Vitamin A deficiency indicating as low expression of LRAT may be a novel biomarker of primary hypertension

Liang, Xiaohua; Chen, Min; Wang, Dong; Wen, Jing; Chen, Jie

doi:10.1080/10641963.2020.1833023

Cited by 12 publications

(9 citation statements)

References 46 publications

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“…In our previous study, we found that low LRAT expression was relevant to both vitamin A deficiency and high BP in children and that LRAT may affect BP levels by decreasing angiotensin-converting enzyme (ACE) levels. 42 However, no significant relationship was found between the serum vitamin A level and BP, 43 which was consistent with the results of a randomized clinical trial performed by Agustin Llopis-González and colleagues. 44 In a previous study, LRAT was found to be a key molecule in retinol metabolism by which holo-RBP activated the STRA6/JAK/STAT signal cascade, 45 and this signal cascade has been associated with BP control.…”

Section: Discussionsupporting

confidence: 75%

“…In this study, the relative LRAT expression level was identified as an independent risk factor for the occurrence of hypertension, which was consistent with the results of our previous study. 42 However, there was little evidence of the relationship between serum vitamin A levels and hypertension. In our previous study, we found that low LRAT expression was relevant to both vitamin A deficiency and high BP in children and that LRAT may affect BP levels by decreasing angiotensin-converting enzyme (ACE) levels.…”

Section: Discussionmentioning

confidence: 99%

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Combining multiaspect factors to predict the risk of childhood hypertension incidence

Tong

Zhao

et al. 2022

J of Clinical Hypertension

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Childhood hypertension has become a global public health issue due to its increasing prevalence and association with cerebral‐cardiovascular disease in adults. In this study, we developed a predictive model for childhood hypertension based on environmental and genetic factors to identify at‐risk individuals. Eighty children diagnosed with childhood hypertension and 84 children in the control group matched by sex and age from an established cohort were included in a nested case–control study. We constructed a multiple logistic regression model to analyze the factors associated with hypertension and applied the 10‐fold cross‐validation method to verify the prediction stability of the model. Childhood hypertension was found positively correlated with triglyceride level ≥150 mg/dL; low‐density lipoprotein cholesterol level ≥110 mg/dL; body mass index Z score; waist‐to‐height ratio Z score; and red blood cell count (all P < .01) and negatively correlated with the relative expression level of retinol acyltransferase; relative expression level of vitamin D receptor; and dietary intake of fiber, vitamin C and copper (all P < .05) in this study. BMI Z score, triglyceride ≥150 mg/dL, RBC count, VDR/β‐actin and LRAT/β‐actin ratios were used to construct the predictive model. The area under the receiver operating characteristic curve was 94.45% (95% CI = 89.35%∼98.65%, P < .001). The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were all above 80% in both the training and validation sets. In conclusion, this model can predict the risk of childhood hypertension and could provide a theoretical basis for early prevention and intervention to improve the cardiovascular health of children.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Combining multiaspect factors to predict the risk of childhood hypertension incidence

Tong

Zhao

et al. 2022

J of Clinical Hypertension

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“…The protein encoded by SMPD4 was a sphingomyelinase involved in sphingolipid metabolism pathway, and mounting evidence pointed toward that a derangement of this pathway might trigger the precursor clinical conditions of hypertension and hypertension itself [ 54 ]. It was found that LRAT may be a critical biomarker of vitamin A deficiency in target organs and may regulate blood pressure through affecting renin angiotensin system biomarkers [ 55 ]. TNK2 gene was involved in the oxidative damage response pathway, and it was demonstrated that inflammation and oxidative stress significantly contributed to the vascular dysfunction and renal damage associated with hypertension [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure

Wang

Yao

et al. 2023

Clin Epigenet

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Background Hypertension is a crucial risk factor for developing cardiovascular disease and reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially related to systolic blood pressure (SBP) and diastolic blood pressure (DBP) by conducting epigenome-wide association studies in 60 and 59 Chinese monozygotic twin pairs, respectively. Methods Genome-wide DNA methylation profiling in whole blood of twins was performed using Reduced Representation Bisulfite Sequencing, yielding 551,447 raw CpGs. Association between DNAm of single CpG and blood pressure was tested by applying generalized estimation equation. Differentially methylated regions (DMRs) were identified by comb-P approach. Inference about Causation through Examination of Familial Confounding was utilized to perform the causal inference. Ontology enrichment analysis was performed using Genomic Regions Enrichment of Annotations Tool. Candidate CpGs were quantified using Sequenom MassARRAY platform in a community population. Weighted gene co-expression network analysis (WGCNA) was conducted using gene expression data. Results The median age of twins was 52 years (95% range 40, 66). For SBP, 31 top CpGs (p < 1 × 10–4) and 8 DMRs were identified, with several DMRs within NFATC1, CADM2, IRX1, COL5A1, and LRAT. For DBP, 43 top CpGs (p < 1 × 10–4) and 12 DMRs were identified, with several DMRs within WNT3A, CNOT10, and DAB2IP. Important pathways, such as Notch signaling pathway, p53 pathway by glucose deprivation, and Wnt signaling pathway, were significantly enriched for SBP and DBP. Causal inference analysis suggested that DNAm at top CpGs within NDE1, MYH11, SRRM1P2, and SMPD4 influenced SBP, while SBP influenced DNAm at CpGs within TNK2. DNAm at top CpGs within WNT3A influenced DBP, while DBP influenced DNAm at CpGs within GNA14. Three CpGs mapped to WNT3A and one CpG mapped to COL5A1 were validated in a community population, with a hypermethylated and hypomethylated direction in hypertension cases, respectively. Gene expression analysis by WGCNA further identified some common genes and enrichment terms. Conclusion We detect many DNAm variants that may be associated with blood pressure in whole blood, particularly the loci within WNT3A and COL5A1. Our findings provide new clues to the epigenetic modification underlying hypertension pathogenesis.

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“…Venous blood (3 mL) was drawn in the morning after at least 12 h of fasting from subjects who provided informed consent[ 24 ]. FBG, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), TGs, fasting insulin (FI), and glycosylated haemoglobin were measured within 2 h after blood draw; details are provided in other publications[ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Relationship between quality of life and adolescent glycolipid metabolism disorder: A cohort study

Liang

Ren

Liang

et al. 2022

WJD

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BACKGROUND The prevalence of glucolipid metabolic disorders (GLMDs) in children and adolescents has a recognized association with cardiovascular diseases and type 2 diabetes mellitus in adulthood. Therefore, it is important to enhance our under-standing of the risk factors for GLMD in childhood and adolescence. AIM To explore the relationship between quality of life (QoL) and adolescent GLMD. METHODS This study included 1956 samples in 2019 from a cohort study established in 2014. The QoL scale and glycolipid indexes were collected during follow-up; other covariates of perinatal factors, physical measures, and socioeconomic indicators were collected and adjusted. A generalized linear regression model and logistic regression model were used to analyse the correlation between QoL and GLMD. RESULTS Higher scores of QoL activity opportunity, learning ability and attitude, attitude towards doing homework, and living convenience domains correlated negatively with insulin and homeostasis model assessment insulin resistance (IR) levels. Psychosocial factors, QoL satisfaction factors, and total QoL scores had significant protective effects on insulin and IR levels. Activity opportunity, learning ability and attitude, attitude towards doing homework domains of QoL, psychosocial factor, and total score of QoL correlated positively with high density lipoprotein. In addition, the attitude towards doing homework domain was a protective factor for dyslipidaemia, IR > 3, and increased fasting blood glucose; four factors, QoL and total QoL score correlated significantly negatively with IR > 3. In subgroup analyses of sex, more domains of QoL correlated with insulin and triglyceride levels, dyslipidaemia, and IR > 3 in females. Poor QoL was associated with an increased prevalence of GLMD, and the effect was more pronounced in males than in females. Measures to improve the QoL of adolescents are essential to reduce rates of GLMD. CONCLUSION Our study revealed that QoL scores mainly correlate negatively with the prevalence of GLMD in adolescents of the healthy population. The independent relationship between QoL and GLMD can be illustrated by adjusting for multiple covariates that may be associated with glycaemic index. In addition, among females, more QoL domains are associated with glycaemic index.

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Vitamin A deficiency indicating as low expression of LRAT may be a novel biomarker of primary hypertension

Cited by 12 publications

References 46 publications

Combining multiaspect factors to predict the risk of childhood hypertension incidence

Combining multiaspect factors to predict the risk of childhood hypertension incidence

Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure

Relationship between quality of life and adolescent glycolipid metabolism disorder: A cohort study

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