Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin

Jenning, Volkhard; Gysler, Anja; Schäfer‐Korting, Monika; Gohla, Sven

doi:10.1016/s0939-6411(99)00075-2

Cited by 456 publications

(208 citation statements)

References 17 publications

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“…Also, this higher cidofovir concentration in the first skin layers could be due to an occlusive effect, since microparticles produced a film on the skin surface, which reduces the transepidermal water loss and favours drug penetration into the skin. The same feature has been observed using acyclovir-loaded microparticles (Gª de Jalón et al, 2001b) and solid lipid nanoparticles (Jenning et al, 2000b).…”

Section: Skin Penetration and Distribution Of Cidofovir-loaded Micropsupporting

confidence: 81%

Optimization of topical cidofovir penetration using microparticles

Santoyo

Jalón

Ygartua

et al. 2002

International Journal of Pharmaceutics

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Cidofovir is a new class of antiviral agent with potent in vitro and in vivo activity against a broad spectrum of herpes viruses. The aim of this work was to obtain a prolonged therapeutic effect of cidofovir in the basal epidermis after its topical application. For this purpose, PLGA microparticles were prepared by solvent evaporation and spray-drying methods. Microparticles prepared by spray-drying showed a encapsulation efficiency of 80%.Conversely, for all the microspheres prepared by the W/O/W solvent evaporation method the encapsulation efficiency was low. Also, microparticles prepared by spray-drying showed a higher burst release. Skin penetration and distribution experiments were carried out with cidofovir-loaded microparticles prepared by spray-drying, since these carriers presented the best characteristics in terms of size and encapsulation efficiency. A cidofovir solution in 0.2% PVA served for comparison. Penetration experiments were carried out in Franz type diffusion cells with an available diffusion area of 1.76 cm 2 , using porcine skin. The results obtainedshowed that the amount of cidofovir penetrated, over a 24 h time period, was higher with the drug solution than with microparticles. Cidofovir distribution in porcine skin, after topical application of microparticles and drug solution for 24 h, was determined by horizontal slicing of the skin. The profiles obtained for the two formulations showed that the quantity of cidofovir retained in the skin decreased with the depth. Besides the amount of cidofovir found in the basal epidermis (120-150 μm) was much higher with microparticles than with the control solution. These data showed that cidofovir-loaded microparticles could improve cidofovir topical therapy since these vehicles increased drug retention in the basal epidermis and decreased its penetration through the skin.

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Section: Skin Penetration and Distribution Of Cidofovir-loaded Micropsupporting

confidence: 81%

Optimization of topical cidofovir penetration using microparticles

Santoyo

Jalón

Ygartua

et al. 2002

International Journal of Pharmaceutics

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“…The results had showed that the transepidermal water loss and the influence of drug free SLN on retinyl palmitate uptake exclude pronounced occlusive effects. Therefore enhanced retinyl palmitate uptake should derive from specific SLN effects and is not due to non-specific occlusive properties [110] .…”

Section: Recent Advances Of Bioenhancersmentioning

confidence: 99%

Bioavailability enhancers of herbal origin: An overview

Kesarwani

Gupta

2013

Asian Pacific Journal of Tropical Biomedicine

397

197

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“…Due to occlusion, water evaporation from the skin to the atmosphere is decreased and water is thus retained within the skin. The stratum corneum swells, which leads to a drug penetration enhancing effect (Jenning et al, 2000;Wissing et al, 2001;Loo et al, 2013).…”

Section: In Vitro Studymentioning

confidence: 99%

Design of solid lipid nanoparticles for caffeine topical administration

et al. 2014

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Caffeine is an interesting compound showing anticancer and protective effects upon topical administration, although its penetration through the skin is compromised by its hydrophilicity. Materials and methods: SLN-CAF were formulated by using a modification of the quasi-emulsion solvent diffusion technique (QESD) and characterized by PCS and DSC analyses. In vitro percutaneous absorption studies were effected using excised human skin membranes (i.e. Stratum Corneum Epidermis or SCE).Results: SLN-CAF were in a nanometric range (182.6 ± 8.4 nm) and showed an interesting payload value (75% ± 1.1). DSC studies suggest the presence of a well-defined system and the successful drug incorporation. Furthermore, SLN-CAF generated a significantly faster permeation than a control formulation over 24 h of monitoring. Discussion and conclusions: SLN-CAF were characterized by valid dimensions and a good encapsulation efficiency, although the active to incorporate showed a hydrophilic character. This result confirms the suitability of the formulation strategy employed in the present work. Furthermore, the in vitro evidence outline the key role of lipid nanoparticles in enhancing caffeine permeation through the skin.

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Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin

Cited by 456 publications

References 17 publications

Optimization of topical cidofovir penetration using microparticles

Optimization of topical cidofovir penetration using microparticles

Bioavailability enhancers of herbal origin: An overview

Design of solid lipid nanoparticles for caffeine topical administration

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