tissue infection assessed with autoradiography and high-resolution PET

Wyss

Weber

Honer

et al. 2004

European Journal of Nuclear Medicine and Molecular Imaging

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Abstract. For each oncological tracer it is important to know the uptake in non-tumorous lesions. The purpose of this study was to measure the accumulation of fluorine-18 choline (FCH), a promising agent for the evaluation of certain tumour types, in infectious tissue. Unilateral thigh muscle abscesses were induced in five rats by intramuscular injection of 0.1 ml of a bacterial suspension (Staphylococcus aureus, 1.2×10 9 CFU/ml). In all animals, FCH accumulation was measured with highresolution positron emission tomography (PET) on day 6. Autoradiography of the abscess and ipsilateral healthy muscle was performed on day 7 (three animals) and day 11 (two animals) and correlated with histology. In addition, 18 F-fluorodeoxyglucose (FDG) PET was performed on day 5. Increased FCH uptake was noted in specific layers of the abscess wall which contained an infiltrate of mainly granulocytes on day 7 and mainly macrophages on day 11. The autoradiographic standardised uptake values in the most active part of the abscess wall were 2.99 on day 7 (n=3) and 4.05 on day 11 (n=2). In healthy muscle the corresponding values were 0.99 and 0.64. The abscesses were clearly visualised on the FCH and FDG PET images. In conclusion, this study demonstrated avid FCH accumulation in inflammatory tissue, which limits the specificity of FCH for tumour detection. Future studies are now needed to determine the degree of this limitation in human cancer patients.

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“…Por el contrario, el desarrollo de nuevos radiofármacos, como el 11 C o 18 F-colina, o la 11 C-acetato, parecen prometedores en la detección de células malignas del cáncer de próstata [18][19][20][21] .…”

Section: Introductionunclassified

“…Los trabajos publicados con 11 C-colina han confirmado su corta vida media (20 min) y una captación preferente por el cáncer de próstata, los ganglios linfáticos afectados y las metástasis [18][19][20][22][23][24][25] . La colina marcada con 11 C o 18 F tiene una alta sensibilidad para localizar el tumor primario en el lóbulo prostático, e incluso en la biopsia sextante 24,26 ; sin embargo, como desventaja, se ha evidenciado una gran afinidad de ambos radiofármacos por la hiperplasia benigna 27 .…”

Section: Introductionunclassified