Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis

Reddy, Mooli Raja Gopal; Venkata, Surekha Mullapudi; Putcha, Uday Kumar; Jeyakumar, Shanmugam M.

doi:10.1016/j.yexcr.2018.01.040

Cited by 18 publications

(8 citation statements)

References 33 publications

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“…The feeding of a VAD diet reduces the retinol content, and increases the MUFAs in the kidney probably due to the regulation of SCD1 activity[ 71 ]. In the pancreas of rats fed a VAD diet for 16 wk, the oleic acid content is reduced, which is associated with the reduction of SCD1 protein level[ 72 ].…”

Section: Effects Of Vitamin a Status And Ra On Desaturasesmentioning

confidence: 99%

Roles of vitamin A in the regulation of fatty acid synthesis

Fang¹,

Xu²,

Wang³

et al. 2021

WJCC

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Dietary macronutrients and micronutrients play important roles in human health. On the other hand, the excessive energy derived from food is stored in the form of triacylglycerol. A variety of dietary and hormonal factors affect this process through the regulation of the activities and expression levels of those key player enzymes involved in fatty acid biosynthesis such as acetyl-CoA carboxylase, fatty acid synthase, fatty acid elongases, and desaturases. As a micronutrient, vitamin A is essential for the health of humans. Recently, vitamin A has been shown to play a role in the regulation of glucose and lipid metabolism. This review summarizes recent research progresses about the roles of vitamin A in fatty acid synthesis. It focuses on the effects of vitamin A on the activities and expression levels of mRNA and proteins of key enzymes for fatty acid synthesis in vitro and in vivo . It appears that vitamin A status and its signaling pathway regulate the expression levels of enzymes involved in fatty acid synthesis. Future research directions are also discussed.

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Section: Effects Of Vitamin a Status And Ra On Desaturasesmentioning

confidence: 99%

Roles of vitamin A in the regulation of fatty acid synthesis

Fang¹,

Xu²,

Wang³

et al. 2021

WJCC

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“…В последние годы накопились данные, свидетельствующие о том, что гиповитаминозы часто сопровождают болезни ПЖ [38][39][40][41]. В экспериментальном исследовании витамин-А-дефицитная диета вызывала внутриостровковую дилатацию сосудов ПЖ и уменьшение сывороточных уровней инсулина, глюкагона и C-пептида; дефицит витамина А изменял структуру и функции ПЖ, уменьшая клетки островков, возможно, вызывая клеточный стресс-опосредованный апоптоз и уменьшая стеароил-Ко-А-десатураза 1-опосредованный синтез олеиновой кислоты [38]. В нашем исследовании дефицитное потребление витаминов А и Е практически в 2 раза чаще обнаружено у больных 1-й группы с экскреторной недостаточностью.…”

Section: Discussionunclassified

Risk factors for pancreatitis and pancreatic cancer

Григорьева

Николаевна²,

Efimova

et al. 2021

Terapevticheskii arkhiv

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Aim. To identify and compare the frequency of alcohol consumption, tobacco smoking, levels of main macronutrients, vitamins and mineral elements consumption in patients with acute (AP) and chronic pancreatitis (CP) and pancreatic cancer (PC). Materials and methods. At the observational clinical cross-sectional uncontrolled case-study 65 patients with AP or CP (group 1) and 45 patients with PC (group 2) were examined. A survey of patients was carried out: questionnaire on tobacco smoking, a frequency questionnaire on alcohol consumption, a questionnaire for assessing the frequency of food consumption. Results. The frequency of smoking (33.8, 20.0%; p0.05), alcohol consumption 1 times/week during the last year (21.5, 15.6%; p0.05) did not differ significantly between the two groups. The highest consumption rates of total, vegetable, animal protein, total carbohydrates, refined sugar, animal fat, cholesterol, MUFA, dietary fiber, vitamins (-carotene, vitamin B1, B2, C, PP), mineral elements (iron, potassium, calcium, magnesium, sodium, phosphorus) and the daily energy content of the diet were determined in PC than in the AP and CP group. Among patients of group 1, deficient intake of fat-soluble vitamin A (93.3, 54.8%; p=0.009) and vitamin E (80.0, 48.4%; p=0.041) was more common in the subgroup of patients with excretory pancreatic insufficiency than without it, and the chance of having hypercholesterolemia was associated with a deficient intake of vitamin E [Ex(B)=3.3, 95% CI 1.59.3; p=0.027]. Conclusion. There were no differences in the frequency of smoking and alcohol consumption between patients with AP and CP and PC. The highest indices of the main macronutrients, daily energy content of the diet, micronutrients (except for vitamins A, E) were found in PC than in the group of patients with AP and CP. Among patients with AP and CP with excretory pancreatic insufficiency, a lower intake of fat-soluble vitamins was noted and associations of hypercholesterolemia with deficient intake of vitamin E were obtained.

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“…An animal study published in 2018 by Raja et al [17] resulted in plasma insulin, glucagon and C peptide levels decrease with additional perturbed overall cellular metabolism after feeding rodents with vitamin A deficient diet. Investigations further demonstrated an altered structure and function of pancreas evidenced by diminished islet cells possibly due to induced cellular stress-mediated apoptosis and reducing steatoryl-CoA desaturase 1-mediated oleic acid (SCD1) synthesis.…”

Section: Vitamin a Levels And The Control Of Hyperglycemiamentioning

confidence: 99%

“…After vitamin A treatment in diabetes-induced female albino mice, GLUT4 expression levels were assayed by sandwich ELISA in adipocytes and skeletal muscles. A slight increase in GLUT4 expression at the membrane was observed which may in turn cause possible increase in glucose uptake in skeletal muscles and adipocytes (Table 1) [13,17,19,20]. Comucci et al [20] Cross Sectional Significant increase in Insulin resistance with higher level of RBP4 Low glucose uptake by skeletal muscle and high glucose liver production in mice, and consequently increase in insulin resistance…”

Section: Vitamin a Levels And The Control Of Hyperglycemiamentioning

confidence: 99%

The Role of Vitamin a in the Control of Hyperglycemia in Type 2 Diabetes Mellitus: A Narrative Review

Daniega

2022

AJHS

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Objective: Diabetes Mellitus, specifically Type 2 Diabetes Mellitus which accounts for almost 90% of all diabetes, has emerged as one of the biggest pandemics of modern times. Investigations are underway, with different areas of focus due to the disease' heterogeneity. This review paper will go through some research which has been done to illustrate the role of Vitamin A in the control of hyperglycemia in T2DM.Methods: An online Literature search was done using electronic databases from MedLine, PubMed, Google Scholar and ResearchGate published mostly in the years 2014-2019.Result: Retinol binding protein levels especially of RBP4 was found to be positively associated with insulin resistance which was elucidated by the mechanism of low glucose uptake in skeletal muscles and enhanced gluconeogenesis in the liver of mice. Furthermore, the antioxidant property of Vitamin A was also given focus due to the fact that hyperglycemia in T2DM result to oxidative stress because of production of reactive oxygen species (ROS). Another novel mechanism of Vitamin A's ability to control hyperglycemia in T2DM as demonstrated by retinol supplementation in animal studies' is the suppression of retinoid-x-receptor resulting to decreased adipogenesis, with consequent improved insulin sensitivity. The other mechanisms include the following: a) low Vitamin A level demonstrated diminished islet cells due to induced cellular stressmediated apoptosis and reducing steatoryl-CoA desaturase 1-mediated oleic acid (SCD1) synthesis. b)vitamin A showed slight increase in GLUT4 expression causing increase in glucose uptake in skeletal muscles and adipocytes. Conclusion:The different biochemical bases of how Vitamin A level affects insulin sensitivity/resistance through its antioxidant property, expression of GLUT4 transport protein for enhanced muscle and adipose glucose uptake, and decreased adipogenesis/lipogenesis provide strong evidence on its important role in the control of hyperglycemic state in T2DM.

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Vitamin A deficiency induces endoplasmic reticulum stress and apoptosis in pancreatic islet cells: Implications of stearoyl-CoA desaturase 1-mediated oleic acid synthesis

Cited by 18 publications

References 33 publications

Roles of vitamin A in the regulation of fatty acid synthesis

Roles of vitamin A in the regulation of fatty acid synthesis

Risk factors for pancreatitis and pancreatic cancer

The Role of Vitamin a in the Control of Hyperglycemia in Type 2 Diabetes Mellitus: A Narrative Review

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