Visually induced initiation of Drosophila innate courtship-like following pursuit is mediated by central excitatory state

Kohatsu, Soh; Yamamoto, Daisuke

doi:10.1038/ncomms7457

Cited by 128 publications

(143 citation statements)

References 29 publications

Supporting

Mentioning

137

Contrasting

Order By: Relevance

“…Stimulation of a subset of P1 neurons (labeled by the Gal4 line R71G01, here referred to as P1-B in reference to the Baker lab where it was first characterized) has been shown to drive courtship behaviors toward moving, fly-sized inanimate objects (Kohatsu and Yamamoto, 2015;Pan et al, 2012). In our hands, activation of P1-B neurons drives robust courtship behavior toward even stationary rubber band pieces-if they are painted black ( Figure 5A; Movie S2).…”

Section: Figure 2 Mating Drive Reflects But Is Not Acutely Instructmentioning

confidence: 85%

Dopaminergic Circuitry Underlying Mating Drive

Zhang

Rogulja

Crickmore

2016

Neuron

138

208

View full text Add to dashboard Cite

We develop a new system for studying how innate drives are tuned to reflect current physiological needs and capacities, and how they affect sensory-motor processing. We demonstrate the existence of male mating drive in Drosophila, which is transiently and cumulatively reduced as reproductive capacity is depleted by copulations. Dopaminergic activity in the anterior of the superior medial protocerebrum (SMPa) is also transiently and cumulatively reduced in response to matings and serves as a functional neuronal correlate of mating drive. The dopamine signal is transmitted through the D1-like DopR2 receptor to P1 neurons, which also integrate sensory information relevant to the perception of females, and which project to courtship motor centers that initiate and maintain courtship behavior. Mating drive therefore converges with sensory information from the female at the point of transition to motor output, controlling the propensity of a sensory percept to trigger goal-directed behavior.

show abstract

Section: Figure 2 Mating Drive Reflects But Is Not Acutely Instructmentioning

confidence: 85%

Dopaminergic Circuitry Underlying Mating Drive

Zhang

Rogulja

Crickmore

2016

Neuron

138

208

View full text Add to dashboard Cite

show abstract

“…In mammals, brain circuits are thought to compute adaptive neural functions that underlie action-selection (or ‘decision-making’), while spinal circuits communicate bidirectionally with the brain, such that descending pathways activate motor programs and ascending pathways report on their execution (Arber, 2012). This organizing principle also exists in the fly: male-specific ‘decision-making’ neurons in the brain (e.g., P1; pC2I; dopaminergic neurons) integrate multimodal sensory cues to initiate and modulate courtship and copulatory behaviors (Kimura et al, 2008; Yu et al, 2010; Kohatsu et al, 2011; von Philipsborn et al, 2011; Pan et al, 2012; Inagaki et al, 2014; Kohatsu and Yamamoto, 2015; Zhang et al, 2016), while descending ‘command’ neurons (e.g., pIP10) relay information from the ‘decision-making’ neurons, to activate ‘pattern generator’-like motor circuits in the VNC (Clyne and Miesenbock, 2008; von Philipsborn et al, 2011; Inagaki et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

“…Indeed, optogenetic activation of dsx -expressing pC2l cluster of neurons in the male brain has been shown to induce attempts to copulate (Kohatsu and Yamamoto, 2015). However, activating dsx neurons in solitary headless males elicits abdominal curling (Pan et al, 2011) and decapitating males in copulo has little effect on the duration of copulation (Tayler et al, 2012; Crickmore and Vosshall, 2013), suggesting the Abg can direct many copulatory behaviors independent of any input from the brain.…”

Section: Introductionmentioning

confidence: 99%

Neural circuitry coordinating male copulation

Pavlou

Lin

Neville

et al. 2016

eLife

View full text Add to dashboard Cite

Copulation is the goal of the courtship process, crucial to reproductive success and evolutionary fitness. Identifying the circuitry underlying copulation is a necessary step towards understanding universal principles of circuit operation, and how circuit elements are recruited into the production of ordered action sequences. Here, we identify key sex-specific neurons that mediate copulation in Drosophila, and define a sexually dimorphic motor circuit in the male abdominal ganglion that mediates the action sequence of initiating and terminating copulation. This sexually dimorphic circuit composed of three neuronal classes – motor neurons, interneurons and mechanosensory neurons – controls the mechanics of copulation. By correlating the connectivity, function and activity of these neurons we have determined the logic for how this circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit-level dissection of active sensing and modulation of copulatory behavior.DOI: http://dx.doi.org/10.7554/eLife.20713.001

show abstract

“…These neurons receive information from courtship-relevant sensory pathways (e.g., those that carry pheromonal (Clowney et al, 2015; Kohatsu et al, 2010), visual (Kohatsu and Yamamoto, 2015) and auditory (Zhou et al, 2015) cues) and synapse onto motor “command neurons” (e.g. pIP10 (von Philipsborn et al, 2011)).…”

Section: Discussionmentioning

confidence: 99%

Sensorimotor Transformations Underlying Variability in Song Intensity during Drosophila Courtship

Coen

Xie

Clemens

et al. 2016

Neuron

135

View full text Add to dashboard Cite

Summary Diverse animal species, from insects to humans, utilize acoustic signals for communication. Studies of the neural basis for song or speech production have focused almost exclusively on the generation of spectral and temporal patterns, but animals can also adjust acoustic signal intensity when communicating. For example, humans naturally regulate the loudness of speech in accord with a visual estimate of receiver distance. The underlying mechanisms for this ability remain uncharacterized in any system. Here, we show that Drosophila males modulate courtship song amplitude with female distance, and we investigate each stage of the sensorimotor transformation underlying this behavior, from the detection of particular visual stimulus features and the timescales of sensory processing, to the modulation of neural and muscle activity that generates song. Our results demonstrate an unanticipated level of control in insect acoustic communication, and uncover novel computations and mechanisms underlying the regulation of acoustic signal intensity during communication.

show abstract

Visually induced initiation of Drosophila innate courtship-like following pursuit is mediated by central excitatory state

Cited by 128 publications

References 29 publications

Dopaminergic Circuitry Underlying Mating Drive

Dopaminergic Circuitry Underlying Mating Drive

Neural circuitry coordinating male copulation

Sensorimotor Transformations Underlying Variability in Song Intensity during Drosophila Courtship

Contact Info

Product

Resources

About