This paperpresents a three-axis vision motion sensor and its applications to visual servo control. The vision sensor is integrated with a three-axis piezo stage to form a visual servo control system that achieves nanometer resolution in all three xy-z motion axes. Motion measurement is achieved using a single interferometer-equipped optical microscope. A real-time imageprocessing algorithm that processes interference fringe patterns and that achieves nanometer out-of-plane resolution is presented. Furthermore, a feedback-control scheme is introduced to control the sensor plane using an Objective-Z-Positioner to enable automatic tracking of moving objects. It expands the out-of-plane measurement range of the vision sensor beyond its inherent depth of field of several micrometers to 100 µm and beyond. An integrated visual servo system is implemented and experimental results are shown.Index Terms-Fringe pattern, interferometry, laterally sampled white light interferometry (L-SWLI), motion measurement, optical microscope, visual servo control, white light interferometry (WLI).